DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and RHOBTB1

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001229288.1	Gene:	RHOBTB1 / 9886	HGNCID:	18738	Length:	696	Species:	Homo sapiens

Alignment Length:	717	Identity:	299/717 - (41%)
Similarity:	412/717 - (57%)	Gaps:	74/717 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
Human     5 MDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERS 69

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|:||||||||||||.|||||||||||||:||||||:|.||.:.|.||||||:.|||..|
Human    70 RDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTP 134

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            ||||||:.||||     :.|....|:         |...:.|::.|::.|.||||||:.||||||
Human   135 VILVGCQLDLRYADLEAVNRARRPLA---------RPIKRGDILPPEKGREVAKELGLPYYETSV 190

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTVMVGNYRQDIY 258
            |..||:.:||:||||:|||:||..:||.::|||||||||||||.|||.|||.:.:      .:..
Human   191 FDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKI------PECP 249

  Fly   259 NMFLSQA--------YTDLVLVGAGGTKFAVHRFMLAAASSIFQR--LLSTELTDMGGRSSSESS 313
            :|..::|        ..|::.:.........||..||.:||.|..  |:..|.:..|...:.|..
Human   250 SMGTNEAACLLDNPLCADVLFILQDQEHIFAHRIYLATSSSKFYDLFLMECEESPNGSEGACEKE 314

  Fly   314 MVSSTF-GEATIADFNDDTE-------ALIRYESRTQRMWEHLKRRSSYQALPLME-----SKRS 365
            ..|..| |.....|..::.|       ...:::|..:.:.|.|...:. .|:|..:     ||..
Human   315 KQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSNKSLVEALGLEAE-GAVPETQTLTGWSKGF 378

  Fly   366 NDLYRELH-HPVLQSIRLVHVENHRGVNGLQTIVTLSKLISPQALHQCLRFIYTGTID---KDCD 426
            ..::||:. :|:.:.:            |..|:|.:...:.|......|:|:|||.:|   ||..
Human   379 IGMHREMQVNPISKRM------------GPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLV 431

  Fly   427 NIEEIREAADLLELPQLTQLLSRPQTVMENSSDEPNPHI--CLRIKESMERHCIGDGCFSDVTFE 489
            .:.:|.|..::.:|..:.:.:...:..| |.......|:  ..||||     |:..|.||||||:
Human   432 GLAQIAEVLEMFDLRMMVENIMNKEAFM-NQEITKAFHVRKANRIKE-----CLSKGTFSDVTFK 490

  Fly   490 LDDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQIPPISAVK 554
            ||||.:.||:.:|:..|:.|.||..|.|.|:.::.:..|.:...:...:|.||||.|:.|...:.
Human   491 LDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLD 555

  Fly   555 CLNLLELANRLCLPRLLNLVECRVIEDLTLISQNETNETVD-HCLKLLEPVKLHNAHQLAEWCMS 618
            .|.|:.||||.|||.|:.|.|...:::||..:.:...  :| ..|..||..:.|||||||.||:.
Human   556 PLELIALANRFCLPHLVALAEQHAVQELTKAATSGVG--IDGEVLSYLELAQFHNAHQLAAWCLH 618

  Fly   619 YLCVNYNLICKFSLKGLKALHQDNQEYLREHRWPPVWYLKDYDYYQRCLNELNKE---LKLKTSR 680
            ::|.|||.:|....|.:|:...|||||...||||||||||:.|:|||...|..||   |....||
Human   619 HICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSR 683

  Fly   681 RE 682
            |:
Human   684 RK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	128/202 (63%)
		RHO	16..211	CDD:197554	126/199 (63%)
		BTB	<392..446	CDD:295341	15/56 (27%)
		BTB	481..575	CDD:279045	40/93 (43%)
		BTB	485..582	CDD:197585	38/96 (40%)
RHOBTB1	NP_001229288.1	Rho-like	1..210		134/213 (63%)
		RhoBTB	13..207	CDD:133275	128/202 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..348		2/20 (10%)
		BTB	<396..455	CDD:197585	14/58 (24%)
		BTB	476..581	CDD:306997	44/109 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1326
Isobase	1	0.950	-	0	Normalized mean entropy	S2597
OMA	1	1.010	-	-		QHG49800
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm41543
orthoMCL	1	0.900	-	-		OOG6_105764
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790