DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and rhobtb1

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_003199615.1	Gene:	rhobtb1 / 100537290	ZFINID:	ZDB-GENE-130530-871	Length:	687	Species:	Danio rerio

Alignment Length:	716	Identity:	293/716 - (40%)
Similarity:	403/716 - (56%)	Gaps:	79/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
Zfish     1 MDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERS 65

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|:||||||||||||.|||||||||||||:||||||:|.||.:.|.|||.||:.|||..|
Zfish    66 RDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYLEIKHFCPRTP 130

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            ||||||:.||||     :.|....||         |.....|::.|:..|.||||||:.||||||
Zfish   131 VILVGCQLDLRYADLEAVNRARRPLS---------RPIKPGDILPPESGREVAKELGIPYYETSV 186

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTV--MVGNYRQD 256
            |..||:.::|:||||:|||:||..:||.::|::||||||||||.|||.|||.:.:  .....|..
Zfish   187 FDQFGIKDIFDNAIRAALISRRHLQFWKSHLRRVQKPLLQAPFLPPKAPPPLIKIPECPAKNRDG 251

  Fly   257 IYNMFLSQAYTDLVLVGAGGTKFAVHRFMLAAASSIFQRLLSTELTDMGGRSSSESSMVSSTFGE 321
            ...:..:....|::.:.........||..|:.:||.|..|..
Zfish   252 PKQLLETPLCADVMFIVQEHVHLYAHRIYLSTSSSKFFDLFQ----------------------- 293

  Fly   322 ATIADFNDDTEALIRYE--SRTQRMWE-HLKRRSSYQALP------LMESKRSNDL----YRELH 373
               .||:|:::.|:..|  .|.|.|.. .|........||      |..||....|    :..:|
Zfish   294 ---MDFSDESQCLVVTERHGRDQLMRTLSLDTEEDVMVLPNLSPCSLRASKSDGTLKMMSFSGMH 355

  Fly   374 HPVLQSIR-------LVHVEN----HRGVNGLQTIVTLSKLISPQALHQCLRFIYTGTIDKDCDN 427
            .....|:.       .:|.||    ..|...|.|||.:...|........|||:|||.:|:...:
Zfish   356 RRTRLSLASWSKAFYSIHKENVINPVTGTPALMTIVKMDHSIHHGPFSAVLRFLYTGELDEKEKD 420

  Fly   428 IEEIREAADLLELPQLTQLLSRPQTVMENS---SDEPNPHICLRIKESMERHCIGDGCFSDVTFE 489
            :.:|.:.|::||:..|..::   :.:|.|.   :.|......:| |.:..:.|:....|:||.|.
Zfish   421 LMKIAQIAEILEVFDLRMMV---ENIMNNEGFMNQEITKAFHVR-KANRIKECLAKNNFTDVVFR 481

  Fly   490 LDDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQIPPISAVK 554
            ||||.:.||:.:|:..||.|.|:..|.|.|:.::.:.||..:......:|.||||:|:.|::.:.
Zfish   482 LDDGTINAHKPLLISSCDWMAALFGGSFMESANDEVSFPNTSRVCMQAVLEYLYTNQLSPMADLD 546

  Fly   555 CLNLLELANRLCLPRLLNLVECRVIEDLTLISQNETNETVD-HCLKLLEPVKLHNAHQLAEWCMS 618
            .:.|:.||||||||||:.|.|...:.:  |:..::..:.:| ..|..||..:.|||:|||.||:.
Zfish   547 PMELIALANRLCLPRLIALTEQYAVSE--LLKASKDGQDIDGEVLTYLELAQFHNANQLAAWCLH 609

  Fly   619 YLCVNYNLICKFSLKGLKALHQDNQEYLREHRWPPVWYLKDYDYYQRCLNELNKE---LKLKTSR 680
            ::|.:||.||....|.:|:...:||||..:||||||||||:.|:|||...|..||   |....||
Zfish   610 HICTHYNRICANYRKEIKSKSPENQEYFEKHRWPPVWYLKEEDHYQRVKKEREKEDVVLNKHHSR 674

  Fly   681 R 681
            |
Zfish   675 R 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	127/202 (63%)
		RHO	16..211	CDD:197554	125/199 (63%)
		BTB	<392..446	CDD:295341	17/53 (32%)
		BTB	481..575	CDD:279045	39/93 (42%)
		BTB	485..582	CDD:197585	39/96 (41%)
rhobtb1	XP_003199615.1	RhoBTB	9..203	CDD:133275	127/202 (63%)
		BTB	355..446	CDD:333434	24/93 (26%)
		BTB	477..569	CDD:197585	39/91 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2058
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1354
OMA	1	1.010	-	-		QHG49800
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm24496
orthoMCL	1	0.900	-	-		OOG6_105764
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840