DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and RHOQ

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_036381.2	Gene:	RHOQ / 23433	HGNCID:	17736	Length:	205	Species:	Homo sapiens

Alignment Length:	210	Identity:	69/210 - (32%)
Similarity:	108/210 - (51%)	Gaps:	30/210 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVD 73
            |...::|||:|||.|||||.|:.:.|.:      .....:||||:  |.|.:.        ..|.
Human     5 PGALMLKCVVVGDGAVGKTCLLMSYAND------AFPEEYVPTVF--DHYAVS--------VTVG 53

  Fly    74 GVNVSLRLWDTFG--DHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVPVIL 136
            |....|.|:||.|  |:|:.|..:|..:||.|:|||:.:|.|.:|.|..|.||::.:.|:||.:|
Human    54 GKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLL 118

  Fly   137 VGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGV-AYYETSVFTYFGVN 200
            :|.:.|||   .|...|:...:        :|...:..::.:.:|||:|. .|.|.|..|..|:.
Human   119 IGTQIDLR---DDPKTLARLND--------MKEKPICVEQGQKLAKEIGACCYVECSALTQKGLK 172

  Fly   201 EVFENAIRSALIARR 215
            .||:.||.:.|..::
Human   173 TVFDEAIIAILTPKK 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	67/200 (34%)
		RHO	16..211	CDD:197554	66/197 (34%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
RHOQ	NP_036381.2	Tc10	10..183	CDD:206707	67/199 (34%)
RHOQ	NP_036381.2	Effector region. /evidence=ECO:0000250	38..46		5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810