DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoBTB and rhobtb1

DIOPT Version :9

Sequence 1:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_002937150.1	Gene:	rhobtb1 / 100038184	XenbaseID:	XB-GENE-484718	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	717	Identity:	294/717 - (41%)
Similarity:	404/717 - (56%)	Gaps:	101/717 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERS 68
            ||.|:|:.|.:|||:|||.||||||||||||||..::..|||:|||||||||||||:.::|||||
Frog     5 MDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERS 69

  Fly    69 WEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKMMWYPEIRRFCPDVP 133
            .:|||.|:||||||||||||.|||||||||||||:||||||:|.||.:.|.||..||:.|||..|
Frog    70 RDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWAQEIKHFCPRTP 134

  Fly   134 VILVGCKNDLRY-----MYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVAYYETSV 193
            ||||||:.||||     :.|....|:         |...:.|::.|::.|.||||||:.||||||
Frog   135 VILVGCQLDLRYADLEAVNRARRPLA---------RPIKRGDILPPEKGREVAKELGIPYYETSV 190

  Fly   194 FTYFGVNEVFENAIRSALIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTV--MVGNYRQD 256
            |..||:.:||:||||:|||:||..:||.::|||||:|||||||.|||.|||.:.:  .......|
Frog   191 FDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQRPLLQAPFLPPKAPPPVIKIPETPSASMND 255

  Fly   257 IYNMFLSQAYTDLVLVGAGGTKFAVHRFMLAAASSIFQRLLSTELTDMGGRSSSES--------- 312
            ..::..:...:|::.|.....|...|:..||.:||.|..|...|..:  .|.|::.
Frog   256 AGDLLDNPLCSDVLFVLQDQKKIFAHKIYLATSSSKFYDLFLMEHEE--SRHSADRYCKKLNKDL 318

  Fly   313 -----SMVSSTFGE-ATIADFN--------DDT--------EALIRYESRTQRMWEHLKRRSSYQ 355
                 |:.:...|: ||:...|        |||        :..:...|     |
Frog   319 LMRTLSLDTDEDGDVATLKPANACLRTSRSDDTLLTTDLSEDGCVSLSS-----W---------- 368

  Fly   356 ALPLMESKRSNDLYRELHHPVLQSIRLVHVENHRGVNGLQTIVTLSKLISPQALHQCLRFIYTGT 420
                  ||..:.:|:||         .|:..::|...  .|::.:...|........|||:|||.
Frog   369 ------SKGFHSMYQEL---------TVNPVSNRPCP--MTVIRMDSSIQYGPFKTVLRFLYTGQ 416

  Fly   421 IDKDCDNIEEIREAADLLELPQLTQLLSRPQTVMENSSDEPNPHI--------CLRIKESMERHC 477
            :|::...:..:.:.|::||:..|..::..    :.|.....|..|        ..||||     |
Frog   417 LDENEKGLMRVAQIAEILEVFDLRMMVEN----ITNKEAFMNQEITKAFHVRKANRIKE-----C 472

  Fly   478 IGDGCFSDVTFELDDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYL 542
            :....||||||:||||.:.||:.:|:..|:.|.||..|.|.|:.||.:|.|.|:..:...:|.||
Frog   473 LSKATFSDVTFKLDDGSISAHKPLLICSCEWMSAMFGGSFIESASNEVVLPNVSKASMQAILDYL 537

  Fly   543 YTDQIPPISAVKCLNLLELANRLCLPRLLNLVECRVIEDLTLISQNETNETVDH-CLKLLEPVKL 606
            ||.|:...|.:..|.|:.:|||:|||.|:.|.|...:::||..:.:.|:  :|: .|..||..:.
Frog   538 YTKQLAGTSEMDPLELIAVANRMCLPHLVALTEHHAVQELTKAAVSGTD--IDYEVLTYLELAQF 600

  Fly   607 HNAHQLAEWCMSYLCVNYNLICKFSLKGLKALHQDNQEYLREHRWPPVWYLKDYDYYQRCLNELN 671
            |||||||.||:.::|.|||.:|....|.:||...:||||....|||||||||:.|:|||...|..
Frog   601 HNAHQLAAWCLHHVCTNYNSVCAKFRKEIKAKSPENQEYFERQRWPPVWYLKEEDHYQRVKKERE 665

  Fly   672 KE 673
            ||
Frog   666 KE 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	126/202 (62%)
		RHO	16..211	CDD:197554	124/199 (62%)
		BTB	<392..446	CDD:295341	13/53 (25%)
		BTB	481..575	CDD:279045	42/93 (45%)
		BTB	485..582	CDD:197585	41/96 (43%)
rhobtb1	XP_002937150.1	RhoBTB	13..207	CDD:133275	126/202 (62%)
		BTB1_POZ_RHOBTB1	248..454	CDD:349664	45/243 (19%)
		BTB2_POZ_RHOBTB1	459..584	CDD:349667	50/129 (39%)
		BACK_RHOBTB1	587..686	CDD:350605	41/81 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2042
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1331
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246417at33208
OrthoFinder	1	1.000	-	-		FOG0002876
OrthoInspector	1	1.000	-	-		otm48755
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1903
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060