DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and Slc7a12

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001011948.1	Gene:	Slc7a12 / 294881	RGDID:	1309208	Length:	472	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	113/538 - (21%)
Similarity:	209/538 - (38%)	Gaps:	136/538 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LNRCLNTFDIALLGIGHMVGAGIYVLTGTVAK--EMAGPGIILSFILAGFISMLAALCYAEFGTR 97
            |.|.|..|.:.:......:|.||:|....|.|  .:..|..:..:...|.:||:.|:|.||....
  Rat     3 LLRGLGFFHVNMFLFSATIGTGIFVSPKGVLKYCSLNIPIFLSIWAGCGLLSMMNAVCLAEIAAT 67

  Fly    98 VPKAGSAYVYTYISMGEFWAFVIGW--------NILLEHMLGAASVARAWSGYVDSMLGGWIGNT 154
            .|.:|::|.:...::|...||:..|        .|..:.:|.|:|:.:.:  |.:
  Rat    68 YPVSGASYYFLKRALGSSVAFLSIWIKIFACTLGISAQCLLIASSLIQCF--YSE---------- 120

  Fly   155 TLELTGGIHEPGLAQYPDV----LAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVISVG 215
                         .|.|::    ||..:...:....|.|:|..|.||::.:|:.::|:.|:...|
  Rat   121 -------------CQAPELPKKCLALAILWSFGILSARGIKPVAWFNTISSLMKLSVLCLISLTG 172

  Fly   216 F-WYADGKNWS--------EAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIP 271
            . ....||..:        |||   || .|..:.......:||::|...:.....|.|.|:.:||
  Rat   173 IVLLVIGKKENVSRFEKALEAE---LP-NVSQIAEAILQVYYAYLGSSFLIVIAGEIKRPAETIP 233

  Fly   272 VATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLN-----LSWAKYLISIGALCGM 331
            .:.:..|.||||.|:|.:.:...::...||..:.|:  |...:|     :.|...|:....|.|.
  Rat   234 KSIIYGLSVVTVLYLLTNVSFLAVLTSEEIISSDSV--AVTWMNRVFPSMQWIISLLISAFLFGS 296

  Fly   332 TTTLLGSLFALPRCMYAMASDG---LLFSCFGKINPTTQVPLLNLVVS--GVMSACLALVFDLAK 391
            .:.   .:.:..|..||.:.:|   .::|....::......|..:::|  |::|:      ::..
  Rat   297 VSC---GIVSASRIFYATSQEGQFPFIYSMLNDLHSPVVADLQAVILSSVGIISS------NMIY 352

  Fly   392 LVEFMSIGTLLAYTIVSASVIILRY------RPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSS 450
            |::::.:||.....:....::.|||      ||.:     :|:|.|.||          :||
  Rat   353 LIKYVGLGTWCLNLLNMIGLLKLRYQNPDLPRPYK-----VRLPFVFGS----------IAS--- 399

  Fly   451 MDTSSPTSEMIEEVLAGRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAICVELKVSWTQLY 515
                                :.|..|.|::   :..|...|..::|:|... :|.     |.|.|
  Rat   400 --------------------SLFLILTPVI---QSPSTEHVYQVVFLFCGL-LCY-----WLQAY 435

  Fly   516 TG----------TWWALI 523
            ..          .:|.|:
  Rat   436 LNRHGVCFNRITCYWQLL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	113/538 (21%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
Slc7a12	NP_001011948.1	2A0308	21..423	CDD:273332	101/482 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000