DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and RHOBTB2

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001153508.1	Gene:	RHOBTB2 / 23221	HGNCID:	18756	Length:	749	Species:	Homo sapiens

Alignment Length:	782	Identity:	295/782 - (37%)
Similarity:	411/782 - (52%)	Gaps:	134/782 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
Human    27 MDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERS 91

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|:||||||||||||.|||||||||||||:||||||:|.||.:.|.||||||:.|||..|
Human    92 RDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAP 156

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            ||||||:.||||     :.|....|:         |....::::.|::.|.||||||:.||||||
Human   157 VILVGCQLDLRYADLEAVNRARRPLA---------RPIKPNEILPPEKGREVAKELGIPYYETSV 212

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTV--MVGNYRQD 256
            ...||:.:||:||||:|||:||..:||.::|:.||:|||||||.|||||||.:.|  ...:..:.
Human   213 VAQFGIKDVFDNAIRAALISRRHLQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEEC 277

  Fly   257 IYNMFLSQAYTDLVLVGAGGTKFAVHRFMLAAASSIFQRLLSTELT--DMGGRSSSESSMVSSTF 319
            ..::.......|::||.....:...|:..|:.:||.|..|...:|:  ::||.|....:......
Human   278 PAHLLEDPLCADVILVLQERVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQ 342

  Fly   320 GEA-----------------TIADFN------------------DDTEALIR-----Y---ESRT 341
            |.:                 ..|.|:                  ..::.::|     |   ..|.
Human   343 GHSDQHHHHHHHHHGRDFLLRAASFDVCESVDEAGGSGPAGLRASTSDGILRGNGTGYLPGRGRV 407

  Fly   342 QRMWEHLKRRSSYQALPLMESKRSNDLYRELHHPVLQSIRLVHVENHRGVNGLQTIVTLSKLISP 406
            ...|.        :|...::.:.:.|       |:....||:            .:|.:...|.|
Human   408 LSSWS--------RAFVSIQEEMAED-------PLTYKSRLM------------VVVKMDSSIQP 445

  Fly   407 QALHQCLRFIYTGTIDKDCDNIEEIREAADLLELPQLTQLLSRPQTVMENSSDEPNPHICL---- 467
            ......|:::|||.:|::..::..|...|:|||:..|..:::.    :.|:....|..|..
Human   446 GPFRAVLKYLYTGELDENERDLMHIAHIAELLEVFDLRMMVAN----ILNNEAFMNQEITKAFHV 506

  Fly   468 ----RIKESMERHCIGDGCFSDVTFELDDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFP 528
                |:||     |:..|.||||||.||||.:.||:.:|:..||.|.||..|.|.|:.:..:|||
Human   507 RRTNRVKE-----CLAKGTFSDVTFILDDGTISAHKPLLISSCDWMAAMFGGPFVESSTREVVFP 566

  Fly   529 GVTIYTFHKLLCYLYTDQIPPISAVKCLNLLELANRLCLPRLLNLVECRVIEDLTLISQNETNET 593
            ..:......:|.||||........:..:.|:.||||||||.|:.|.|...:..|    ...|...
Human   567 YTSKSCMRAVLEYLYTGMFTSSPDLDDMKLIILANRLCLPHLVALTEQYTVTGL----MEATQMM 627

  Fly   594 VD---HCLKLLEPVKLHNAHQLAEWCMSYLCVNYNLICKFSLKGLKALHQDNQEYLREHRWPPVW 655
            ||   ..|..||..:.|.|:|||:||:.::|.|||.:|:...:.:||:..:||||..:|||||||
Human   628 VDIDGDVLVFLELAQFHCAYQLADWCLHHICTNYNNVCRKFPRDMKAMSPENQEYFEKHRWPPVW 692

  Fly   656 YLKDYDYYQRCLNELNKE----LKLKTSRRESPSDDEGCLCFTGVFSCWLLGKSKRSADVSGTTD 716
            |||:.|:|||...|..||    ||.:..||                  ||...|..|...|..:.
Human   693 YLKEEDHYQRARKEREKEDYLHLKRQPKRR------------------WLFWNSPSSPSSSAASS 739

  Fly   717 NS 718
            :|
Human   740 SS 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	126/202 (62%)
		RHO	16..211	CDD:197554	124/199 (62%)
		BTB	<392..446	CDD:295341	14/53 (26%)
		BTB	481..575	CDD:279045	41/93 (44%)
		BTB	485..582	CDD:197585	39/96 (41%)
RHOBTB2	NP_001153508.1	RhoBTB	35..229	CDD:133275	126/202 (62%)
		RHO	39..230	CDD:197554	124/199 (62%)
		BTB	280..>327	CDD:295341	10/46 (22%)
		BTB	<443..492	CDD:197585	13/52 (25%)
		BTB	<443..490	CDD:295341	13/50 (26%)
		BTB	513..615	CDD:279045	45/106 (42%)
		BTB	523..615	CDD:197585	39/91 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22873
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1326
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49800
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm41543
orthoMCL	1	0.900	-	-		OOG6_105764
Panther	1	1.100	-	-	LDO	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840