DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33969 and Fbxw4

DIOPT Version :9

Sequence 1:	NP_001034034.1	Gene:	CG33969 / 40252	FlyBaseID:	FBgn0053969	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	XP_038936327.1	Gene:	Fbxw4 / 309444	RGDID:	1306518	Length:	570	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	84/332 - (25%)
Similarity:	137/332 - (41%)	Gaps:	80/332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ERIELSRNWVSGTYFERPY--FHHAQMFPTKLCLEADFLYITHACYLRKYR-RSSCDALHRR--- 135
            ||::||:||..|...:|..  :.::||  ..:.||...||::.|.::..|: |....:|:||
  Rat   300 ERVKLSQNWRLGRCRDRILLKWRYSQM--PWMQLEDSSLYLSQANFILAYQFRPDGASLNRRPFR 362

  Fly   136 ----FDEEICTSAQTDISDFVKKNETIFAGRVCGSCFHYDTDSMVMTEQRMHPANEYLYCVDFVK 196
                .||::|        .||..|..|.:....|....:...|....:...|  .:.:.|||...
  Rat   363 VFAGHDEDVC--------HFVLANSHIISAGGDGKIGVHKIHSTFTVKYSAH--EQEVNCVDCKG 417

  Fly   197 DLYAT-STDHCCRLWQRAQEFGMTHFDQVMHLPHAFRSLELSSDGQWLYGGLYTDNGRQALRAVH 260
            .:..: |.|...::|                 |.|...|     ||.|                |
  Rat   418 GIIVSGSRDRTAKVW-----------------PLASGQL-----GQCL----------------H 444

  Fly   261 VESGEELVFS---SKTMSIYDLKLKDDQVIFTA---NFDSTFRMFDRRVDRDVAIWDDPFDSSFY 319
            ....|:.|:|   |..:|.:        |..||   :| |..|::| ...:.|..|::|.||:||
  Rat   445 TIQTEDRVWSIAISPVLSSF--------VTGTACCGHF-SPLRIWD-LTRKCVMEWEEPHDSTFY 499

  Fly   320 SLEYDGLHAVLVGTNRHARVNLYDIRMKKYVQLYFPGRTRSHNGLSPVYSLACDSQYMFVATDHN 384
            .|:.||.|.:..|::.:..|.|:|.|.:..:.. ||  ..|....||||.|...:::::.|..:|
  Rat   500 CLQTDGNHLLATGSSYYGLVRLWDRRQRACLHA-FP--LTSTPLSSPVYCLRFTTRHLYAALSYN 561

  Fly   385 MRVFDFK 391
            :.|.||:
  Rat   562 LHVLDFE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33969	NP_001034034.1	WD40	<146..345	CDD:225201	47/205 (23%)
CG33969	NP_001034034.1	WD40	183..391	CDD:295369	54/214 (25%)
Fbxw4	XP_038936327.1	F-box-like	233..274	CDD:403981
		WD40	313..549	CDD:421866	72/298 (24%)
		WD40 repeat	371..403	CDD:293791	7/39 (18%)
		WD40 repeat	411..445	CDD:293791	12/71 (17%)
		WD40 repeat	452..491	CDD:293791	12/48 (25%)
		WD40 repeat	499..538	CDD:293791	12/41 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5222
OMA	1	1.010	-	-		QHG49778
OrthoDB	1	1.010	-	-		D320419at33208
OrthoFinder	1	1.000	-	-		FOG0008136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108554
Panther	1	1.100	-	-	LDO	PTHR14381
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.810