DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and GNP1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_010796.1	Gene:	GNP1 / 852121	SGDID:	S000002916	Length:	663	Species:	Saccharomyces cerevisiae

Alignment Length:	580	Identity:	115/580 - (19%)
Similarity:	213/580 - (36%)	Gaps:	142/580 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SGICTKMNRTKSVPT--DVMETP---------LNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKE 67
            |.:..::||..|..|  .:.::|         |.:.:......::.:|..:|.|:.|....|...
Yeast   113 SQLDNELNRKSSYITVDGIKQSPQEQEQKQENLKKSIKPRHTVMMSLGTGIGTGLLVGNSKVLNN 177

  Fly    68 MAGP-GIILSFILAG---FISMLA----ALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNI 124
             ||| |:|:.:.:.|   :..:.|    |:.|::.      .|....|....:.....|.:.|..
Yeast   178 -AGPGGLIIGYAIMGSCVYCIIQACGELAVIYSDL------IGGFNTYPLFLVDPALGFSVAWLF 235

  Fly   125 LLE-------HMLGAASVARAWSGYVDSMLGGWIGNTTLELTGGIHEPGLAQYPDVLA----FLV 178
            .|:       .::.|:...:.|:..|:                          |||..    .|:
Yeast   236 CLQWLCVCPLELVTASMTIKYWTTSVN--------------------------PDVFVVIFYVLI 274

  Fly   179 CIVYAAALAGGVKATAVFN--SLLTLVNIAVMVLVISVGFWYADG----KNWSE--AEGGFLP-Y 234
            .::......|..:|...||  .:|.:|...::.::|..|....||    |.|.:  |..|..| .
Yeast   275 VVINVFGAKGYAEADFFFNCCKILMIVGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQ 339

  Fly   235 GVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTL---MI 296
            ...||:|...|..:||...:.:|.:..|..||..:||.|....::.:...::   |:|||   ::
Yeast   340 RFKGVVATFVTAAFAFGMSEQLAMTASEQSNPRKAIPSAAKKMIYRILFVFL---ASLTLVGFLV 401

  Fly   297 PISE---INPAASLPEAFGQLNLSWAKYLISIGA--------------LCGMTTTLLGSLFALPR 344
            |.:.   :..|.|..:|        :.|:|::.:              |..:.:...|:.:...|
Yeast   402 PYTSDQLLGAAGSATKA--------SPYVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSR 458

  Fly   345 CMYAMASDGLLFSCFGKINPTTQVPLLNLVVS---GVMSACLALVFDLAKLVEFMSI-GTLLAYT 405
            .:.::|..|....||..|:...: |...::||   ||::.|.:...:.......::| |....:|
Yeast   459 ILMSLAKQGNAPKCFDYIDREGR-PAAAMLVSALFGVIAFCASSKKEEDVFTWLLAISGLSQLFT 522

  Fly   406 IVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSEMIEEVLAGRLK 470
            .::..:..:|:|         |...|.|.      ...:|..:|.:........::..|||  |.
Yeast   523 WITICLSHIRFR---------RAMKVQGR------SLGEVGYKSQVGVWGSAYAVLMMVLA--LI 570

  Fly   471 AQF-RCLEPLLGRFEPGSVVSVAVMLFIFLSFAICVELKVSWTQLYT--GTW---WALII 524
            ||| ..:.|:.|    |..:|.......:|:..|       |..||.  ..|   |:|.|
Yeast   571 AQFWVAIAPIGG----GGKLSAQSFFENYLAMPI-------WIALYIFYKVWKKDWSLFI 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	110/560 (20%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
GNP1	NP_010796.1	2A0310	146..626	CDD:273334	108/547 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345716
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.800