DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and rhobtb2b

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_017213602.2	Gene:	rhobtb2b / 565844	ZFINID:	ZDB-GENE-071125-1	Length:	722	Species:	Danio rerio

Alignment Length:	735	Identity:	295/735 - (40%)
Similarity:	413/735 - (56%)	Gaps:	107/735 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
Zfish    16 MDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERS 80

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|:||||||||||||.|||||||||||||:||||||:|.||.:.|.||||||:.|||..|
Zfish    81 RDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLFHVKTMWYPEIKHFCPRAP 145

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            ||||||:.||||     :.|....|:         |....::::.|::.|.|||||.|.||||||
Zfish   146 VILVGCQLDLRYADLEAVNRARRPLA---------RPIKANEILPPEKGREVAKELCVPYYETSV 201

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTVMVGNYRQDIY 258
            ...|||.:||:||||:|||:||..:||.::|:.||:|||||||.|||||||.:||.......|.:
Zfish   202 VAQFGVKDVFDNAIRAALISRRHLQFWKSHLRDVQRPLLQAPFLPPKPPPPVITVPPAPSPTDEH 266

  Fly   259 --NMFLSQAYTDLVLVGAGGTKFAVHRFMLAAASSIFQRLLSTELTDMGGR-------------S 308
              .:.......|::||.....:...|:..||.|||.|..|...:  .:.||             |
Zfish   267 PGRLLEEPLCADVLLVLQEHHRVFAHKVYLATASSKFYDLFVQD--SVLGRESPAQADSFDIENS 329

  Fly   309 SSESSMVSSTFGE-------ATIADFNDDTEALI------RYESRTQRMWEHLKRRSSYQALPLM 360
            :|....||.:..|       |.|:|.....:|.:      |..|...|.:..::|.|....:.|
Zfish   330 TSHQHPVSESIDEDSTVKMRACISDGTLTNDAPLEMSHGGRLSSALGRAFISMRRESVQDPVTL- 393

  Fly   361 ESKRSNDLYRELHHPVLQSIRLVHVENHRGVNGLQTIVTLSKLISPQALHQCLRFIYTGTIDKDC 425
                           |.:.:.:||::.             |.|..|.|:  .||::|||.:|::.
Zfish   394 ---------------VSRPMTVVHLDP-------------SVLFGPFAV--VLRYLYTGRLDENE 428

  Fly   426 DNIEEIREAADLLELPQLTQLLSRPQTVMENSSDEPNPHICL--------RIKESMERHCIGDGC 482
            .::..|...|:|||:..|..:::.    :.|:....|..|..        |:||     |:..|.
Zfish   429 KDLMHIAHIAELLEVFDLRMMVAN----ILNNEAFMNQEITKAFHVRRTNRVKE-----CLAKGT 484

  Fly   483 FSDVTFELDDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQI 547
            ||||.|:||||.::||:.:|:..||.|.||..|.|.|:.:..::||..:..:...:|.||||.:.
Zfish   485 FSDVVFQLDDGTVEAHKPLLISSCDWMAAMFGGPFVESSTKEVLFPNTSRSSMQAVLEYLYTGRF 549

  Fly   548 PPISAVKCLNLLELANRLCLPRLLNLVECRVIEDLTLISQNETNET-VD-HCLKLLEPVKLHNAH 610
            .....:..:.|:.||||||||.|:.|.|   :..:|::.::....| :| ..|..||..:.|.|.
Zfish   550 CSRPDLDTMELIILANRLCLPHLVALTE---LHTVTVLKESAAAGTDIDGDVLLYLEMAQFHCAE 611

  Fly   611 QLAEWCMSYLCVNYNLICKFSLKGLKALHQDNQEYLREHRWPPVWYLKDYDYYQRCLNELNKE-- 673
            ||..||:.::|.|||.:|:...:.::|...:||||..:.||||||:||:.|:|||.|.|..:|
Zfish   612 QLTSWCLHHICTNYNNVCRKFPRDMRAKSAENQEYFEKQRWPPVWFLKEDDHYQRALKERQQEDS 676

  Fly   674 --LKLKTSRR------ESPS 685
              ||.::.||      :||:
Zfish   677 LNLKRQSRRRWTLRSIQSPA 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	127/202 (63%)
		RHO	16..211	CDD:197554	125/199 (63%)
		BTB	<392..446	CDD:295341	16/53 (30%)
		BTB	481..575	CDD:279045	39/93 (42%)
		BTB	485..582	CDD:197585	37/96 (39%)
rhobtb2b	XP_017213602.2	RhoBTB	24..218	CDD:133275	127/202 (63%)
		BTB	270..>310	CDD:321966	11/39 (28%)
		BTB	<412..456	CDD:333434	13/49 (27%)
		BTB	487..579	CDD:197585	37/94 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2058
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22873
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1354
OMA	1	1.010	-	-		QHG49800
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm24496
orthoMCL	1	0.900	-	-		OOG6_105764
Panther	1	1.100	-	-	LDO	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.840