DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and Slc7a2

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001128158.1	Gene:	Slc7a2 / 64554	RGDID:	68387	Length:	658	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	254/629 - (40%)
Similarity:	362/629 - (57%)	Gaps:	66/629 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RTKSVPTDVME-TPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSFILAGFISM 85
            |.|.|..|.:| :.|.|||.|.|:..||:|..:|||:|||.|.|||..:||.|::||::|...|:
  Rat    16 RRKIVTLDSLEDSKLCRCLTTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASV 80

  Fly    86 LAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGYVDSMLGGW 150
            :|.|||||||.||||.||||:|||:::||.|||:.|||::|.:::|.:||||||||..|.:|...
  Rat    81 MAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQ 145

  Fly   151 IG---NTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVI 212
            ||   .|..::    :..|||:|||..|..:.::.|..|:.|||.:|..|...|.:||.|::.|:
  Rat   146 IGQFFKTYFKM----NYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVM 206

  Fly   213 SVGFWYADGKNWSEAE------------------------GGFLPYGVGGVIAGAATCFYAFVGF 253
            ..||...:..||..:|                        |||:|||..|.:|||||||||||||
  Rat   207 VAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGF 271

  Fly   254 DSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSW 318
            |.|||:|||.:||..:||:..|.||.|..:.|..||||||||:|...::..:.||.||..:....
  Rat   272 DCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGP 336

  Fly   319 AKYLISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACL 383
            |||:::.|:||.::|:||||:|.:||.:||||.|||||.|..:||..|:.|::..:.||.::|.:
  Rat   337 AKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAVM 401

  Fly   384 ALVFDLAKLVEFMSIGTLLAYTIVSASVIILRYRP---MERIHTTIRVPAVAGSPDDDDDDDEDV 445
            |.:|||..||:.||||||:||::|:|.|:||||:|   .|:...|               .::|:
  Rat   402 AFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYEQPKYT---------------PEKDI 451

  Fly   446 ASQSSMDTSSPTSEMIEEVLAGR---LKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAICVEL 507
            ....:..||...|::  .:|.|:   |:..|.  ...|...:..|:||..|....||...:.:..
  Rat   452 LESCTNATSKSESQV--TMLQGQGFSLRTLFN--PSALPTRQSASLVSFLVGFLAFLIAGLSILT 512

  Fly   508 KVSWTQLYTGTWWALIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMV 572
            ......:.....|:|.:....:......:..|....||.:.:.|.||.:||:||..|..||.|||
  Rat   513 TYGVQAIARLEAWSLALLALFLVLCAAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMV 577

  Fly   573 HLDAVTWVRFFVWVCIGMVVYFLYGIRNSKEG---------EVC 607
            .|.|.|||||.:|:.:|.::||.||||:|.||         :||
  Rat   578 QLSADTWVRFSIWMVLGFLIYFAYGIRHSLEGNPRDEEEDEDVC 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	246/604 (41%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	28/49 (57%)
Slc7a2	NP_001128158.1	2A0303	5..608	CDD:273330	250/614 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750