DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and SLC7A10

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011525421.1	Gene:	SLC7A10 / 56301	HGNCID:	11058	Length:	660	Species:	Homo sapiens

Alignment Length:	549	Identity:	104/549 - (18%)
Similarity:	185/549 - (33%)	Gaps:	160/549 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIIL-SFILAGFISMLAA 88
            :||.......|.:.:.......:.||:::|:||::....|.:.....|:.| .::|.|.::.|.:
Human    26 TVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGS 90

  Fly    89 LCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWN-ILLEHMLGAASVARAWSGYV-DSMLGGWI 151
            |||||.|..:||:|..|.|.....|....|::.|: :|:.:....|.::..:|.|| ..:....|
Human    91 LCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCI 155

  Fly   152 GNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVISVGF 216
            ..||..              .||:....::.....:..|:.......:.|...:..:.|:|.||.
Human   156 PPTTAS--------------RVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGL 206

  Fly   217 -----WYADGKNWSEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIPVATVI 276
                 .:.:....|.|...::...||.:........:||.|::.:....||..:...::|.|..|
Human   207 LQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFI 271

  Fly   277 SLFVVTVGYILVSAA-LTLMIPISEINPAA----------------SLPEAF------------- 311
            |:.:||..|...:.| .|.|.|...::..|                .||..:
Human   272 SIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVVSGPLLGPWLLPRPLPRPYTWPLYCAHPDLRG 336

  Fly   312 --------------GQLNL----------------------------------SWAK-------- 320
                          |.:||                                  .||:
Human   337 EAAGLLFLGHACLRGSVNLRRDQWLPVHLLQVTALGRRGHGEGRLGCRCAPVMPWARGRDTCRGR 401

  Fly   321 ------YLISIGALCGMTT-------------------TLLG--------------------SLF 340
                  .:|..|..|.:||                   .|||                    .::
Human   402 GLPEAGMMIPHGNKCLITTGRQRKQEAGRLDEGENCPVGLLGPEQEVRGDSLRGTSGPKLRPRMW 466

  Fly   341 ALP------RCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVEFMSIG 399
            .:|      |..::.|.:|.|.|....|:.....|:..|:|....:|.:.||.|...|:.::|..
Human   467 PVPISVPNARLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFI 531

  Fly   400 TLLAYTIVSASVIILRYRPMERIHTTIRV 428
            ..|.|.:....:::||:| ...:|..|:|
Human   532 NYLCYGVTILGLLLLRWR-RPALHRPIKV 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	102/542 (19%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
SLC7A10	XP_011525421.1	2A0308	15..635	CDD:273332	104/549 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850