DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and RHOD

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_055393.1	Gene:	RHOD / 29984	HGNCID:	670	Length:	210	Species:	Homo sapiens

Alignment Length:	215	Identity:	73/215 - (33%)
Similarity:	104/215 - (48%)	Gaps:	31/215 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVD 73
            |....||.|||||...|||.|:...|.      .....::.|||:  ::|.:...        |.
Human    13 PGVRSVKVVLVGDGGCGKTSLLMVFAD------GAFPESYTPTVF--ERYMVNLQ--------VK 61

  Fly    74 GVNVSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVIL 136
            |..|.|.:|||.|  |:|:.|...|..:.|:||||.:.||.|..|....||||:..||..||:|:
Human    62 GKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIV 126

  Fly   137 VGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELG-VAYYETSVFTYFGVN 200
            ||||.|||   :|::.::.....|.        :.|.....:.:|:.:| |||.|.|...:..|:
Human   127 VGCKTDLR---KDKSLVNKLRRNGL--------EPVTYHRGQEMARSVGAVAYLECSARLHDNVH 180

  Fly   201 EVFENAIRSALIARRQQRFW 220
            .||:.|...|| :.|.:.||
Human   181 AVFQEAAEVAL-SSRGRNFW 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	67/200 (34%)
		RHO	16..211	CDD:197554	65/197 (33%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
RHOD	NP_055393.1	Rho4_like	16..210	CDD:206704	72/212 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900