DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and Rhobtb2

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_036014493.1	Gene:	Rhobtb2 / 246710	MGIID:	2180557	Length:	750	Species:	Mus musculus

Alignment Length:	808	Identity:	300/808 - (37%)
Similarity:	417/808 - (51%)	Gaps:	172/808 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
Mouse    27 MDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERS 91

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|:||||||||||||.|||||||||||||:||||||:|.||.:.|.||||||:.|||..|
Mouse    92 RDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAP 156

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            ||||||:.||||     :.|....|:         |....::::.|::.|.||||||:.||||||
Mouse   157 VILVGCQLDLRYADLEAVNRARRPLA---------RPIKPNEILPPEKGREVAKELGIPYYETSV 212

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTV---------- 248
            ...||:.:||:||||:|||:||..:||.::|:.||:|||||||.|||||||.:.|
Mouse   213 VAQFGIKDVFDNAIRAALISRRHLQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEEC 277

  Fly   249 -------------------MVGNYRQDIYNMFLSQAYTDLVLV-----------GAGGTKFAVHR 283
                               .|..:...||....|..:.||.|:           |:||.:...||
Mouse   278 PAHLLEDPLCADVILVLQERVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSGSGGPRPEDHR 342

  Fly   284 -----------------FMLAAASSIFQRLLSTELTDMGGRSSSESSMVSSTFGEATIADFNDDT 331
                             |:|.|||  |.  :...:.:.||  |..:.:.:||            :
Mouse   343 SHPEQHHHHHHHHHGRDFLLRAAS--FD--VCESVDEAGG--SGPAGLRAST------------S 389

  Fly   332 EALIR-----Y---ESRTQRMWEHLKRRSSYQALPLMESKRSNDLYRELHHPVLQSIRLVHVENH 388
            :.::|     |   ..|....|.        :|...::.:.:.|       |:....||:
Mouse   390 DGILRGNGTGYLPGRGRVLSSWS--------RAFVSIQEEMAED-------PLTFKSRLM----- 434

  Fly   389 RGVNGLQTIVTLSKLISPQALHQCLRFIYTGTIDKDCDNIEEIREAADLLELPQLTQLLSRPQTV 453
                   .:|.:...|.|......|:::|||.:.::..::..|...|:|||:..|..:::.
Mouse   435 -------VVVKMDNSIQPGPFRAVLKYLYTGELGENERDLMHIAHIAELLEVFDLRMMVAN---- 488

  Fly   454 MENSSDEPNPHICL--------RIKESMERHCIGDGCFSDVTFELDDGLMKAHRAVLVGRCDVMR 510
            :.|:....|..|..        |:||     |:..|.||||||.||||.:.||:.:|:..||.|.
Mouse   489 ILNNEAFMNQEITKAFHVRRTNRVKE-----CLAKGTFSDVTFILDDGTISAHKPLLISSCDWMA 548

  Fly   511 AMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQIPPISAVKCLNLLELANRLCLPRLLNLVE 575
            ||..|.|.|:.:..:|||..:......:|.||||........:..:.|:.||||||||.|:.|.|
Mouse   549 AMFGGPFVESSTREVVFPYTSKSCMRAVLEYLYTGMFTSSPDLDDMKLIVLANRLCLPHLVALTE 613

  Fly   576 CRVIEDLTLISQNETNETVD---HCLKLLEPVKLHNAHQLAEWCMSYLCVNYNLICKFSLKGLKA 637
            ...:..|    ...|...||   ..|..||..:.|.|:|||:||:.::|.|||.:|:...:.:||
Mouse   614 QYTVTGL----MEATQMMVDIDGDVLVFLELAQFHCAYQLADWCLHHICTNYNNVCRKFPRDMKA 674

  Fly   638 LHQDNQEYLREHRWPPVWYLKDYDYYQRCLNELNKE----LKLKTSRRESPSDDEGCLCFTGVFS 698
            :..:||||..:||||||||||:.|:|||...|..||    |:.:..||
Mouse   675 MSPENQEYFEKHRWPPVWYLKEEDHYQRARKEREKEDYLHLRRQPKRR----------------- 722

  Fly   699 CWLL--GKSKRSADVSGTTDNSNADNQI 724
             ||.  ..|..|:..:|:...|::.:.:
Mouse   723 -WLFWNSPSSPSSSAAGSASPSSSSSAV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	126/202 (62%)
		RHO	16..211	CDD:197554	124/199 (62%)
		BTB	<392..446	CDD:295341	13/53 (25%)
		BTB	481..575	CDD:279045	41/93 (44%)
		BTB	485..582	CDD:197585	39/96 (41%)
Rhobtb2	XP_036014493.1	RhoBTB	35..229	CDD:133275	126/202 (62%)
		BTB_POZ	272..497	CDD:365784	46/273 (17%)
		BTB2_POZ_RHOBTB2	502..625	CDD:349668	47/131 (36%)
		BACK_RHOBTB2	630..726	CDD:350606	43/113 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2066
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22873
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1313
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49800
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm43593
orthoMCL	1	0.900	-	-		OOG6_105764
Panther	1	1.100	-	-	LDO	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840