DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and RHOJ

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_065714.1	Gene:	RHOJ / 57381	HGNCID:	688	Length:	214	Species:	Homo sapiens

Alignment Length:	219	Identity:	67/219 - (30%)
Similarity:	105/219 - (47%)	Gaps:	46/219 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDGV 75
            ::::|||:|||.|||||.|:.:.|.:      .....:||||:  |.|.:        ...|.|.
Human    19 KKMLKCVVVGDGAVGKTCLLMSYAND------AFPEEYVPTVF--DHYAV--------TVTVGGK 67

  Fly    76 NVSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVILVG 138
            ...|.|:||.|  |:::.|..:|..:||.|:|||:.:|.|..|.:..|.||::...|.||.:|:|
Human    68 QHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELKDCMPHVPYVLIG 132

  Fly   139 CKNDL--------RYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGV-AYYETSVF 194
            .:.||        |.:|..|..|:|  |.|.                 .:||.:|. .|.|.|..
Human   133 TQIDLRDDPKTLARLLYMKEKPLTY--EHGV-----------------KLAKAIGAQCYLECSAL 178

  Fly   195 TYFGVNEVFENAIRSALIARRQQR 218
            |..|:..||:.||.:....:::::
Human   179 TQKGLKAVFDEAILTIFHPKKKKK 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	67/208 (32%)
		RHO	16..211	CDD:197554	66/205 (32%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
RHOJ	NP_065714.1	P-loop_NTPase	22..195	CDD:422963	67/207 (32%)
RHOJ	NP_065714.1	Effector region. /evidence=ECO:0000255	50..58		5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900