DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and Slc7a3

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_058913.1	Gene:	Slc7a3 / 29485	RGDID:	68342	Length:	619	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	251/621 - (40%)
Similarity:	362/621 - (58%)	Gaps:	77/621 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSFILAGFI 83
            |:.|.:.:...:.||.|.|||:|.|:..||:|..:|||:|||.|.||||.|||.|::.|::|...
  Rat    12 KLVRRRLLELGMGETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKEKAGPSIVICFLVAALS 76

  Fly    84 SMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGYVDSMLG 148
            |:||.|||||||.|||.:||||:|:|:::||.|||..|||::|.:::|.||||||||...|:::|
  Rat    77 SVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIG 141

  Fly   149 GWIGNTTLELTGGIHEPG-LAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVI 212
            ..| :.||:.|..::.|. ||:|||..|..:.::....|..|...:.:...:.|.:|:.|:..||
  Rat   142 NHI-SQTLKGTILLNMPHVLAEYPDFFALALVLLLTGLLVLGANESGLVTKVFTGMNLLVLGFVI 205

  Fly   213 SVGFWYADGKNW---------------------SEAEGGFLPYGVGGVIAGAATCFYAFVGFDSI 256
            ..||...:.:||                     |...|||:|:|:.|::.|||||||||||||.|
  Rat   206 ISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFYAFVGFDCI 270

  Fly   257 ATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKY 321
            ||:||||:||..|||:..||||.:..:.|..||:|||||:|..::.|.:.|||||..:....|:|
  Rat   271 ATTGEEAQNPQRSIPMGIVISLSICFLAYFGVSSALTLMMPYYKLQPESPLPEAFTYVGWEPARY 335

  Fly   322 LISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALV 386
            |::||:||.::|:||||:|.:||.:||||.|||||....:::..|..|::..|||||::|.:|.:
  Rat   336 LVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARVHNGTHTPIVATVVSGVIAAFMAFL 400

  Fly   387 FDLAKLVEFMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSM 451
            |:|..||:.|||||||||::||..|:||||:|.:.:                .:.:|:|..|...
  Rat   401 FELTDLVDLMSIGTLLAYSLVSICVLILRYQPDQEM----------------KNGEEEVELQEER 449

  Fly   452 DTSSPTSEMIEEVLAGRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAICVELKVSWTQLYT 516
            ...:      |::....|..|...:..||.    |.:|.|...|...|...:|:.|
  Rat   450 TLEA------EKLTVQALFCQVDSIPTLLS----GRIVYVCSSLLAVLLTVLCLVL--------- 495

  Fly   517 GTWW--------------ALIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCN 567
             |||              .::|.|.|:..:|    ||....||...|.||||:||.:|.:.||.|
  Rat   496 -TWWTTPLHSGDPVWVTVVVLILGLILGISG----VIWRQPQNRTPLHFKVPVVPLLPLVSIFVN 555

  Fly   568 ILLMVHLDAVTWVRFFVWVCIGMVVYFLYGIRNSKE 603
            :.||:.:.|.||.||.||:.||..:||.|||::|.|
  Rat   556 VYLMMQMTADTWARFGVWMLIGFAIYFGYGIQHSVE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	248/606 (41%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	26/49 (53%)
Slc7a3	NP_058913.1	2A0303	4..591	CDD:273330	250/619 (40%)
Slc7a3	NP_058913.1	AA_permease_C	<551..589	CDD:290617	19/37 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720