DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment in and INTU

DIOPT Version :9

Sequence 1:	NP_788548.1	Gene:	in / 40246	FlyBaseID:	FBgn0001259	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_056508.2	Gene:	INTU / 27152	HGNCID:	29239	Length:	942	Species:	Homo sapiens

Alignment Length:	1002	Identity:	252/1002 - (25%)
Similarity:	402/1002 - (40%)	Gaps:	211/1002 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RKSPASLPSEAFS-------------SSNSSLSNSYSDGSDL-ANWEEYVSTDGSLFYMEYVRCE 52
            |.|...||.:..|             |.:.|.|::.||..|| ..|.:.|..:|.|||:|....|
Human    10 RPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQKNGELFYLELSEDE 74

  Fly    53 KTGVSAE----RRVEFMRRSLRLG---KKSSRRQP-----------------HSNNQNQSQNQNQ 93
            :..:..|    ..|.|....:.:.   |:..:.:|                 ..|.:|.:.|
Human    75 EESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQFTKILRRKRLLPKRCNKKNSNDN--- 136

  Fly    94 SHGP-SRLDSQTEPQ-----EFRFSQFKTAAPDPKKLDLVITAADRFRFGRRSTAVESILG---- 148
              || |.|..|:..:     :.|:....... :|||| .||.|.::.:.      :|.::|
Human   137 --GPVSILKHQSNQKTGVIVQQRYKDVNVYV-NPKKL-TVIKAKEQLKL------LEVLVGIIHQ 191

  Fly   149 ----FRVLPFPDQPECLMVDGFVHDVSALQHG-IKRGDWFRSLNGIEVYASNVDELLKQFVEPTQ 208
                :|........|.|:|.|.:...||::.| :..||...::|.::|...|::.:|.....|.|
Human   192 TKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ 256

  Fly   209 VCLGFQSCGAASAVSPTDPGYNRNVREEQVCKVENFPMFTEKFEQMLITEGNFGIPGSSVDIRMP 273
            |.|.|::            .|:.. ||....:.:.....|....::|..|...||..|.::....
Human   257 VKLTFEN------------AYDVK-RETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQSGLNTPHI 308

  Fly   274 FAMLLLPPECYQHEQQQDSLYYFPEIPDNFLFKA-RGSFLTLHAVLSEL-HTQPLSSRLLVDQVQ 336
            ...|.|..:....:::|:.||::|....:...|: ||.||||..:|..: .||..||.||::..|
Human   309 IMYLTLQLDSETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLLNGKQ 373

  Fly   337 YHVNYRQLNGFLVLFAYAGGLCCAAECSL-----RSDELIGYIRFSLPGLVLESFNQEREPGNSS 396
            .||.|.:.:..|:|....     |.|..|     ..:.:|..::| :.|.:..:|.|..   |..
Human   374 IHVAYWKESDKLLLIGLP-----AEEVPLPRLRNMIENVIQTLKF-MYGSLDSAFCQIE---NVP 429

  Fly   397 RLKLFLRHFCEIQRTRLVARCHGH-------------IRFEELLGQSRSLPLPKEAQLRIFDALS 448
            ||..|...|  .||....|:.|..             :..:.|.| .|.|.||.|.::.:..|||
Human   430 RLDHFFNLF--FQRALQPAKLHSSASPSAQQYDASSAVLLDNLPG-VRWLTLPLEIKMELDMALS 491

  Fly   449 EMEAMDYRNWNDEPLTTHREFFIYGSALYYDGFLVASLLPPEVRVSVEGFLRCRGIFELLGAAPG 513
            ::||.|:...:::.....|.:.|.||:|:|.|:|:.|.||.:..:.:..:  ||. :.||..|..
Human   492 DLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAVY--CRH-YCLLPLAAK 553

  Fly   514 IKVREMYVWEEI---------------VLPSATGRYFLTICTKNHLSLAVILKIFDAPDMAPDAV 563
            .::.::.:|.|:               |.|...|||||.:....|..|.|:|   :|...|..|:
Human   554 QRIGQLIIWREVFPQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYMLCVLL---EAGGCASKAI 615

  Fly   564 --VGPSLFYIEEIQETLDHLVQCGIES-----LAMF---------WSVSNKRPEVLDATASE--S 610
              .||...|:::::.||..|  .|::|     ||..         |.::..|.:....|.|.  |
Human   616 GSPGPDCVYVDQVKTTLHQL--DGVDSRIDERLASSPVPCLSCADWFLTGSREKTDSLTTSPILS 678

  Fly   611 RDQ-----EKEPNNRLESFLKQKLTVLSPSVEEEAQLCSSLGGSSIHSLTPSEDESCRRRLTPIH 670
            |.|     ...|..|...|....|....||..     |||  |.|.:.....||:......||..
Human   679 RLQGTSKVATSPTCRRTLFGDYSLKTRKPSPS-----CSS--GGSDNGCEGGEDDGFSPHTTPDA 736

  Fly   671 GTAEDSDSGSDW------------ENFAVQHPLHYGLNLGAESHSQSQMTESMWKEINNVVPVKI 723
            ...:....|||.            :...:.:|.|.| ||      :..:.|   ||:.....||:
Human   737 VRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLG-NL------KKDLPE---KELEIYNTVKL 791

  Fly   724 SAGWKNSVLHYVYIDIANGSLFAPFTDSSENSNYLSEIRQACHIIHAVLQKSKH---------YR 779
            ::|.:|::.|||.::...|....|         .|.|:.|....||..|.|:.|         ::
Human   792 TSGPENTLFHYVALETVQGIFITP---------TLEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQ 847

  Fly   780 RHLSESSRAQTNSNGHSSHTVSL-----VKEHGMILEVSTQPKSDGQSQSSTSSRFVVVGRLFQS 839
            :.|.|..:...||..||....|:     |||||::.|.|....:| |.::.....:.||||||..
Human   848 QTLVEEKKKGLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTD-QKKAPPVMAYWVVGRLFLH 911

  Fly   840 P-AKEVYVCHRSDVPQNIVEMAFRLSF 865
            | .:|:|||....|.:..:|:||:|.|
Human   912 PKPQELYVCFHDSVTEIAIEIAFKLFF 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
in	NP_788548.1	None
INTU	NP_056508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		11/41 (27%)
		PDZ	199..262	CDD:238080	17/62 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..754		14/56 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147908
Domainoid	1	1.000	159	1.000	Domainoid score	I4082
eggNOG	1	0.900	-	-		E1_28I9D
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41059
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4257
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49554
OrthoDB	1	1.010	-	-		D384173at33208
OrthoFinder	1	1.000	-	-		FOG0006836
OrthoInspector	1	1.000	-	-		oto89330
orthoMCL	1	0.900	-	-		OOG6_106896
Panther	1	1.100	-	-	LDO	PTHR21082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4610
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800