DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoBTB and crp-1

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_505688.1	Gene:	crp-1 / 179462	WormBaseID:	WBGene00012532	Length:	187	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	65/215 - (30%)
Similarity:	104/215 - (48%)	Gaps:	51/215 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTV---WAIDQYRIYKDVL 65
            |:|:      :|.|:||||..|||.|:.|      .:..|.|..:..||   ||:..:
Worm     1 MENK------LKLVVVGDTYTGKTSLLVA------YTKKQFLDNYTTTVFDNWAVSVH------- 46

  Fly    66 ERSWEVVDGVNVSLRLWDTF--GDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRF 128
                  :|..|.::.|:||.  |::::.|..:|..::|.|:|||:....:|.:|:..|.||||::
Worm    47 ------IDNKNYAVNLFDTAGQGNYEQIRCLSYPHANVFLVCFSMIDRKTLESCRSTWIPEIRKY 105

  Fly   129 CPD-VPVILVGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGV-AYYET 191
            ..| ||::|||.||||                   |..|...:.|..|.|:.||.|:|. .:|..
Worm   106 AGDNVPIMLVGTKNDL-------------------VDDADSRNTVTEDYAKRVAHEIGCHKFYSC 151

  Fly   192 SVFTYFGVNEVFENAIRSAL 211
            |..|:.|:..||:.:..:|:
Worm   152 SALTHKGLKRVFDESFLAAV 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	62/204 (30%)
		RHO	16..211	CDD:197554	61/201 (30%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
crp-1	NP_505688.1	Rho	5..169	CDD:206641	62/201 (31%)
crp-1	NP_505688.1	RHO	7..171	CDD:197554	61/201 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900