DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ide and Ide

DIOPT Version :9

Sequence 1:	NP_524182.3	Gene:	Ide / 40248	FlyBaseID:	FBgn0001247	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_037291.1	Gene:	Ide / 25700	RGDID:	2861	Length:	1019	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	455/972 - (46%)
Similarity:	654/972 - (67%)	Gaps:	20/972 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFL 89
            ::|.||.:|.|:||||:|.||:||||||||.||.|:|||.|.:|.:|||.|:|||:|||||||||
  Rat    52 DHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFL 116

  Fly    90 GTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATER 154
            ||:|||.||.|:.:||:..|||||.|....|.|:|.|:.:.|:||||||||||:.|||..|..:|
  Rat   117 GTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDR 181

  Fly   155 EINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHK 219
            |:|||:||||||:.:|.||:.|:.:....|.|.:||||:|||.||...|..:.||||:||||||.
  Rat   182 EVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHS 246

  Fly   220 QWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIR 284
            .:||:|:|.:.|:|:||||:|..:|::.|||:|||||.:|.:|.||:.||...|..|||||||||
  Rat   247 TYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIR 311

  Fly   285 SLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIV 349
            :|.::|...||.|:|||.|.:||.|||||||.||:||||:..||.|.|:.|.:....||.||.|.
  Rat   312 NLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIIN 376

  Fly   350 VDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSM 414
            ||||:|||.||:||:..:|||::.||.|||::|:|.||..||.:.||||:||:|....:.....:
  Rat   377 VDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKL 441

  Fly   415 QIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVA 479
            ..:||..||.|.||..|:|||||..:||:|.|...|:.|||:|||...|..|.:|.|:|....:.
  Rat   442 HYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIP 506

  Fly   480 KDTVQSWENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPK 544
            :|.:|.|:|.:||...||...|.||||||:|..:..||..:|.:|.||.:.::|.|||::|..||
  Rat   507 EDVIQKWQNADLNGKFKLPTKNEFIPTNFEILALEKDATPYPALIKDTAMSKLWFKQDDKFFLPK 571

  Fly   545 ACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSD 609
            ||:.|:..:|.||:|||:||:.::.:.||||.||||.|.||||.|...:.....|:..:::|::|
  Rat   572 ACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYND 636

  Fly   610 KQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELL 674
            ||.:||:|:.:.:..|.||:|||:|:||.|:|||.||:||||:||::|||.||:||.||...||.
  Rat   637 KQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701

  Fly   675 DAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRV-NTRLEATNASKLPILARQML 738
            :|::.||..|:..|..:...|||.|..:.||:|||.|..:...| :|.:|  :|...|:|..|::
  Rat   702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIE--HAHTKPLLPSQLV 764

  Fly   739 KKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQL 803
            :.||.:|.....:::::.||.|.:...::|.|...|:...|:.:.|..|::||||::.|||||||
  Rat   765 RYREVQLPDRGWFVYQRRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829

  Fly   804 GYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKL 868
            |||||||.|:.||..|:|.|:||.|.|.|:|.|:|.||.|..:.||||..:.|::|.:|||:::|
  Rat   830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRL 894

  Fly   869 EKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIV 933
            :|||.:..:.::::|||..|.|:::|:..|||.|:.:||.|.:.::|:.:|.|...|..:|||::
  Rat   895 DKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVL 959

  Fly   934 SQQTD------------ENATSEAEPVEITNMERHKPISDIVTFKSCKELYPIALPFLDIKA 983
            :::.|            :...|||.|     :.:.:.|.::..||....|:|:..|.::..|
  Rat   960 AREMDSCPVVGEFPSQNDINLSEAPP-----LPQPEVIHNMTEFKRGLPLFPLVKPHINFMA 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ide	NP_524182.3	Ptr	25..952	CDD:223956	448/939 (48%)
		Peptidase_M16	47..185	CDD:279066	82/137 (60%)
		Peptidase_M16_C	211..386	CDD:282978	98/174 (56%)
		Peptidase_M16_M	395..676	CDD:292805	130/280 (46%)
		Peptidase_M16_C	680..863	CDD:282978	74/183 (40%)
Ide	NP_037291.1	Ptr	54..958	CDD:223956	441/904 (49%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P14735	359..363		1/3 (33%)
		SlyX motif. /evidence=ECO:0000250\|UniProtKB:Q9JHR7	853..858		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338297
Domainoid	1	1.000	276	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3645
Inparanoid	1	1.050	923	1.000	Inparanoid score	I335
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	1	1.000	-	-		oto97822
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	1	1.100	-	-	LDO	PTHR43690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1417
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770