DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ide and AXL1

DIOPT Version :9

Sequence 1:	NP_524182.3	Gene:	Ide / 40248	FlyBaseID:	FBgn0001247	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_015447.1	Gene:	AXL1 / 856240	SGDID:	S000006326	Length:	1208	Species:	Saccharomyces cerevisiae

Alignment Length:	1145	Identity:	246/1145 - (21%)
Similarity:	433/1145 - (37%)	Gaps:	312/1145 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHM-LFLGTEKYPHEN 98
            |.::..:|.||:..|:||||....|:.:|:|..|..:||.::.||||.|||| |..|::|||...
Yeast    22 RTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDPKDIAGLAHLCEHMILSAGSKKYPDPG 86

  Fly    99 GYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDG------ALDRFAQFFIAPLFTPSATEREIN 157
            .:.|.::::.||.||.|....|.::|.:...:.:|      .||.||.||..|||.|....:||.
Yeast    87 LFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLFNPLLISKEIY 151

  Fly   158 AVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDEL-LKFHKQW 221
            |:.||||.|:.|.........|.||.|||.:|:|.:||..:||.||:.|.|.::..| ..|...:
Yeast   152 AIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKKIKLKSSLNTYFENNF 216

  Fly   222 YSANIMCLAVIGKESLDELEGMVLEKFSEIENKNV--------------------KVPGWPRHPY 266
            :..|| .|.:.|.:|::.|..:.|.||.:|:.|:.                    |.....::.|
Yeast   217 FGENI-TLCIRGPQSVNILTKLALSKFGDIKPKSAVKERSISIRTRSFRRSKSLKKRQDSSKNDY 280

  Fly   267 A------------EERY------------------GQKVKIV----PIKDIRSLTISFTTDDLTQ 297
            :            |::|                  ..||.|:    |:.|..:   .||.||:..
Yeast   281 SDLKTFKILNTTWEKKYKNTMCFQQFPECNSIFINSNKVPIMRLLFPVSDKNT---RFTKDDIKI 342

  Fly   298 FYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDI----VVDLTQEGLE 358
            :     .:....|.|.|..||:...|...||.....|    ..:.|...||    .::||..|.|
Yeast   343 Y-----SHLWCELFGDESPGSLSYYLASKGWLTGCFA----FTSEFAIGDIGLILELELTNSGWE 398

  Fly   359 HVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEV- 422
            ::..|..||      |.:..|..::.:     .:....|.:::...:||:....|.:..|:||.
Yeast   399 NIKRITTIV------LNRLLPSFYVMN-----IDYLITFLKEQNLIDLVSFLYQSSEDLPMEECS 452

  Fly   423 LIAPYLSNEWR----PDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTV 483
            .::..|.::..    |::.||.       ||.|.|...:.|            ||..|   |..:
Yeast   453 KLSGILQDDLECLTPPNIFKGF-------KSLIEIDDPNIE------------KYENT---KANI 495

  Fly   484 QSW-----------------ENCEL--------------------------------NENLKLAL 499
            |.|                 :|..|                                ..|:.||.
Yeast   496 QWWTGQAIKFQNFLKSFMNHDNMRLLLLGNIKSGNIFDKMKNKSDICTDFFYEFEYYTANVHLAS 560

  Fly   500 PNSF---------IPT-NFDISDVPADAPK----------------------------HPTIILD 526
            .|.|         .|| |..:.|..:|..|                            .|.::.:
Yeast   561 DNKFHSNSSYEFNFPTGNLFLPDCVSDPLKLQQLFLECSLKSKFATLRPQIYSEPTRTKPQLVSE 625

  Fly   527 TPILRVW-HKQDNQF-NKPKACMTFDM------SNPIAYLDPLNCNLNHMMVM--LLKDQLNEYL 581
            .....:| .|:|..| :..|:.::|::      .:|.|.:        |:.|:  .|....:.:|
Yeast   626 NQNYEMWILKEDPNFASDNKSVVSFEVLGLGIKPSPEATI--------HLEVLAQALFIITSSFL 682

  Fly   582 YDAELASLKLSVMGKSCG---IDFTIRGFSDKQVVLLEKLLDHLFDFSID---------EKRFDI 634
            |.|........:...|.|   :.|||.||.:....:::..:|.|...:.|         .|...:
Yeast   683 YPALRIGYTYEIASSSKGNVTLRFTISGFPEGVFTIVKTFVDTLKLIATDPTFLSKDTLRKARIL 747

  Fly   635 LKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTE 699
            ::.:|    ||..::...:.:...|.::|.:..|...:.::|:||...        |.|::.
Yeast   748 VRNKY----KNASSDNCVKLASVGLLIVLEKYIWTLEDRINALELTEL--------ESFEKF--- 797

  Fly   700 CFIFGNVTK------QQATDIAGRVN--------TRLEATNASKLPILARQMLKKREYKLL--AG 748
            ||:|....|      |.:.:.|..:|        ..|:.:|....|.:  ::......|.|  ..
Yeast   798 CFLFWRNPKHLVLFMQGSLEYADAINRYLNNNFTQHLKISNEGSKPTI--RLYPPPSTKDLDQGT 860

  Fly   749 DSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVL-SEPCYDCLRTKEQLGYIVFSGVR 812
            ::::....::...::....::|...:.|..|:.:..:::.| |......||.|:|:||||..|:|
Yeast   861 NAFISYNGHQDDPNNSIVYFIQTAQRDDIKNLTLTFLTEYLFSLTLVPDLRNKKQIGYIVLGGLR 925

  Fly   813 KVNGANGIRIIVQSAKHPSYVEDRIENF---------------------LQTYLQVIEDMPLDEF 856
            .:....||.|.|.|......:|.||..:                     |:.:|.:::.....:|
Yeast   926 VLTDTVGIHITVMSGSSGHNLETRINEYLSYLQLQVLNRFTEFDFRRILLEPFLNLLKQNSTKQF 990

  Fly   857 E------------------RHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILR 903
            |                  .....|..|::.:.:.:..:.::  |.:..|..|   |..:::.|:
Yeast   991 EGSAGPVDLLNEIVANVQNGDNYTLNNKQMRQHRKVRNKIAE--GRLNFQEDH---EMIDISFLQ 1050

  Fly   904 KISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATS 943
            |::...::.:|:..|:....:|..||:.|.|...::...|
Yeast  1051 KLTLKKYLAFFESKISIYSAQRSKLSIMITSPMAEKEIAS 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ide	NP_524182.3	Ptr	25..952	CDD:223956	246/1145 (21%)
		Peptidase_M16	47..185	CDD:279066	55/144 (38%)
		Peptidase_M16_C	211..386	CDD:282978	47/233 (20%)
		Peptidase_M16_M	395..676	CDD:292805	67/394 (17%)
		Peptidase_M16_C	680..863	CDD:282978	41/238 (17%)
AXL1	NP_015447.1	Ptr	1..1111	CDD:223956	246/1145 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770