DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and RHO4

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_012981.3	Gene:	RHO4 / 853929	SGDID:	S000001763	Length:	291	Species:	Saccharomyces cerevisiae

Alignment Length:	219	Identity:	72/219 - (32%)
Similarity:	111/219 - (50%)	Gaps:	52/219 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KMDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLST----HVPTVWAIDQYRIYKD 63
            |..|:.|...| |.|:|||.|||||.|:          :|.:..|    ::||::
Yeast    63 KRTNKLPDYHL-KIVVVGDGAVGKTCLL----------ISYVQGTFPTDYIPTIF---------- 106

  Fly    64 VLERSWEVVDGVN---VSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYP 123
              |.....::|.|   :.|.||||.|  ::.:.|..:|..:||:::|:|:.|..||:|.:.:|:|
Yeast   107 --ENYVTNIEGPNGQIIELALWDTAGQEEYSRLRPLSYTNADVLMVCYSVGSKTSLKNVEDLWFP 169

  Fly   124 EIRRFCPDVPVILVGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGV-A 187
            |::.|||..|::|||.|:||   |..:|.                ||||.|..|.::||.||. |
Yeast   170 EVKHFCPSTPIMLVGLKSDL---YEADNL----------------SDLVEPSSAESLAKRLGAFA 215

  Fly   188 YYETSVFTYFGVNEVFENAIRSAL 211
            :.:.|......::||||.||.:.|
Yeast   216 HIQCSARLKENIDEVFETAIHTLL 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	68/207 (33%)
		RHO	16..211	CDD:197554	66/204 (32%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
RHO4	NP_012981.3	Rho4_like	70..248	CDD:206704	69/212 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900