DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and RHO5

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_014219.1	Gene:	RHO5 / 855541	SGDID:	S000005124	Length:	331	Species:	Saccharomyces cerevisiae

Alignment Length:	234	Identity:	67/234 - (28%)
Similarity:	100/234 - (42%)	Gaps:	55/234 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQY----RIYKDVLERSWEVVDG 74
            :|||::||.|||||.|:.:...|      ...:.:||||:  |.|    .|.........|:.:|
Yeast     4 IKCVIIGDGAVGKTSLLISYTTN------SFPTDYVPTVF--DNYSTTIAIPNGTASSPLELDNG 60

  Fly    75 VN------------------VSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKM 119
            .:                  ..:.||||.|  |:|:.|...|.::|:.|:|||::...|..|...
Yeast    61 NDKRGSLSSASSSPSTDRKLYKINLWDTAGQEDYDRLRPLCYPQTDIFLICFSVSEHASFANVTE 125

  Fly   120 MWYPEIRRF-----------CPDVPVILVGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVM 173
            .|.||:::.           ....|::|||.|:|||.....:..|.           ...||.|.
Yeast   126 KWLPELKQTSNIEGTSLYTKLGKYPILLVGTKSDLRDDPATQKKLQ-----------EANSDYVS 179

  Fly   174 PDEARAVAKELG-VAYYETSVFTYFGVNEVFENAIRSAL 211
            .:|...:.:..| :.|.|.|..|..||.||||.|:|.|:
Yeast   180 QEEIDELVQRCGFMGYTECSAATQAGVREVFEQAVRYAI 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	66/231 (29%)
		RHO	16..211	CDD:197554	65/230 (28%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
RHO5	NP_014219.1	RHO	6..220	CDD:197554	66/232 (28%)
RHO5	NP_014219.1	PBP1	<161..>316	CDD:227507	20/69 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900