DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and Rhobtb1

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001101092.1	Gene:	Rhobtb1 / 309722	RGDID:	1306871	Length:	695	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	299/716 - (41%)
Similarity:	399/716 - (55%)	Gaps:	73/716 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
  Rat     5 MDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERS 69

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|::|||||||||||.|||||||||||||:||||||:|.||.:.|.|||.||:.|||..|
  Rat    70 RDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTP 134

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            |:||||:.||||     :.|....|:         |...:.|::.|::.|.||||||:.||||||
  Rat   135 VVLVGCQLDLRYADLEAVNRARRPLA---------RPIKRGDILPPEKGREVAKELGIPYYETSV 190

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTV----MVGNYR 254
            |..||:.:||:||||:|||:||..:||.::|||||||||||||.|||.|||.:.|    ..|.
  Rat   191 FDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGT-- 253

  Fly   255 QDIYNMFLSQAYTDLVLVGAGGTKFAVHRFMLAAASSIFQRLLSTELTDMGGRSSSESSMVSSTF 319
            .|...:..:....|::.:.........||..||.:||.|..|...|..|..|.|.....
  Rat   254 SDAACLLDNPLCADVLFILHDQEHIFAHRIYLATSSSKFYDLFLMECEDSPGWSGGAGE------ 312

  Fly   320 GEATIADFNDDTEALIRYESRTQRMWEHLKRRSSYQALPLMESKRSN--DLYRELHHPVLQSIRL 382
             |....||          :.|||.:....:.:...|..|..:...|:  ||...|......|:..
  Rat   313 -EVPCRDF----------QGRTQSLGAAEEGQEGSQRTPQADPGASSGQDLLESLASQTDASVSE 366

  Fly   383 VH---------VENHRGVN--------GLQTIVTLSKLISPQALHQCLRFIYTGTID---KDCDN 427
            .|         |..||.|.        |..|:|.|...:........|||:|:|.:|   ||...
  Rat   367 AHALTGWSKGFVSMHREVRVNPISKRVGPVTVVRLDSSMQSGPFRTLLRFLYSGQLDEKEKDLLG 431

  Fly   428 IEEIREAADLLELPQLTQLLSRPQTVMENSSDEPNPHI--CLRIKESMERHCIGDGCFSDVTFEL 490
            :.::.|..::.:|..:.:.:...:..| |.......|:  ..||||     |:..|.||||||.|
  Rat   432 LAQMAEVLEMFDLRMMVENIMNKEAFM-NQEITKAFHVRKANRIKE-----CLSKGTFSDVTFTL 490

  Fly   491 DDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQIPPISAVKC 555
            |||.:.||:.:|:..|:.|.||..|.|.|:.::.:..|.:...:...:|.||||.|:.|...:..
  Rat   491 DDGAISAHKPLLICSCEWMAAMFGGSFVESTNSEVHLPNINKMSMQAVLEYLYTKQLSPNLDLDP 555

  Fly   556 LNLLELANRLCLPRLLNLVECRVIEDLTLISQNETNETVD-HCLKLLEPVKLHNAHQLAEWCMSY 619
            |.|:.||||.||..|:.|||...:::||..:  .:..::| ..|..||..:.|||:|||.||:.:
  Rat   556 LELIALANRFCLTHLVALVEQHAVQELTKAA--VSGVSIDGEVLSYLELAQFHNANQLAAWCLHH 618

  Fly   620 LCVNYNLICKFSLKGLKALHQDNQEYLREHRWPPVWYLKDYDYYQRCLNELNKE---LKLKTSRR 681
            :|.|||.:|....|.:|:...|||||...||||||||||:.|:|||...|..||   |....|||
  Rat   619 ICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRR 683

  Fly   682 E 682
            :
  Rat   684 K 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	125/202 (62%)
		RHO	16..211	CDD:197554	123/199 (62%)
		BTB	<392..446	CDD:295341	14/64 (22%)
		BTB	481..575	CDD:279045	39/93 (42%)
		BTB	485..582	CDD:197585	38/96 (40%)
Rhobtb1	NP_001101092.1	RhoBTB	13..207	CDD:133275	125/202 (62%)
		BTB_POZ	248..459	CDD:365784	48/230 (21%)
		BTB_POZ	464..589	CDD:365784	49/131 (37%)
		BACK_RHOBTB1	592..691	CDD:350605	45/93 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I1999
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1276
OMA	1	1.010	-	-		QHG49800
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm45666
orthoMCL	1	0.900	-	-		OOG6_105764
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880