DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and Cdc42

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001245762.1	Gene:	Cdc42 / 32981	FlyBaseID:	FBgn0010341	Length:	191	Species:	Drosophila melanogaster

Alignment Length:	204	Identity:	76/204 - (37%)
Similarity:	105/204 - (51%)	Gaps:	32/204 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDGVN 76
            :.:|||:|||.|||||.|:.:...||      ..|.:||||:  |.|.:        ..::.|..
  Fly     2 QTIKCVVVGDGAVGKTCLLISYTTNK------FPSEYVPTVF--DNYAV--------TVMIGGEP 50

  Fly    77 VSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVILVGC 139
            .:|.|:||.|  |:|:.|..:|.::||.|:|||:.||.|..|.|..|.|||...|...|.:|||.
  Fly    51 YTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGT 115

  Fly   140 KNDLRYMYRDENYLSYFGEKGTFVRAAL-KSDLVMPDEARAVAKEL-GVAYYETSVFTYFGVNEV 202
            :.||    ||||        .|..:.|. |...:..::...:|||| .|.|.|.|..|..|:..|
  Fly   116 QIDL----RDEN--------STLEKLAKNKQKPITMEQGEKLAKELKAVKYVECSALTQKGLKNV 168

  Fly   203 FENAIRSAL 211
            |:.||.:||
  Fly   169 FDEAILAAL 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	74/201 (37%)
		RHO	16..211	CDD:197554	73/198 (37%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
Cdc42	NP_001245762.1	Cdc42	3..177	CDD:206664	74/201 (37%)
Cdc42	NP_001245762.1	RHO	6..179	CDD:197554	75/200 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840