DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and rhof

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001018478.1	Gene:	rhof / 573655	ZFINID:	ZDB-GENE-050522-280	Length:	209	Species:	Danio rerio

Alignment Length:	219	Identity:	69/219 - (31%)
Similarity:	104/219 - (47%)	Gaps:	44/219 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDG 74
            |.:.:|.|:|||...|||.|:...|      .......:.|:|:  |:|     |...|:   .|
Zfish    13 HADALKIVIVGDGGCGKTSLLMVYA------KGDFPEKYAPSVF--DKY-----VTTVSY---GG 61

  Fly    75 VNVSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVILV 137
            .::.|.|:||.|  |:|:.|..:|...::||:|:.:.:|.|..|.|:.||||:|.||.|.|:||:
Zfish    62 KDIQLNLYDTAGQEDYDRLRPLSYQDVNIVLICYDVTNPTSFDNVKIKWYPEVRHFCRDAPIILI 126

  Fly   138 GCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEA-------RAVAKELGV-AYYETSVF 194
            .||.|||   :|:       ||...::|.        |:|       ....||:.. .|.|.|..
Zfish   127 SCKTDLR---KDK-------EKMRRLKAL--------DQAPITYLLGEQTQKEMNAEIYLECSAK 173

  Fly   195 TYFGVNEVFENAIRSALIARRQQR 218
            ....|.::|..|.:.||.||.:.|
Zfish   174 YRENVEDIFREATKRALAARAKAR 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	63/207 (30%)
		RHO	16..211	CDD:197554	62/204 (30%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
rhof	NP_001018478.1	P-loop_NTPase	17..209	CDD:304359	68/215 (32%)
rhof	NP_001018478.1	RHO	19..186	CDD:197554	61/200 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900