DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and Slc7a4

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001100548.1	Gene:	Slc7a4 / 303787	RGDID:	1305905	Length:	635	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	272/641 - (42%)
Similarity:	400/641 - (62%)	Gaps:	40/641 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSSRRAILRHILSGICTKMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVA 65
            :||:.|      |:..|.|:||.|.:.....||.|.|||:|.|:.|||:|.|||:|:||||||||
  Rat     5 LPSTAR------LARFCQKLNRLKPLEESSTETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGTVA 63

  Fly    66 KEMAGPGIILSFILAGFISMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHML 130
            |:||||.::|||::|...|:||||||||||.|||:.||||::||:||||.|||:||||:|||:::
  Rat    64 KDMAGPAVLLSFLVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGEIWAFLIGWNVLLEYLI 128

  Fly   131 GAASVARAWSGYVDSMLGGWIGNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAV 195
            |.|:||||||||:|::....|.|.|....|....|.||.|||.||..:.:|.:|.::.|.:.::.
  Rat   129 GGAAVARAWSGYLDAIFNHSIRNFTESHMGVWQMPFLAHYPDFLAAGILLVASAFVSCGARVSSW 193

  Fly   196 FNSLLTLVNIAVMVLVISVGFWYADGKNWSEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSG 260
            .|...:.:::.|::.:|.:||..|...|||..||||.|:|..|::||.|||||||||||.||.|.
  Rat   194 LNHTFSAISLIVILFIIVLGFILARPHNWSAEEGGFAPFGFSGILAGTATCFYAFVGFDVIAASS 258

  Fly   261 EEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISI 325
            ||||||..::|:|..|||.:....|||||..||||:|...::|.::|.:||.:....||.:::::
  Rat   259 EEAKNPRWAVPMAIAISLGLAAGAYILVSTVLTLMVPWHSLDPDSALADAFYRRGYGWAGFIVAV 323

  Fly   326 GALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLA 390
            |::|.|.|.||.:||:|||.:||||:|||.|..|.:::|.||||::.::|.||:.|.|||:.||.
  Rat   324 GSICAMNTVLLSNLFSLPRIVYAMAADGLFFQVFARVHPRTQVPVVGILVFGVLMALLALLMDLE 388

  Fly   391 KLVEFMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSS 455
            .||:|:|||||||||.|:.|:|:||::              ..||...........:....|:.|
  Rat   389 ALVQFLSIGTLLAYTFVATSIIVLRFQ--------------KASPPSSPCPASPGPTVKKYDSFS 439

  Fly   456 PTSEMIEEVLA-----GRLKAQFRCLEPLLGRFE---PGSVVSVAVMLFIFLSFAICVELKVSWT 512
            ...::::.|.|     |:|:.   .|:|.||..:   ||:.|:.|:.:.|..:.::...|....:
  Rat   440 DHIQLVDAVQASMSEPGQLRP---ALKPFLGFLDGLSPGTAVTWALGILIASAISLACVLVFGNS 501

  Fly   513 QLYTGTW---WALIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHL 574
            .|:...|   ..|::.|.:..::   :.|:..|.|..:...|::||||..|||.|..|:.||:.|
  Rat   502 ALHLPRWGYVLLLVVSGAVFLSS---LLVLGAHQQQKKQDTFQIPLVPLTPALSILLNLCLMLKL 563

  Fly   575 DAVTWVRFFVWVCIGMVVYFLYGIRNSKEGEVCSSYSILMTTSEAGKVPWGSFKAT 630
            ..:||:||..|:.:|:||||.|||.:|||.:   ...:.:||:.....|.||.:.|
  Rat   564 SYLTWLRFIFWLLVGLVVYFGYGIWHSKENQ---REPLELTTAHYVVFPSGSLEET 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	255/581 (44%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	26/49 (53%)
Slc7a4	NP_001100548.1	2A0303	14..592	CDD:273330	260/597 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	418	1.000	Domainoid score	I631
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20883
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1275
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D290636at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		oto96565
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	LDO	PTHR43243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840