DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ide and C02G6.2

DIOPT Version :9

Sequence 1:	NP_524182.3	Gene:	Ide / 40248	FlyBaseID:	FBgn0001247	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_504531.2	Gene:	C02G6.2 / 182128	WormBaseID:	WBGene00015360	Length:	816	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	326/804 - (40%)
Similarity:	475/804 - (59%)	Gaps:	26/804 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHML 87
            |.|:|.|..||.|:.|||:|.|||:|||:|||.||.||.:|:|:.||:.||..||||||||||||
Worm    12 RYNSIVKGPQDERECRGLELTNGLRVLLVSDPTTDKSAVSLAVKAGHLMDPWELPGLAHFCEHML 76

  Fly    88 FLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSAT 152
            ||||.|||.||.:|.:||.:.||.||.|.|..|.|||.|.||:|.||||||.|||:.|.||.|||
Worm    77 FLGTSKYPLENEFTKFLSDNAGSYNACTEPDHTYYHFDVKPDQLYGALDRFVQFFLCPQFTKSAT 141

  Fly   153 EREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKF 217
            |||:.||:|||..||.||.|||.||:|.|::|.|...||.:|||.||.|..:.|.|:.||.||:|
Worm   142 EREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRKFCTGNKKTLLEDARKKGIEPRDALLEF 206

  Fly   218 HKQWYSANIMCLAVIGKESLDELEGMV--LEKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPI 280
            :|:|||:|||...:|||||||.||..:  || |..|:||..:...|....|..::..:|:.:|||
Worm   207 YKKWYSSNIMTCCIIGKESLDVLESYLRTLE-FDAIQNKKAESKVWAEFQYGPDQLAKKIDVVPI 270

  Fly   281 KDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGF 345
            ||.:.::|.|...||...|.|.|.:|:.|||||:|.|||.|||:||||.:.|....:....|||:
Worm   271 KDKKLVSIIFPFPDLNNEYLSQPGHYIAHLIGHKGPGSISSELKRLGWASSLKPESKTIAAGFGY 335

  Fly   346 FDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHA 410
            |::.:||:.|||||||:|::::|.|:.||:..||::||.:|..:|:.:.||||::|.........
Worm   336 FNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPQQWIHEELAELSAIEFRFKDREPLTKNAIKV 400

  Fly   411 VSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSF-EPDCDLAEPYYKTKYG 474
            ..::|..|.|.:|.:.||..::.|:.||.||..|.||...:.:||:.| |.:.:..||.|.|:..
Worm   401 ARNLQYIPFEHILSSRYLLTKYNPERIKELLSTLTPSNMLVRVVSKKFKEQEGNTNEPVYGTEMK 465

  Fly   475 ITRVAKDTVQSWENCELNENLKLALP--NSFIPTNFDISDVPADAPK--HPTIILDTPILRVWHK 535
            :|.::.:.::.:||.....:..|.||  |.:|.|.||  ..|.::.|  ||.:|.|....|||.|
Worm   466 VTDISPEKMKKYENALKTSHHALHLPEKNEYIVTKFD--QKPRESVKNEHPRLISDDGWSRVWFK 528

  Fly   536 QDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMG----- 595
            ||:::|.||.......:.||...:|:...::.:.:..|.|.|.|..|:|.:|.||..:..
Worm   529 QDDEYNMPKQETKLAFTTPIVAQNPIMSLISSLWLWCLNDTLTEETYNAAIAGLKFQLESGHNGV 593

  Fly   596 -----------KSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAE 649
                       :...|...:.|:.:||.:.::.|...:.:|.||..|||::.|...|||.|....
Worm   594 HEQAGNWLDPERHASITLHVYGYDEKQPLFVKHLTKCMTNFKIDRTRFDVVFESLKRSLTNHAFS 658

  Fly   650 QPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDI 714
            |||..|.|:..||:.|..|:..:||...:..|.:.|..|:||.||..|.|.|:.||.|:::|..:
Worm   659 QPYMLSKYFNELLVVEKVWSKEQLLAVCDSATLEDVQGFSKELFQAFHLELFVHGNSTEKKAIQL 723

  Fly   715 AGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTN 779
            :..:...|::...:...:...:...:||::|..||.|::....:.|.:.|.::..:.|.|..:.|
Worm   724 SNELMDILKSAAPNSRLLYRNEHNPRREFQLNNGDEYIYRHLQKTHDAGCVEVTFKFGVQNTYDN 788

  Fly   780 IMVNLVSQVLSEPCYDCLRTKEQL 803
            .:..|:||::.:|.:..|||||.|
Worm   789 ALAGLISQLIRQPAFSTLRTKESL 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ide	NP_524182.3	Ptr	25..952	CDD:223956	325/802 (41%)
		Peptidase_M16	47..185	CDD:279066	88/137 (64%)
		Peptidase_M16_C	211..386	CDD:282978	82/176 (47%)
		Peptidase_M16_M	395..676	CDD:292805	92/301 (31%)
		Peptidase_M16_C	680..863	CDD:282978	36/124 (29%)
C02G6.2	NP_504531.2	PqqL	31..451	CDD:223685	210/420 (50%)
		Peptidase_M16	36..174	CDD:279066	88/137 (64%)
		Peptidase_M16_C	200..377	CDD:282978	82/177 (46%)
		Peptidase_M16_M	385..685	CDD:292805	92/301 (31%)
		Peptidase_M16_C	688..>812	CDD:282978	35/123 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158331
Domainoid	1	1.000	185	1.000	Domainoid score	I2009
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3645
Inparanoid	1	1.050	744	1.000	Inparanoid score	I297
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	1	1.000	-	-		otm14249
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	1	1.100	-	-	O	PTHR43690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1417
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770