DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and RHO3

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_012148.1	Gene:	RHO3 / 854688	SGDID:	S000001380	Length:	231	Species:	Saccharomyces cerevisiae

Alignment Length:	213	Identity:	67/213 - (31%)
Similarity:	98/213 - (46%)	Gaps:	31/213 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIY-KDVLERSWEVVDGVNVS 78
            |.|::||.|.|||.|           |:.....:.|.|:....:..| .|:.      ||..:::
Yeast    18 KIVILGDGACGKTSL-----------LNVFTRGYFPEVYEPTVFENYIHDIF------VDSKHIT 65

  Fly    79 LRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVILVGCKN 141
            |.||||.|  :.|:.|..:|..:..::|||||.|..||.|.:..|..||...|..|.::||..|.
Yeast    66 LSLWDTAGQEEFDRLRSLSYSDTQCIMLCFSIDSRDSLENVQNKWVGEITDHCEGVKLVLVALKC 130

  Fly   142 DLRYMYRDENYL---------SYFGEKGTFVRAALK-SDLVMPDEARAVAKELG-VAYYETSVFT 195
            |||....:.|.:         |...:.|..:.:... .:|:..:|..|:||::| :.|.|.|...
Yeast   131 DLRNNENESNAITPNNIQQDNSVSNDNGNNINSTSNGKNLISYEEGLAMAKKIGALRYLECSAKL 195

  Fly   196 YFGVNEVFENAIRSALIA 213
            ..||||.|..|.|.||.|
Yeast   196 NKGVNEAFTEAARVALTA 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	64/208 (31%)
		RHO	16..211	CDD:197554	63/208 (30%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
RHO3	NP_012148.1	Rho3	17..231	CDD:206706	67/213 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900