DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and F23F1.6

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_493642.1	Gene:	F23F1.6 / 184903	WormBaseID:	WBGene00017747	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	609	Identity:	256/609 - (42%)
Similarity:	365/609 - (59%)	Gaps:	65/609 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 METPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSFILAGFISMLAALCYAEFG 95
            :|:.:.|||...|:..:.||||:|||||||||:|.:..|||.||||||.:||.::|:|..|||||
Worm    22 LESQMKRCLTILDVMFIAIGHMIGAGIYVLTGSVVRNQAGPAIILSFIFSGFAALLSAFSYAEFG 86

  Fly    96 TRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGYVDSMLGGWIGNTTLELTG 160
            .|.|:|||||.|:|:.|||.|||::||.:.||:|:|.|:|||:||.|.|:::...:.|.||:..|
Worm    87 ARFPRAGSAYTYSYVGMGEIWAFIVGWTVPLEYMIGNAAVARSWSAYFDNLVSKSVSNWTLDTVG 151

  Fly   161 GIHEPG--LAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVISVGFWYADGKN 223
            .:.:..  .|.|||.|||.:..:.|.|:|.|.|.:|..|:....:|:||:..||..|..|||...
Worm   152 RLSDGKGFFALYPDFLAFFLLFLVAVAVAMGSKFSANVNTSFVFLNLAVLAFVIICGLTYADFSL 216

  Fly   224 WS----EAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIPVATVISLFVVTVG 284
            ||    :....|.|||:.|.|:||:|||:||:||:::||:|||||||..:||:||..||.:::|.
Worm   217 WSGTYQDGRSKFFPYGIQGAISGASTCFFAFIGFEALATAGEEAKNPHRTIPLATFTSLAIISVI 281

  Fly   285 YILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISIGALCGMTTTLLGSLFALPRCMYAM 349
            |:|:.|:||||||...::|.|:...||.....:.||.::|:|||.||...|:...|||||.:|||
Worm   282 YVLMGASLTLMIPYDLVDPDAAFAAAFEMKGATVAKIIMSVGALAGMLNNLVTGSFALPRAVYAM 346

  Fly   350 ASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVEFMSIGTLLAYTIVSASVIIL 414
            |.|||:|..||.||..|:.||...:|..:::|.|||||||..||:|:||||||||::||..||||
Worm   347 ADDGLIFGWFGVINSKTKTPLNATIVFTIINAILALVFDLQALVDFLSIGTLLAYSMVSICVIIL 411

  Fly   415 RYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSEMIEEVLAGRLKAQFRCLEPL 479
            |::.    |      .|.||..|.|:                         .|.||:..    |.
Worm   412 RHQS----H------LVDGSATDYDN-------------------------GGCLKSWV----PF 437

  Fly   480 LG---RFEPGSVVSVAVMLFIFLSFAICVELKVSWTQLYTGTWWALIIYGFIIFAAGTCVAVIAV 541
            .|   .|..|..:.|||...||....:.:..:   |.:::...      |.|:...|...::::.
Worm   438 QGVWENFSEGISIRVAVAGLIFGYICLAIPFR---TGIFSNAG------GIILLTVGAAFSLLSF 493

  Fly   542 -----HNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAVTWVRFFVWVCIGMVVYFLYGIRNS 601
                 |.||.....:|||||||:|.||:..|:.:||:|:::||:|.|||:.||:|:|..||||:|
Worm   494 VFILGHEQNKSTSTYKVPLVPFIPCLGLLINVFMMVYLNSMTWIRLFVWLAIGIVIYICYGIRHS 558

  Fly   602 KEGEVCSSYSI---LMTTSEAGKV 622
            |||:..|...:   :|:.:...||
Worm   559 KEGQKLSKIDVHNEIMSRTSDTKV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	249/584 (43%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	28/49 (57%)
F23F1.6	NP_493642.1	2A0303	1..560	CDD:273330	249/585 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	463	1.000	Domainoid score	I228
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I630
Isobase	1	0.950	-	0	Normalized mean entropy	S2810
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D290636at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		otm14275
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790