DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and Slc7a1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001288353.1	Gene:	Slc7a1 / 11987	MGIID:	88117	Length:	622	Species:	Mus musculus

Alignment Length:	625	Identity:	260/625 - (41%)
Similarity:	378/625 - (60%)	Gaps:	51/625 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSGICTKMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSF 77
            |.|:..:|.|.|.|.....|:.|:|||||:|:..||:|..:|||:|||.|.||:|.|||.|::||
Mouse     6 LLGLGQQMLRRKVVDCSREESRLSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISF 70

  Fly    78 ILAGFISMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGY 142
            ::|...|:||.|||.|||.||||.||||:|:|:::||.|||:.|||::|.:::|.:|||||||..
Mouse    71 LIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSAT 135

  Fly   143 VDSMLGGWIGNTTLELTGGIHEPG-LAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIA 206
            .|.::|..||..:.:.. .::.|| |||.||:.|.::.|:....|..|||.:|:.|.:.|.:|:.
Mouse   136 FDELIGKPIGEFSRQHM-ALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVL 199

  Fly   207 VMVLVISVGFWYADGKNW----------------SEAEGGFLPYGVGGVIAGAATCFYAFVGFDS 255
            |:..::..||.....|||                ...||||:|:|..||::|||||||||||||.
Mouse   200 VLCFIVVSGFVKGSIKNWQLTEKNFSCNNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFDC 264

  Fly   256 IATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAK 320
            |||:|||.|||..:|||..|.||.:..:.|..||||||||:|...::..:.||.||.......||
Mouse   265 IATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDIDSPLPGAFKHQGWEEAK 329

  Fly   321 YLISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLAL 385
            |.::||:||.::|:||||:|.:||.:||||.|||||....|||..|:.|::..|.||.::|.:|.
Mouse   330 YAVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKINNRTKTPVIATVTSGAIAAVMAF 394

  Fly   386 VFDLAKLVEFMSIGTLLAYTIVSASVIILRYRP------MERIHTTIRVPAVAGSPDDDDDDDED 444
            :|:|..||:.|||||||||::|:|.|::|||:|      .:...||..:..|        |.:|.
Mouse   395 LFELKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMARTTEELDRV--------DQNEL 451

  Fly   445 VASQSSMDTSSPTSE--MIEEVLAGRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAICVEL 507
            |::..|.....|.:|  .::.:|:.      :.:||  .:|. |.:|:::..|...|...:|:..
Mouse   452 VSASESQTGFLPVAEKFSLKSILSP------KNVEP--SKFS-GLIVNISAGLLAALIITVCIVA 507

  Fly   508 KVSWTQLYTGTWWAL-IIYGFIIFAAGTCVAVIAV---HNQNTRGLIFKVPLVPFVPALGIFCNI 568
            .:....|..||.||: ::.|.::.    |:.|..:   ..::...|.||||.||.:|.|.||.||
Mouse   508 VLGREALAEGTLWAVFVMTGSVLL----CMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSIFVNI 568

  Fly   569 LLMVHLDAVTWVRFFVWVCIGMVVYFLYGIRNSKEGEVCS 608
            .||:.||..|||||.||:.||..:||.|||.:|:|..:.:
Mouse   569 YLMMQLDQGTWVRFAVWMLIGFTIYFGYGIWHSEEASLAA 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	253/599 (42%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	30/49 (61%)
Slc7a1	NP_001288353.1	2A0303	4..603	CDD:273330	259/618 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9086
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750