DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and AGP3

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_116600.1	Gene:	AGP3 / 850489	SGDID:	S000001839	Length:	558	Species:	Saccharomyces cerevisiae

Alignment Length:	525	Identity:	114/525 - (21%)
Similarity:	193/525 - (36%)	Gaps:	121/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGP-GIILSFILAGFISMLAALCYAEFG 95
            :|.:.|.|....|:||.:|.::|.|..|..|. |....|| .::|.|.:.|.|:........|..
Yeast    46 QTGVKRALKNRHISLLALGGVIGPGCLVGAGN-ALNKGGPLALLLGFSIIGIIAFSVMESIGEMI 109

  Fly    96 TRVPKAG---------------SAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWS----- 140
            |..|..|               :...|.|:        |:.:.:|.......:|:.:.|.
Yeast   110 TLYPSGGGFTTLARRFHSDALPAVCGYAYV--------VVFFAVLANEYNTLSSILQFWGPQVPL 166

  Fly   141 -GYVDSMLGGWIGNTTLELTG----GIHE--------PGLAQYPDVLAFLVCIVYAAALAGGVKA 192
             ||:   |..|......:|.|    |..|        .||..|     ::..|||   ::|.::.
Yeast   167 YGYI---LIFWFAFEIFQLVGVGLFGETEYWLAWLKIVGLVAY-----YIFSIVY---ISGDIRN 220

  Fly   193 TAVFNSLLTLVNIAVMVLVISVGFWYADGKNWSEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIA 257
            ...|                  ||.|     |:..  |.|.:|..|:......|...:.|.:|:|
Yeast   221 RPAF------------------GFHY-----WNSP--GALSHGFKGIAIVFVFCSTFYSGTESVA 260

  Fly   258 TSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASL-----PEAFGQLNLS 317
            .:..|:|||..::|:|...:|:.:.|.||.::......:|..:.|.:||.     |.|.......
Yeast   261 LAATESKNPGKAVPLAVRQTLWRILVVYIGIAVFYGATVPFDDPNLSASTKVLKSPIAIAISRAG 325

  Fly   318 WA--KYLISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQ---VPLLNLVVSG 377
            ||  .:|::...|....:.:.|||:...|.:..:|.:||.    .||...|.   ||:..:.
Yeast   326 WAGGAHLVNAFILITCISAINGSLYIGSRTLTHLAHEGLA----PKILAWTDRRGVPIPAIT--- 383

  Fly   378 VMSACLALVFDLAKLVEFM--SIGTLLAYTIV---SASVIILRYRPMERIHTTIRVPAVAGSPDD 437
                    ||:...|:..|  |:|...||:.:   |...:.:.:..:...|..||...||
Yeast   384 --------VFNALGLISLMNVSVGAANAYSYIVNLSGVGVFIVWGVISYTHLRIRKAWVA----- 435

  Fly   438 DDDDDEDVASQSSMDTSSPTSEMIEEVLAGRLKAQFRCLEPLLGRFEPGSVVSVAVML--FIFLS 500
            .....|::..::.....:|...:...:....::. :....|    |:.|:.|...::|  .|.|.
Yeast   436 QGRSIEELPYEALFYPWTPVLSLAANIFLALIQG-WSYFVP----FDAGNFVDAYILLPVGILLY 495

  Fly   501 FAICV 505
            ..|||
Yeast   496 IGICV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	114/525 (22%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
AGP3	NP_116600.1	2A0310	50..517	CDD:273334	113/521 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
TreeFam	0	0.000	Not matched by this tool.
	7	6.900