Protein Alignment CG13248 and SLC7A4

DIOPT Version :10

• Sequence 1: NP_649219.1
• Gene: CG13248 / 40254
• FlyBaseID: FBgn0036984
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_004164.2
• Gene: SLC7A4 / 6545
• HGNCID: 11062
• Length: 635
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 273/637 - (42%)
• Similarity: 387/637 - (60%)
• Gaps: 50/637 - (7%)

  Fly    13 LSGICTKMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSF 77
            |:.:|.|:||.|.:....|||.|.|||:|.|:.|||:|.|||:|:|||||.||||:|||.::|||
Human    11 LARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSF 75

  Fly    78 ILAGFISMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGY 142
            .:|...|:||||||||||.|||:.||||::||:||||.|||:||||:|||:::|.|:||||||||
Human    76 GVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGY 140

  Fly   143 VDSMLGGWIGNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAV 207
            :|||....|.|.|....|....|.|..|||.||..:.::.:|.::.|.:.::..|...:.:::.|
Human   141 LDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLV 205

  Fly   208 MVLVISVGFWYADGKNWSEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIPV 272
            ::.::.:||..|...|||..||||.|:|..||:||.|:|||||||||.||.|.|||:||..|:|:
Human   206 ILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPL 270

  Fly   273 ATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISIGALCGMTTTLLG 337
            |..|||.:....|||||..||||:|...::|.::|.:||.|....||.::::.|::|.|.|.||.
Human   271 AIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLS 335

  Fly   338 SLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVEFMSIGTLL 402
            .||:|||.:||||:|||.|..|..::|.||||:...:..|:::|.|||:.||..||:|:|:||||
Human   336 LLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLL 400

  Fly   403 AYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSEMIEEVLA- 466
            |||.|:.|:|:||::              ..||.................:.|...:::..|.|
Human   401 AYTFVATSIIVLRFQ--------------KSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHAS 451

  Fly   467 ----GRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAI---CVELKVSWTQLYTGTWWALII 524
                |.||...|.....|..:.||:||:.|  |.:.|:.||   || |....:.|:...|
Human   452 VPEPGELKPALRPYLGFLDGYSPGAVVTWA--LGVMLASAITIGCV-LVFGNSTLHLPHW----- 508

  Fly   525 YGFIIFAAGTCV------AVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAVTWVRFF 583
             |:|:....|.|      .|:..|.|..|..:|::|:||.:|||.|..||.||:.|..:|||||.
Human   509 -GYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFS 572

  Fly   584 VWVCIGMVVYFLYGIRNSKEGE-----VCSSYSILMTTSEAGKVPWGSFKAT 630
            :|:.:|:.|||.||||:|||.:     :.|::.::.        |.||.:.|
Human   573 IWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVF--------PRGSLEET 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	259/584 (44%)
SLC7A4	NP_004164.2	2A0303	26..592	CDD:273330	260/588 (44%)