DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and slc7a14

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_002931595.1	Gene:	slc7a14 / 100493085	XenbaseID:	XB-GENE-1010371	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	758	Identity:	259/758 - (34%)
Similarity:	392/758 - (51%)	Gaps:	113/758 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RRAILRHILSGICTKMNRTKSVP--------TDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLT 61
            ||...|.......::..|||.|.        |....|.|.|.|.|.|:..||:|..||.|:||::
Frog    11 RRIPWRATWHAFSSRTLRTKPVESMLEGTAGTSAHGTKLARVLTTLDLVSLGVGSCVGTGMYVVS 75

  Fly    62 GTVAKEMAGPGIILSFILAGFISMLAALCYAEFGTRVPK-AGSAYVYTYISMGEFWAFVIGWNIL 125
            |.|||||||||:|:|||:|...|:|:.:||||||.|||| :||||.|:|:::|||.||.||||:|
Frog    76 GMVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTSGSAYTYSYVTVGEFVAFFIGWNLL 140

  Fly   126 LEHMLGAASVARAWSGYVDSMLGGWIGNTTLELTGGIHEPGLAQ--YPDVLAFLVCIVYAAALAG 188
            ||:::|.||.|.|.|...||:....|.:..:...|.::..|..:  |||.:|.::.|:....:|.
Frog   141 LEYLIGTASGASALSSMFDSLANYTISHWMITNVGTLNGLGKGEDSYPDFIALVIAIIVTIIVAL 205

  Fly   189 GVKATAVFNSLLTLVNIAVMVLVISVGFWYADGKNWSEAEGGFLPYGVGGVIAGAATCFYAFVGF 253
            |||.:..||::|.::|..|.:.::..|.:|.:|||||   |.|||||..||:.|||||||||:||
Frog   206 GVKNSVGFNNVLNVINFLVWIFIMIAGLFYVNGKNWS---GDFLPYGWSGVMTGAATCFYAFIGF 267

  Fly   254 DSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSW 318
            |.|||:|||||:|:.|||.|...||......|:.||..|||.:|.:.|:..:.|.|.|.......
Frog   268 DIIATTGEEAKSPNTSIPYAITASLITCLTAYVSVSVILTLAVPYNMIDTESPLMEMFVVHGFYA 332

  Fly   319 AKYLISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACL 383
            ||:::::|::.|:|.:|.||||.:||.:||||.|||||.....::..|:.|::..||||.::..|
Frog   333 AKFVVAVGSVAGLTVSLFGSLFPMPRVIYAMAGDGLLFKFLAHVSSYTETPVVACVVSGFLAGLL 397

  Fly   384 ALVFDLAKLVEFMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQ 448
            :|:..|..|:|.||||||||||:||..|::|||:|...|...::..:     :::....|.:.:.
Frog   398 SLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFIS-----EENTKKKEGILAD 457

  Fly   449 SSMDTSSPTSEMIE--------------------EVLAGRL-KAQFRCLEPLLGRFE-------- 484
            ...|..||.|:..|                    |:|.|:. |:.:....|..|..:
Frog   458 CEKDACSPMSDGEEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSHYNINHPNYGTVDMTSGIEAD 522

  Fly   485 ---------------------------PGSV----------VSVAVMLFIFLSFAICVELKVSWT 512
                                       ||.:          |::.|:|...|....|..:..:..
Frog   523 GSENRYLFKIKKFIGPRYYTLRIRLGLPGKMDRPTAATGRTVTICVILLFLLILIFCSFIIFAAD 587

  Fly   513 QLYTGTWWALIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAV 577
            .:|...|||:::...::......|.||....:|.:.|.:..|.||||||..:..|:.||:.|.::
Frog   588 YIYEQAWWAILLVVLMVLLLFALVFVILQQPENPKKLPYMAPCVPFVPAFAMLVNVYLMLKLSSI 652

  Fly   578 TWVRFFVWVCIGMVVYFLYGIRNS----------------KEGEVCSSYSI---LMTTSEAGKVP 623
            ||:||.:|..:|:::||.||:.||                :..:|..::|:   ....||.....
Frog   653 TWIRFAIWCFVGLLIYFGYGMWNSTLEISAREEVLHQSTYQRYDVDDNFSVDDGFSYPSEENFQD 717

  Fly   624 WGSFKATSGGKKSSKHSIFERFTG----RSKPEDKKSIVEESE 662
            ||..:.     |.|.:....:..|    .|:|:.|:...::|:
Frog   718 WGGTET-----KDSYYQQDPKTEGNSQMNSRPKSKRKHKQDSD 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	238/655 (36%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617	21/49 (43%)
slc7a14	XP_002931595.1	2A0303	20..676	CDD:273330	241/663 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000