DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and B0454.6

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_494428.1	Gene:	B0454.6 / 173650	WormBaseID:	WBGene00015197	Length:	585	Species:	Caenorhabditis elegans

Alignment Length:	616	Identity:	250/616 - (40%)
Similarity:	359/616 - (58%)	Gaps:	53/616 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILSGICTKMNRTKSVPTDV-METPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIIL 75
            ::|.:...:.|.|....|. :::.|.|||...||..|.:|.|:|||||||||||.:..|||.||.
Worm     1 MVSHVWQAITRKKRFEGDSHLDSNLRRCLGLMDITFLALGQMMGAGIYVLTGTVVRNQAGPSIIF 65

  Fly    76 SFILAGFISMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWS 140
            ||.|||..::|:|..|||||.|.|:|||||.||||..||.|||::||.|.||:|:|.|:|||:||
Worm    66 SFALAGIAALLSAFSYAEFGARFPRAGSAYTYTYIGFGELWAFIVGWTIPLEYMIGNAAVARSWS 130

  Fly   141 GYVDSMLGGWIGNTTLELTGGIHEPG--LAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLV 203
            .|.|:||..:|.|||:...|.:.|||  .:.|||:|:||:..:.|..:|.|.|.:|..||...::
Worm   131 AYFDNMLDNYIKNTTIGALGELSEPGGFFSTYPDILSFLLICLCACVIAVGPKVSANVNSSFVVL 195

  Fly   204 NIAVMVLVISVGFWYADGKNW----SEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAK 264
            ||.|:.:||..|..|||..||    |:....|.|:|:.|.:.||||||::::||:.:||:|||.|
Worm   196 NIVVIFIVIVSGICYADFNNWTGTTSDGRSMFFPFGLTGTLTGAATCFFSYIGFEVLATAGEEVK 260

  Fly   265 NPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISIGALC 329
            :|..:|||||.:|:.|:...|||||:.||||:|..:::..|...|||.....:...|:||||||.
Worm   261 SPHRTIPVATFLSIGVIMTLYILVSSTLTLMVPYDQVHTTAPFAEAFSARGCTTVMYIISIGALI 325

  Fly   330 GMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVE 394
            |:|..|:..:|||||.:||||.|||:|.....:..:|:|||..:|:..:::|.:||:||:..|||
Worm   326 GLTNNLVTGVFALPRAVYAMADDGLIFKWLAHVTSSTKVPLNAIVIFTLLNAIIALIFDIEALVE 390

  Fly   395 FMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSE 459
            |:|||||.||:.||.||::|||:               .:|.|.|.        ..||.....|.
Worm   391 FLSIGTLFAYSFVSGSVLVLRYQ---------------SAPIDGDG--------KRMDNGGELSS 432

  Fly   460 MIEEVLAGRLKAQFRCLEPLLGRFE---PGSVVSVAVMLFIFLSFAICVELKVSWTQLYTGTWWA 521
            .|                |....:|   .|:.:|:.|...|...|.:....:..:.:    .|:.
Worm   433 WI----------------PARNFWESLPAGTSISLGVAALIGSFFWLAFTFRTGFYE----HWYG 477

  Fly   522 LIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAVTWVRFFVWV 586
            .|..||........:|.|..|.||:....||||.|||:|.|.:..|:.:|.:|...||:|.|||:
Worm   478 QISIGFNGLLIVLVMAFILGHQQNSLETSFKVPFVPFLPCLSLLVNVFMMAYLTTATWIRLFVWM 542

  Fly   587 CIGMVVYFLYGIRNSKEGEVCSSYSILMTTS 617
            .:|:::||.||||:|||.:..::.:.:..:|
Worm   543 GVGLLIYFSYGIRHSKEAKKLTTIADIRMSS 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	243/579 (42%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	25/49 (51%)
B0454.6	NP_494428.1	2A0303	7..559	CDD:273330	246/594 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I5742
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I630
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D290636at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		otm14275
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840