DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5498 and chmp7

DIOPT Version :9

Sequence 1:	NP_730525.2	Gene:	CG5498 / 40250	FlyBaseID:	FBgn0027565	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_957075.1	Gene:	chmp7 / 393754	ZFINID:	ZDB-GENE-040426-1750	Length:	457	Species:	Danio rerio

Alignment Length:	461	Identity:	118/461 - (25%)
Similarity:	206/461 - (44%)	Gaps:	61/461 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FPASWQDNGRMQVQFAMFR-SRHLDAEGYDAKMNFWMDLIAKYLKFSGRPIFSLRDLQLLFMRGD 80
            ||..|.|:.||...|:.|: :|.:|...:|.|::||..||.::.:..|....:|:||...|.|..
Zfish    12 FPPDWDDDERMSFLFSAFKENRDVDCTDWDGKIDFWSPLIIEHCRRCGSVCVNLQDLNENFRRKG 76

  Fly    81 QLPACLDTVISEMQQRKQIRSRSEFEYDPANSWGGWLVNSLVKRPLSWSWSKIKHSVVTEDLEAS 145
            .:|..|.|||..|.:..:::..|:|..:..:.|..|.|..|:.|||.|:.|.:..|......|:.
Zfish    77 SVPLGLSTVIQSMIRSGKVQKESDFAANVDSGWLSWGVGLLLVRPLKWTLSALLGSGRVPLEESF 141

  Fly   146 ALIEWIHLDALNNTCDLIAE---KVLSENTGKLLHFNALKTLCKTHGVPTYSDKDLCACLLALNV 207
            .:||.:.    ....:|:|.   ..||..:  ||.|..|::| .:|..|  .:..||..||.|
Zfish   142 VVIELVK----EKAAELLAAYRGSALSARS--LLSFQELRSL-SSHICP--DESTLCMALLQL-- 195

  Fly   208 RQILGLEFKVEKGIR-QIH----LIKIPKK-PGDDLNISQEDQAVHNLQNTQAQLLKQLEDLEEE 266
                    :.||.:. .:|    |:|..:. .|....:|:.|..::.||.::..|.:::|.|..|
Zfish   196 --------QREKHVTVSLHEGEKLVKFSQAGQGRVSPVSEVDLGIYQLQCSEKLLEERVEALGHE 252

  Fly   267 IKVNDDKVRQYMKENKRQMAKTYLRKRHLLEKNHERRSLALHNIESLLSSVDEAQNSGVVLDAYK 331
            .:....:.:..:||.|:..|...||....:||..:|....|..::.:|..:..:|...:|:.||:
Zfish   253 AEKCKQQAKSLLKEGKKSQALRCLRGSKRVEKKADRLFAQLETVKGILDRIANSQTDRLVMQAYQ 317

  Fly   332 IGSNTLKKVLSNSGLKYDNVDEVLADVRDTLDQHREVQDIMSNSVVENASQEDDQLEQELRELAG 396
            .|...|:  :|..|:..:..:.::..:::..|...||...:: |...:|.::.:.||:||:.|..
Zfish   318 AGVAALR--ISLKGVTVERAENLVDQIQELCDTQDEVNQTLA-SGAPDAGEDSEDLEEELKSLME 379

  Fly   397 ESAP--------------------------ATFSPHINNNLRAEVVITDEEMIAMLQDLEVEDGT 435
            :|.|                          ..|.|.:.|   ..:.|||||:...|:.|.|.|..
Zfish   380 KSVPENDLFPAVPTHPITPPRKTDLPDAAFVQFLPSVPN---PGMNITDEELDRELRRLTVSDKG 441

  Fly   436 VSQSSV 441
            :.:.||
Zfish   442 LPRESV 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5498	NP_730525.2	Snf7	244..397	CDD:304451	35/152 (23%)
chmp7	NP_957075.1	Snf7	232..>357	CDD:304451	28/126 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..401		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..457		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8499
eggNOG	1	0.900	-	-		E1_KOG2911
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14613
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4602
OMA	1	1.010	-	-		QHG56027
OrthoDB	1	1.010	-	-		D551620at33208
OrthoFinder	1	1.000	-	-		FOG0004474
OrthoInspector	1	1.000	-	-		oto40344
orthoMCL	1	0.900	-	-		OOG6_104244
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3927
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770