DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ide and F44E7.4

DIOPT Version :9

Sequence 1:	NP_524182.3	Gene:	Ide / 40248	FlyBaseID:	FBgn0001247	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_741543.1	Gene:	F44E7.4 / 178966	WormBaseID:	WBGene00018426	Length:	1067	Species:	Caenorhabditis elegans

Alignment Length:	985	Identity:	396/985 - (40%)
Similarity:	588/985 - (59%)	Gaps:	32/985 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGT 91
            |.|..||.|:||||:|.||::|||:|||.||.|||||.|:|||:.||..||||||||||||||||
Worm    75 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHMLFLGT 139

  Fly    92 EKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREI 156
            .|||.||.|:.:|:...|||||.|....|.|||.|.||:|.||||||.|||::|.||.||||||:
Worm   140 AKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREV 204

  Fly   157 NAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQW 221
            .||:|||..||.:||||..||:|..:||.|.|.|||:|||.||.|..:.|.|:.||.||:|||:|
Worm   205 CAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRDALLQFHKKW 269

  Fly   222 YSANIMCLAVIGKESLDELEGMV--LEKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIR 284
            ||::||...::|||.|:.||..:  || |..||||.|:...|...||..::..:::.:|||||.|
Worm   270 YSSDIMTCCIVGKEPLNVLESYLGTLE-FDAIENKKVERKVWEEFPYGPDQLAKRIDVVPIKDTR 333

  Fly   285 SLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIV 349
            .::|||...||...:.|.|.:|::|||||||.||:||||:||||.:.|.:.......|||.:::.
Worm   334 LVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKRLGWVSSLQSDSHTQAAGFGVYNVT 398

  Fly   350 VDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSM 414
            :||:.|||||||:|::::|.|:.||:..|||:|:.||..:|:.::||||:||||..:..:..:|:
Worm   399 MDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHDELAELSAVKFRFKDKEQPMTMAINVAASL 463

  Fly   415 QIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFE-PDCDLAEPYYKTKYGITRV 478
            |..|.|.:|.:.||..::.|:.||.||..|.|:..::.:|||.|: .:.:..||.|.|:..:|.:
Worm   464 QYIPFEHILSSRYLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDI 528

  Fly   479 AKDTVQSWENCELNENLKLALP--NSFIPTNFDISDVPADAPK--HPTIILDTPILRVWHKQDNQ 539
            :.:|::.:||.....:..|.||  |.:|.||||  ..|.::.|  ||.:|.|....|||.|||::
Worm   529 SPETMKKYENALKTSHHALHLPEKNEYIATNFD--QKPRESVKNEHPRLISDDGWSRVWFKQDDE 591

  Fly   540 FNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTI 604
            :|.||......::.|:...:|....|:.:.:..|.|.|.|..|:|:||.||..:.....|:...:
Worm   592 YNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRV 656

  Fly   605 R----------------GFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQ 653
            .                |:.:||.:..:.|.:.:.:|.||:.|||:|.|...|:|.|....|||.
Worm   657 SNRREAERHASLTLHVYGYDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYL 721

  Fly   654 HSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRV 718
            .:.:|..||:.:..|:..:||...:.||.:.|..||||..|..|.|.|:.||.|:::|..::..:
Worm   722 LTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKEL 786

  Fly   719 NTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVN 783
            ...|::...:..|:...:...:||.:|..||.|::....:.|...|.::..|.|.|..:.|.:|.
Worm   787 MDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGVQNTYDNAVVG 851

  Fly   784 LVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVI 848
            |:.|::.||.::.|||.|.|||||::|.|...|...:.:|||..|...:|.:|||.||::..:.|
Worm   852 LIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEI 916

  Fly   849 EDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDY 913
            .:||.:||:.....:..:..|||||:..:|.:|:.||..:.|:|.|.|.|||:|:.|.|.|.::.
Worm   917 AEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLEL 981

  Fly   914 FKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPI---A 975
            |.|.|.||..|||.|:|.:..:..|:.|.:   .:...|.|..|...:::.....::..|:   .
Worm   982 FDKKIRKDAAERRKLAVFVHGKNEDQEAVN---TIIKKNAESGKKEKEVLYSDQLRQFLPLYGRP 1043

  Fly   976 LPFLDIKAKG 985
            :..:|:|..|
Worm  1044 IAAIDLKPIG 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ide	NP_524182.3	Ptr	25..952	CDD:223956	389/947 (41%)
		Peptidase_M16	47..185	CDD:279066	89/137 (65%)
		Peptidase_M16_C	211..386	CDD:282978	82/176 (47%)
		Peptidase_M16_M	395..676	CDD:292805	96/301 (32%)
		Peptidase_M16_C	680..863	CDD:282978	61/182 (34%)
F44E7.4	NP_741543.1	Ptr	75..1039	CDD:223956	392/969 (40%)
		Peptidase_M16	95..233	CDD:279066	89/137 (65%)
		Peptidase_M16_C	259..436	CDD:282978	83/177 (47%)
		Peptidase_M16_M	444..744	CDD:292805	96/301 (32%)
		Peptidase_M16_C	747..925	CDD:282978	60/177 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158328
Domainoid	1	1.000	185	1.000	Domainoid score	I2009
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3645
Inparanoid	1	1.050	744	1.000	Inparanoid score	I297
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	1	1.000	-	-		otm14249
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	1	1.100	-	-	LDO	PTHR43690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R767
SonicParanoid	1	1.000	-	-		X1417
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940