Protein Alignment RhoBTB and RND1

DIOPT Version :10

• Sequence 1: NP_001262107.1
• Gene: RhoBTB / 40249
• FlyBaseID: FBgn0036980
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_055285.1
• Gene: RND1 / 27289
• HGNCID: 18314
• Length: 232
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 76/245 - (31%)
• Similarity: 105/245 - (42%)
• Gaps: 54/245 - (22%)

  Fly     8 QPHQELVKCVLVGDTAVGKTRL--ICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWE 70
            ||.....|.|||||...|||.:  :.|:.|..        .|:||||     :..|...||
Human     8 QPVVARCKLVLVGDVQCGKTAMLQVLAKDCYP--------ETYVPTV-----FENYTACLE---- 55

  Fly    71 VVDGVNVSLRLWDTFGD--HDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
             .:...|.|.||||.|.  :|..|...|..||.|||||.|:.|.::.:....|..||..:||...
Human    56 -TEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTR 119

  Fly   134 VILVGCKNDLR--------YMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGV-AYY 189
            |:|:|||.|||        ..::.:..:||  |:|.                 |:||:||. .|.
Human   120 VLLIGCKTDLRTDLSTLMELSHQKQAPISY--EQGC-----------------AIAKQLGAEIYL 165

  Fly   190 ETSVFT-YFGVNEVFENAIRSALIARRQQRF-WMTNLKKVQKPLLQAPFR 237
            |.|.|| ...::.:|..|  |.|...:.... ..:.::.:.|.||..|.|
Human   166 EGSAFTSEKSIHSIFRTA--SMLCLNKPSPLPQKSPVRSLSKRLLHLPSR 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	67/211 (32%)
		BTB1_POZ_RhoBTB	255..452	CDD:349608
		BTB2_POZ_RhoBTB	475..582	CDD:349609
		BACK_RHOBTB	593..669	CDD:350574
RND1	NP_055285.1	Rnd1_Rho6	1..232	CDD:206737	76/245 (31%)
		Effector region. /evidence=ECO:0000255	42..50		4/12 (33%)