DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and SLC7A1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_016876202.1	Gene:	SLC7A1 / 6541	HGNCID:	11057	Length:	643	Species:	Homo sapiens

Alignment Length:	576	Identity:	226/576 - (39%)
Similarity:	338/576 - (58%)	Gaps:	63/576 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILSGICTKMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILS 76
            :|..|..:|.|.|.|.....||.|:|||||||:..||:|..:|||:|||.|.||:|.|||.|::|
Human     5 VLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS 69

  Fly    77 FILAGFISMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSG 141
            |::|...|:||.|||.|||.||||.||||:|:|:::||.|||:.|||::|.:::|.:|||||||.
Human    70 FLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSA 134

  Fly   142 YVDSMLGGWIGN-TTLELTGGIHEPG-LAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVN 204
            ..|.::|..||. :...:|  ::.|| ||:.||:.|.::.::....|..|||.:|:.|.:.|.:|
Human   135 TFDELIGRPIGEFSRTHMT--LNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCIN 197

  Fly   205 IAVMVLVISVGFWYADGKNWSEAE-----------------------GGFLPYGVGGVIAGAATC 246
            :.|:..::..||.....|||...|                       |||:|:|..||::|||||
Human   198 VLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATC 262

  Fly   247 FYAFVGFDSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAF 311
            ||||||||.|||:|||.|||..:|||..|.||.:..:.|..||||||||:|...::..:.||:||
Human   263 FYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAF 327

  Fly   312 GQLNLSWAKYLISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVS 376
            ..:....|||.:::|:||.::.:||||:|.:||.:||||.|||||.....:|..|:.|::..:.|
Human   328 KHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLAS 392

  Fly   377 GVMSACLALVFDLAKLVEFMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDD-DDD 440
            |.::|.:|.:|||..||:.|||||||||::|:|.|::|||:|.:    ...|..:|.:.|: |..
Human   393 GAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQ----PNLVYQMASTSDELDPA 453

  Fly   441 DDEDVASQSSMDTS-SPTSEM--IEEVLAGRLKAQFRCLEPLLGRFEP----GSVVSVAVMLFIF 498
            |..::||.:..... .|.:||  ::.:|:.:             ..||    |.:|:::..|...
Human   454 DQNELASTNDSQLGFLPEAEMFSLKTILSPK-------------NMEPSKISGLIVNISTSLIAV 505

  Fly   499 LSFAICVELKVSWTQLYTGTWWALIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVP 554
            |....|:...:....|..|..||:    |::..:....||:.       |:|::.|
Human   506 LIITFCIVTVLGREALTKGALWAV----FLLAGSALLCAVVT-------GVIWRQP 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	220/556 (40%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	1/4 (25%)
SLC7A1	XP_016876202.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9129
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750