DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ide and nrdc

DIOPT Version :9

Sequence 1:	NP_524182.3	Gene:	Ide / 40248	FlyBaseID:	FBgn0001247	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_031756812.1	Gene:	nrdc / 100489182	XenbaseID:	XB-GENE-970569	Length:	1060	Species:	Xenopus tropicalis

Alignment Length:	1074	Identity:	342/1074 - (31%)
Similarity:	524/1074 - (48%)	Gaps:	133/1074 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQKSATRKPDSMEPILRLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNT--------------- 56
            |.:..|...|.||.    .:|.||..|.:.||.:||:|||:|||:.|...
Frog    22 SDEDETSSIDGMED----PDIVKSPNDPKKYRYIQLDNGLRVLLVCDLTAGEIISEYSEDEIEED 82

  Fly    57 -------------------------------------DVSAAALSVQVGHMSDPTNLPGLAHFCE 84
                                                 .:|||||.|.:|..|||..|.|:|||.|
Frog    83 DEQGQEQEQEQEDECASDSQASESSGVDSGNKQGCEEKLSAAALCVGIGSFSDPEELLGMAHFLE 147

  Fly    85 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTP 149
            ||:|:|:||:|.|||:..:|.:.|||:||:|....|.:.|.|........|||:||||..||...
Frog   148 HMVFMGSEKFPDENGFEVFLKKYGGSTNASTDAERTIFQFDVQRKHFKQGLDRWAQFFTVPLLIR 212

  Fly   150 SATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDEL 214
            .|.|||:.||:||.:...|:|..|.:.:...||||.|..:||..||..||...||.||||....|
Frog   213 DAVEREVEAVDSEFQIGRPNDTNRRQMLFASLAKPGHPMAKFSWGNAQTLKNDPKEKNIDPHSRL 277

  Fly   215 LKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPR--HPYAEERYGQKVKI 277
            .||:::.||||.|.|||..||:|..||..|.|.||.|.|..:..|.:..  .|:....:....::
Frog   278 RKFYERQYSANYMTLAVQSKETLATLEAWVKEIFSNIPNNGLPKPDYSNLTEPFNTPDFNLLYRV 342

  Fly   278 VPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAG------H 336
            ||||...:||||:......|:|:..|..|.:.||||||||||||.||:..|...|..|      .
Frog   343 VPIKKDHTLTISWAMPPQQQYYRVKPLRYFSWLIGHEGKGSILSLLRKKFWAVSLYGGSSPLGAE 407

  Fly   337 QNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKE 401
            ||:.  ...|.|.:.||..|.||..:::.|||||::|::..||::.||.|..::....|||:|:.
Frog   408 QNST--CTVFTINITLTDAGYEHFYEVLHIVFQYVKMMQVLGPQERIFREIQQVEANGFRFQEQT 470

  Fly   402 QPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAE 466
            :....|......||::...::|....|..|::|::|...|....|.|:.::::|.:.|..|||.|
Frog   471 ESIKNVEDICEHMQLYAKADILTGEELLFEYKPEIITNALKYFTPLKANLMLLSPNNEGKCDLVE 535

  Fly   467 PYYKTKYGITRVAKDTVQSWE-----NCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILD 526
            .|:.|:|.    .:|....|:     :..|...|.|...|.||.::|.:........::|..:||
Frog   536 KYFGTQYS----KEDIDPKWKALWATDFPLIPELHLPEENKFIASDFTLKTSDCPNTEYPVKVLD 596

  Fly   527 TPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKL 591
            |.:..:|:|:||:|..|||.:.|.:.:|.....|.|..|..:.:.:|...|.|..|:|:||.|:.
Frog   597 TELGSLWYKKDNKFKIPKAYVRFHLISPEIQKSPENLVLFDIFINILTHTLAESAYEADLAQLEY 661

  Fly   592 SVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSI 656
            .|.....|:...::||:.|..:|.|.::|||.||:.....|:::.|:    ||          .|
Frog   662 KVEAGEHGLIIGVKGFNHKLPLLFELIIDHLADFTASTDEFEMITEQ----LK----------KI 712

  Fly   657 YY------------LALLLTENA-WANMELLDAM-ELVTYDRVLNFAKEFFQRLHTECFIFGNVT 707
            |:            :.|::.|:. |:.|:..:.| :.||..|:|:|.|.|..||:.|..:.||.|
Frog   713 YFNQLIKQTKLGPDIRLIILEHGRWSMMQKYETMLKGVTLKRMLSFVKAFKSRLYAEGLVQGNFT 777

  Fly   708 KQQATDIAGRVNTRLEATN-ASKLPILARQMLKKREYKL--LAGDSYLFEKE--NEFHKSSCAQL 767
            .:::.:....|..:|:.:: .|::|:         |:::  |....:|.:.:  |:...:|...:
Frog   778 CKESVEFLNYVVKKLKFSHLESRIPV---------EFQVVELPSAHHLCKVKALNKEDANSQVTV 833

  Fly   768 YLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIV--QSAKHP 830
            |.|.||:......|:.|:...:.||.:|.||||:.|||.|:...|..:|..|..|.|  |:.|:.
Frog   834 YYQSGARNLREYTMMELLVLHMEEPSFDFLRTKQTLGYQVYPTCRNTSGILGFSITVESQATKYN 898

  Fly   831 S-YVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFER 894
            | :|:.:||.||..:...|.::..:||:...:||..||..:...:.::..:.:.|:..|.|.|||
Frog   899 SEFVDQKIEEFLVLFADKIAELTDEEFKIQVKALIKKKECEDTNLGEEVDRNWNEVVTQQYLFER 963

  Fly   895 EEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPI 959
            ...|::.|:..:|.|.:.:||   |..|.:|:|||||.|       ...|.||...|.....:|.
Frog   964 LTREISALKTFAKEDMISWFK---AHRGSDRKVLSVHAV-------GFGEKEPDAATCYPAGQPD 1018

  Fly   960 SD---IVTFKSCKELYPIALPFLDIKAKGARSKL 990
            |.   .::|.....|...|:...||.|..|..||
Frog  1019 SSSSLCLSFLPATPLMASAVLITDIPAFTAPLKL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ide	NP_524182.3	Ptr	25..952	CDD:223956	325/1013 (32%)
		Peptidase_M16	47..185	CDD:279066	63/189 (33%)
		Peptidase_M16_C	211..386	CDD:282978	72/182 (40%)
		Peptidase_M16_M	395..676	CDD:292805	80/298 (27%)
		Peptidase_M16_C	680..863	CDD:282978	55/190 (29%)
nrdc	XP_031756812.1	Ptr	37..983	CDD:223956	311/974 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R767
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960