DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13248 and slc7a14b

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_684639.2	Gene:	slc7a14b / 556696	ZFINID:	ZDB-GENE-091113-47	Length:	756	Species:	Danio rerio

Alignment Length:	738	Identity:	264/738 - (35%)
Similarity:	389/738 - (52%)	Gaps:	135/738 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GICTKMNRTKSVPT------DVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGI 73
            |:.:::.|||.|.:      |:..|.|...|.|.|:..||:|..||.|:||:.|.|||||||||:
Zfish    21 GLHSRILRTKPVDSMLEGSGDLHGTRLASVLTTVDLVSLGVGSCVGTGMYVVAGLVAKEMAGPGV 85

  Fly    74 ILSFILAGFISMLAALCYAEFGTRVPK-AGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVAR 137
            |||||:|...|:|:.:||||||.|||| .||||.|:|:::|||.||.||||::||:::|.|:.|.
Zfish    86 ILSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGAS 150

  Fly   138 AWSGYVDSMLGGWIGNTTLELTGGIHEPGLAQ--YPDVLAFLVCIVYAAALAGGVKATAVFNSLL 200
            |.|...||:....|....:...|.::..|..:  |||:||.|:.:|....:|.|||.:..||::|
Zfish   151 ALSSMFDSLANHTISRYMINHLGTLNGLGKGEESYPDLLALLIALVVTVIIALGVKNSVSFNNVL 215

  Fly   201 TLVNIAVMVLVISVGFWYADGKNWSEAEGG-FLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAK 264
            .:||:.|.|.::..|.::..|.||   ||| |||||..||:.|||||||||:|||.|||:|||||
Zfish   216 NVVNLVVWVFMVLAGLFFLSGANW---EGGRFLPYGWSGVMQGAATCFYAFIGFDIIATTGEEAK 277

  Fly   265 NPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISIGALC 329
            :|..|||.|...||......|:.||..|||::|.:.|:..|.|.|.|........||::::||:.
Zfish   278 SPDTSIPYAITASLVTCLTAYVSVSVILTLLVPYNLIDGDAPLMEMFADHGFLAGKYIVAVGAVA 342

  Fly   330 GMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVE 394
            |:|.:||||||.:||.:||||.|||||.....::|.|:.|::...|||.::|.|||:..|..|:|
Zfish   343 GLTVSLLGSLFPMPRVIYAMAGDGLLFRFLSFVSPHTETPVVACAVSGSLAALLALLVSLRDLIE 407

  Fly   395 FMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSE 459
            .||||||||||:||..|::|||:|.....|:.    :....:::....|::.:.|..|.:||..|
Zfish   408 MMSIGTLLAYTLVSVCVLLLRYQPDRDGFTSF----LTEEEEEERRRKEEMMAASEKDLNSPGGE 468

  Fly   460 --------------------MIEEVLAGRLKAQFR----------------CLEPLLGRF----- 483
                                :||:..:|..:::.:                ..:.:||..
Zfish   469 EYAENPCGAKNLPSKGDNETLIEKSDSGGYQSENQGYGVGENGIEVDDSDGLFKRVLGSHYYTIR 533

  Fly   484 ----------EP----GSVVSVAVMLFIFLSFAICVELKVSWTQLYTGTWWALIIYGF------- 527
                      :|    |..|:..|::|..|:|.:                |.|:||||
Zfish   534 MRLGLPNVSDKPTPATGRTVTSCVLIFFILTFFL----------------WTLVIYGFDRVSGGA 582

  Fly   528 ----------IIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAVTWVRF 582
                      ||....|.:.:|....:|.:.|.:..|.|||||...:..||.||:.|.::|||||
Zfish   583 RWAILPFILTIIVLMVTLLIIILRQPENPKKLPYMAPCVPFVPTAAMLVNIYLMLKLSSITWVRF 647

  Fly   583 FVWVCIGMVVYFLYGIRNSKEGEVCSSYSILMTTSEAGKVPWGSFKATSGGKKSSKHSIFERFTG 647
            .||..:|:::||.||:                         |.|....|..::::..|.::|:.
Zfish   648 VVWCSLGVLIYFSYGM-------------------------WNSSLELSAREEAAHASSYQRYD- 686

  Fly   648 RSKPEDKKSIVEE---SENETSG 667
             ::.:|..::.||   .|||..|
Zfish   687 -TEVDDSFNVEEELPPEENEEDG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	246/646 (38%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	23/49 (47%)
slc7a14b	XP_684639.2	2A0303	26..666	CDD:273330	252/687 (37%)
slc7a14b	XP_684639.2	AA_permease_C	616..666	CDD:290617	24/74 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820