Protein Alignment RhoBTB and Rhobtb3

DIOPT Version :9

• Sequence 1: NP_001262107.1
• Gene: RhoBTB / 40249
• FlyBaseID: FBgn0036980
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_082769.1
• Gene: Rhobtb3 / 73296
• MGIID: 1920546
• Length: 611
• Species: Mus musculus
• Alignment Length: 636
• Identity: 145/636 - (22%)
• Similarity: 239/636 - (37%)
• Gaps: 150/636 - (23%)

  Fly    81 LWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVIL--VG----- 138
            :||.|.......|...|.:|::::.:::....|....|..:.|.|:|....||||:  ||
Mouse    75 VWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNE 139

  Fly   139 --------CKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSVFT 195
                    |.:|                         :...|...|...:|||||..|.|.....
Mouse   140 ELPCTCPLCTSD-------------------------RGSCVTTTEGIQLAKELGATYLELHSLD 179

  Fly   196 YFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPF---RPPKPPPPE----VTVMVGNY 253
            .|.:.:.|...:...:|....|:    ..:|::|..:.:.|   |||:...||    :.....:|
Mouse   180 DFYIGKYFGGVLEYFMIQALNQK----TSEKMKKRKMTSSFHGIRPPQLEQPEKMPVLKAEASHY 240

  Fly   254 RQDIYNMFLSQAYTDLVLVGAGGTKFA-VHRFMLAAASSIFQRLLSTELTDMGGRSSSESSMVSS 317
            ..|:.|:.|.....|:|......|... .|:.:|.:.|.:|..|
Mouse   241 HSDLNNLLLCCQCVDVVFYHPEVTGVVEAHKIVLCSVSHVFMLL--------------------- 284

  Fly   318 TFGEATIADFNDDTEALIRYESRTQRMWEHLKRRSSYQALPLMESKRSNDLYRELHHPVLQSIRL 382
             |...:.||..|  .::||                           .:.||:......||.....
Mouse   285 -FNVKSPADIQD--SSIIR---------------------------TTQDLFAINRDAVLPGASQ 319

  Fly   383 VHVENHRGVNGLQTIVTLSKLISPQALHQCLRFIYTGTIDKDCDNIEE-----IREAADLLELPQ 442
            ....|    ..|..||..:...|  .|...|||||:|..  ..:.:||     ::::.|
Mouse   320 EAPSN----PPLPVIVKDALFCS--CLSDILRFIYSGAF--QWEELEEDVRRKLKDSGD------ 370

  Fly   443 LTQLLSRPQTVMENSSDEPNPHICLRIKESME------------RHCIGDGCFSDVTFELDDGLM 495
            ::.::.:.:.:::.    |....|||..::.:            :..:.....:||.||:....:
Mouse   371 VSDIIEKVKCILKT----PGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATV 431

  Fly   496 KAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQIPPISAVKCLNLLE 560
            .||||:||.||:||.||..|::.||.|.:|...||:..||...|.|||||...|....:.:.||.
Mouse   432 PAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLI 496

  Fly   561 LANRLCLPRLLNLVECRVIEDLTLISQNETNETVDHCLKLLEPVKLHNAHQLAEWCMSYLCVNYN 625
            .|....:.||.::.|..:|..|..:...|........:.||:..|.|::..|:.|.:.::..||.
Mouse   497 CAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYL 561

  Fly   626 LICKFSLK-GLKALHQDNQEYLREHRWPPVWYLKDYDYYQ--------RCL 667
            :   ||.| ..:.|..:.:.::.:||||...|||....|:        |||
Mouse   562 I---FSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCL 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	30/143 (21%)
		RHO	16..211	CDD:197554	30/144 (21%)
		BTB	<392..446	CDD:295341	14/58 (24%)
		BTB	481..575	CDD:279045	37/93 (40%)
		BTB	485..582	CDD:197585	39/96 (41%)
Rhobtb3	NP_082769.1	Rho-like	1..175		27/124 (22%)
		P-loop_NTPase	34..174	CDD:304359	27/123 (22%)
		BTB	413..515	CDD:279045	38/101 (38%)
		Interaction with Rab9. /evidence=ECO:0000250	420..611		64/193 (33%)
		BTB	421..518	CDD:197585	39/96 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810