DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and RLP47

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001190722.1	Gene:	RLP47 / 827015	AraportID:	AT4G13810	Length:	706	Species:	Arabidopsis thaliana

Alignment Length:	699	Identity:	136/699 - (19%)
Similarity:	238/699 - (34%)	Gaps:	264/699 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 CLLDLIKDEVIWWQFPNGTLRDSTKKYAH--------------------------KLYLDLSH-- 108
            ||.|. ||.:  |.|.|.....|...||.                          :|.|..||
plant    35 CLPDQ-KDSL--WGFKNEFNVPSPHSYAMTEKWRNNTDCCSWDGVSCDPKTGVVVELDLQYSHLN 96

  Fly   109 GNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPD 173
            |.|:.:|.|||                                  .:.|:.|.|..|:.:.::||
plant    97 GPLRSNSSLFR----------------------------------LQHLQKLVLGSNHLSGILPD 127

  Fly   174 AEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKV 238
            :     ..|..||          ::|:|.|        |.|:....:::|     ..:|...:.:
plant   128 S-----IGNLKRL----------KVLVLVN--------CNLFGKIPSSLG-----NLSYLTHLDL 164

  Fly   239 LKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTIS- 302
            ..:.|...|..|..       .:.||.::.:...|:.::.              :.||::..|:
plant   165 SYNDFTSEGPDSMG-------NLNRLTDMLLKLSSVTWID--------------LGDNQLKGINL 208

  Fly   303 --HDTFYYVQGVQYLDL------SFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIY 359
              ..|......::||.|      .|..||  ..|..|..|:::.:.|.| ::.:.::. ||||.|
plant   209 KISSTVSLPSPIEYLGLLSCNISEFPKFL--RNQTSLEYLDISANQIEG-QVPEWLWS-LPELRY 269

  Fly   360 LDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEG------LDLSGNPYLSY 418
            :::||     ||...|....|                       |::|      ||:|.
plant   270 VNISH-----NSFNGFEGPAD-----------------------VIQGGRELLVLDISS------ 300

  Fly   419 NIIDDAFDGI-ANTLKYLYFERSNIKDLEWSKS---LKNLQVLGLAGNNINALTPAMFQSLESLE 479
            ||..|.|..: ..::.|| |..:|....|..|:   |.||::|.|:.||.:...|..|::|.
plant   301 NIFQDPFPLLPVVSMNYL-FSSNNRFSGEIPKTICELDNLRILVLSNNNFSGSIPRCFENLH--- 361

  Fly   480 ILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTIN-MLSNEMLKDFERLDYLSLGDNDFICDCHLR 543
                                  |.||:||:|.:: :...|.:.  ..|....:|.|.|..:....
plant   362 ----------------------LYVLHLRNNNLSGIFPEEAIS--HHLQSFDVGHNLFSGELPKS 402

  Fly   544 AVVEVAAANNKDADCS-YRLLNYSQNAVGE------EVISLAESLII-DRKLWQSRYIPWLQRSY 600
            .:           :|| ...||...|.:.:      |::...:.|:: ..:.:...:.|....|:
plant   403 LI-----------NCSDIEFLNVEDNRINDTFPSWLELLPNLQILVLRSNEFYGPIFSPGDSLSF 456

  Fly   601 SNIREFNRANHIIKLRFSS---EDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNT 662
            |.:|.|:    |.:.||:.   .||.|.....:.   :.|:||      :::.|
plant   457 SRLRIFD----ISENRFTGVLPSDYFVGWSVMSS---VVDIDG------RIIQY----------- 497

  Fly   663 DQLQVDELNCQIRSMSDLAEELHHVTNTVI--AVMGSLVGACILGFIIY 709
                         :::.:..:.:|.:..:|  .:...|||:   ||.||
plant   498 -------------TVTGIDRDFYHKSVALINKGLKMELVGS---GFTIY 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/27 (26%)
		LRR_8	262..322	CDD:290566	11/68 (16%)
		leucine-rich repeat	264..287	CDD:275380	2/22 (9%)
		leucine-rich repeat	288..311	CDD:275380	4/25 (16%)
		leucine-rich repeat	312..356	CDD:275380	12/49 (24%)
		LRR_8	<344..387	CDD:290566	11/42 (26%)
		leucine-rich repeat	357..381	CDD:275380	7/23 (30%)
		leucine-rich repeat	382..397	CDD:275380	0/14 (0%)
		leucine-rich repeat	405..430	CDD:275380	8/31 (26%)
		LRR_8	431..488	CDD:290566	16/59 (27%)
		leucine-rich repeat	432..453	CDD:275380	7/23 (30%)
		LRR_RI	<449..536	CDD:238064	21/90 (23%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	10/59 (17%)
		leucine-rich repeat	478..501	CDD:275380	0/22 (0%)
		leucine-rich repeat	502..525	CDD:275380	7/23 (30%)
		TIR	751..891	CDD:214587
RLP47	NP_001190722.1	LRR_RI	263..>443	CDD:238064	54/253 (21%)
		leucine-rich repeat	267..292	CDD:275380	10/52 (19%)
		leucine-rich repeat	293..338	CDD:275380	14/51 (27%)
		LRR_8	338..395	CDD:290566	19/83 (23%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
		leucine-rich repeat	385..408	CDD:275380	5/33 (15%)
		leucine-rich repeat	409..432	CDD:275380	4/22 (18%)
		leucine-rich repeat	459..529	CDD:275380	19/109 (17%)
		leucine-rich repeat	513..553	CDD:275380	8/21 (38%)
		leucine-rich repeat	554..577	CDD:275380
		LRR_8	556..612	CDD:290566
		leucine-rich repeat	578..599	CDD:275380
		LRRNT_2	36..79	CDD:285463	10/45 (22%)
		leucine-rich repeat	87..110	CDD:275380	10/56 (18%)
		LRR_8	110..169	CDD:290566	16/86 (19%)
		leucine-rich repeat	111..134	CDD:275380	7/27 (26%)
		leucine-rich repeat	135..158	CDD:275380	7/45 (16%)
		LRR_RI	<150..>301	CDD:238064	39/214 (18%)
		leucine-rich repeat	159..182	CDD:275380	3/29 (10%)
		leucine-rich repeat	183..219	CDD:275380	6/49 (12%)
		leucine-rich repeat	220..242	CDD:275380	7/23 (30%)
		LRR_8	221..277	CDD:290566	19/64 (30%)
		leucine-rich repeat	243..266	CDD:275380	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010