DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and Slc7a1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_037243.2	Gene:	Slc7a1 / 25648	RGDID:	3716	Length:	624	Species:	Rattus norvegicus

Alignment Length:	614	Identity:	255/614 - (41%)
Similarity:	375/614 - (61%)	Gaps:	45/614 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSFILAGFISML 86
            |.|.|.....|:.|:|||||:|:..||:|..:|||:|||.|.||:|.|||.|::||::|...|:|
  Rat    15 RRKVVDCSREESRLSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVL 79

  Fly    87 AALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGYVDSMLGGWI 151
            |.|||.|||.||||.||||:|:|:::||.|||:.|||::|.:::|.:|||||||...|.::|..|
  Rat    80 AGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGKPI 144

  Fly   152 GNTTLELTGGIHEPG-LAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVISVG 215
            |..:.:.. .::.|| |||.||:.|.::.|:....|..|||.:|:.|.:.|.:|:.|:..::..|
  Rat   145 GEFSRQHM-ALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVLVLCFIMVSG 208

  Fly   216 FWYADGKNW------------------SEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEE 262
            |.....:||                  ...||||:|:|..||::|||||||||||||.|||:|||
  Rat   209 FVKGSIENWQLTENKSSPLCGNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEE 273

  Fly   263 AKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISIGA 327
            .|||..:|||..|.||.:..:.|..||||||||:|...::..:.||.||.......|||.:::|:
  Rat   274 VKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDTDSPLPGAFKYRGWEEAKYAVAVGS 338

  Fly   328 LCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKL 392
            ||.::|:||||:|.:||.:||||.|||||....|||..|:.|::..|.||.::|.:|.:|:|..|
  Rat   339 LCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKINDRTKTPIIATVTSGAIAAVMAFLFELKDL 403

  Fly   393 VEFMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDD--DDDEDVASQSSMDTSS 455
            |:.|||||||||::|:|.|::|||:|.:    ...|..:|.:.|:.|  |.:|.|::..|.....
  Rat   404 VDLMSIGTLLAYSLVAACVLVLRYQPEQ----PNLVYQMARTTDELDQVDQNEMVSASESQTGFL 464

  Fly   456 PTSE--MIEEVLAGRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAICVELKVSWTQLYTGT 518
            |.:|  .::.:|:.      :.:||  .:|. |.:|:::..|...|...:|:...:....|..||
  Rat   465 PAAEKFSLKTILSP------KNMEP--SKFS-GLIVNISAGLLAVLIITVCIVAVLGREALAEGT 520

  Fly   519 WWAL-IIYGFIIFAAGTCVAVIAV---HNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAVTW 579
            .||: ::.|.::.    |:.|..:   ..::...|.||||.||.:|.|.||.||.||:.||..||
  Rat   521 LWAVFVMTGSVLL----CMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSIFVNIYLMMQLDQGTW 581

  Fly   580 VRFFVWVCIGMVVYFLYGIRNSKEGEVCS 608
            |||.||:.||..:||.||..:|:|..:.:
  Rat   582 VRFAVWMLIGFAIYFGYGAWHSEEASLAA 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	251/597 (42%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	29/49 (59%)
Slc7a1	NP_037243.2	2A0303	4..605	CDD:273330	254/607 (42%)
Slc7a1	NP_037243.2	AA_permease_C	553..603	CDD:290617	29/49 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720