DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ide and mug138

DIOPT Version :9

Sequence 1:	NP_524182.3	Gene:	Ide / 40248	FlyBaseID:	FBgn0001247	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_593966.1	Gene:	mug138 / 2542436	PomBaseID:	SPACUNK4.12c	Length:	969	Species:	Schizosaccharomyces pombe

Alignment Length:	966	Identity:	343/966 - (35%)
Similarity:	530/966 - (54%)	Gaps:	40/966 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTEKYPHE 97
            |.|:||.::|||.|:|||:.||.||.::||:.|.:|..|:|..|.||||||||:||:||:|||.|
pombe    20 DDREYRLIKLENDLEVLLVRDPETDNASAAIDVHIGSQSNPRELLGLAHFCEHLLFMGTKKYPDE 84

  Fly    98 NGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREINAVNSE 162
            |.|..||....|.|||.|....|.|:|.|:.|.|.|||||||||||.|||.....:|||.||:||
pombe    85 NEYRKYLESHNGISNAYTASNNTNYYFEVSHDALYGALDRFAQFFIDPLFLEECKDREIRAVDSE 149

  Fly   163 HEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIM 227
            |.|||.||.||..::...|:.|...:|||.:||..||.::||...:|||.|||||:.::||||||
pombe   150 HCKNLQSDSWRFWRLYSVLSNPKSVFSKFNTGNIETLGDVPKELGLDVRQELLKFYDKYYSANIM 214

  Fly   228 CLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTT 292
            .|.:||:|.||.|:....|.||.|:||.|.:|.:|..||.:....:...:.|:|::|.|.|.|..
pombe   215 KLVIIGREPLDVLQDWAAELFSPIKNKAVPIPKFPDPPYTDNEVRKICYVKPVKNLRRLDIVFPI 279

  Fly   293 DDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQN-TQNGFGFFDIVV---DLT 353
            ......||..|..|:.||:||||:||.|:.|:.||....|:|.:.: |::.    ||:|   .||
pombe   280 PGQYHKYKCRPAEYVCHLLGHEGEGSYLAYLKSLGLATSLIAFNVSITEDA----DIIVVSTFLT 340

  Fly   354 QEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSS--MQI 416
            :|||.....::||:|:|:.:|.:....|::|:|...::|.:|:.::| .|.....|.|:|  .:.
pombe   341 EEGLTDYQRVIKILFEYIRLLDQTNAHKFLFEETRIMSEAQFKTRQK-TPAYQYAHVVASKLQRE 404

  Fly   417 FPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKD 481
            :|.::||....:..|:.|..|:.:::.|.|:....::.:.|.|...|..|.:|...||:..:...
pombe   405 YPRDKVLYYSSVLTEFDPKGIQEVVESLRPNNFFAILAAHSIEKGLDNKEKFYGIDYGLEDLDSQ 469

  Fly   482 TVQSWENCELNENLKLALPNSFIPTNFDISDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPKA 545
            .:.|..:.:.:..|.|.|.|.|||.:.::...|.... |.|.::.:...:|:|||:|:.|..|||
pombe   470 FIDSLLHIKTSSELYLPLANEFIPWSLEVEKQPVTTKLKVPNLVRNDKFVRLWHKKDDTFWVPKA 534

  Fly   546 CMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDK 610
            .:..:..:|||...|.......:...|::|.|.||.|.|.||.|..|:...:.||...|.||:||
pombe   535 NVFINFISPIARRSPKVSVSTTLYTRLIEDALGEYSYPASLAGLSFSLSPSTRGIILCISGFTDK 599

  Fly   611 QVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLD 675
            ..|||||::..:.|..:..:||:|||....:.||::.|.:.|..|.:.|..|...::|:|.||.:
pombe   600 LHVLLEKVVAMMRDLKVHPQRFEILKNRLEQELKDYDALEAYHRSNHVLTWLSEPHSWSNAELRE 664

  Fly   676 AMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKL----PILARQ 736
            |::.|....:.:|..:..::...|..:.||.|::.|.::         ..:|.||    |:.|.|
pombe   665 AIKDVQVGDMSDFISDLLKQNFLESLVHGNYTEEDAKNL---------IESAQKLIDPKPVFASQ 720

  Fly   737 MLKKREYKLLAGDSYLFEK--ENEFHKSSCAQLYLQCGAQTD-HTNIMVNLVSQVLSEPCYDCLR 798
            :.:||...:..|.:|:::.  .|:..|:|.....||.....| .:..:..|..|::.||.:..||
pombe   721 LSRKRAIIVPEGGNYIYKTVVPNKEEKNSAIMYNLQISQLDDERSGALTRLARQIMKEPTFSILR 785

  Fly   799 TKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEAL 863
            ||||||||||:.||:|.....:.|.|||.:..:|:|.||...|..:.....:|..::|.:||.:|
pombe   786 TKEQLGYIVFTLVRQVTPFINLNIFVQSERSSTYLESRIRALLDQFKSEFLEMSDEDFSKHKSSL 850

  Fly   864 AVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVL 928
            ....|||...:.::.|.::..|....|.|.|.|.:..|:..|:|.:|..:|...|..:||..:.:
pombe   851 INFMLEKHTNLKEESSMYWLRICDGFYDFTRLEKQAEIVSTITKDEFYSFFINNIHYEGENTKKI 915

  Fly   929 SVHIVSQQTDENATSEAEPVEITN---MERHKPISDIVTFKSCKELYPIALPFLDI 981
            |||:|||:.::      |..||.|   :|......:.:|..  |..:|:. ||.:|
pombe   916 SVHVVSQRCED------EVYEIPNVTIIENGNMFKESMTLS--KAAFPLK-PFDEI 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ide	NP_524182.3	Ptr	25..952	CDD:223956	335/932 (36%)
		Peptidase_M16	47..185	CDD:279066	75/137 (55%)
		Peptidase_M16_C	211..386	CDD:282978	70/178 (39%)
		Peptidase_M16_M	395..676	CDD:292805	85/283 (30%)
		Peptidase_M16_C	680..863	CDD:282978	55/189 (29%)
mug138	NP_593966.1	Ptr	1..951	CDD:223956	338/952 (36%)
		Peptidase_M16	35..172	CDD:279066	75/136 (55%)
		Peptidase_M16_C	198..375	CDD:282978	71/180 (39%)
		Peptidase_M16_M	382..665	CDD:292805	85/283 (30%)
		Peptidase_M16_C	668..850	CDD:282978	55/190 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1098
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3645
Inparanoid	1	1.050	561	1.000	Inparanoid score	I185
OMA	1	1.010	-	-		QHG63000
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	1	1.000	-	-		oto101640
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	1	1.100	-	-	LDO	PTHR43690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R767
SonicParanoid	1	1.000	-	-		X1417
TreeFam	1	0.960	-	-
	14	13.860