DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and RLP40

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_566757.2	Gene:	RLP40 / 822091	AraportID:	AT3G24982	Length:	915	Species:	Arabidopsis thaliana

Alignment Length:	800	Identity:	167/800 - (20%)
Similarity:	299/800 - (37%)	Gaps:	218/800 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 GNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPD 173
            |.||.:|.||:...| |.:.:        ..|..|::...:.:.|..:|::|||..:.|...:|.
plant   117 GTLKPNSSLFQFHHL-RSLLL--------PHNNFTSSSISSKFGMLNNLEVLSLSSSGFLAQVPF 172

  Fly   174 AEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRN------- 231
            :     |.|.|.|.|                         |..:||...| |::..||
plant   173 S-----FSNLSMLSA-------------------------LVLSNNDLTG-SLSFARNLRKLRVL 206

  Fly   232 ---YTNFIKVLKDR---FDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRR 290
               |.:|..:|...   |:.|.....::.:..|           ::.|:.|    .|.|::.|..
plant   207 DVSYNHFSGILNPNSSLFELHHIIYLNLRYNNF-----------TSSSLPY----EFGNLNKLEV 256

  Fly   291 LFMSDNKIM-----TISHDTFYYVQGVQ-YLDLSFTNFLTYSYQLQLPTLEMALSLIYGL----K 345
            |.:|.|...     |||:.|    |..: ||.|   |..|.|..|.....::::..::|.    .
plant   257 LDVSSNSFFGQVPPTISNLT----QLTELYLPL---NHFTGSLPLVQNLTKLSILHLFGNHFSGT 314

  Fly   346 IQQNVFKYLPELIYLDLSHSKM---------TRNSAVAFAHLGD---------------KLKFLS 386
            |..::|. :|.|.||.|..:.:         :.:|.:...|||:               .||.|.
plant   315 IPSSLFT-MPFLSYLSLKGNNLNGSIEVPNSSSSSRLESLHLGENHFEGKILEPISKLINLKELD 378

  Fly   387 LCY--TAIPMVSSTIF---KNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL- 445
            |.:  |:.| :..::|   |:.:|  |||||:.....::..|::  |.:||:.|..|..:|.|.
plant   379 LSFLNTSYP-IDLSLFSSLKSLLL--LDLSGDWISKASLTLDSY--IPSTLEVLRLEHCDISDFP 438

  Fly   446 EWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSA-FHNNSALRVLNLRS 509
            ...|:|.||:.:.|:.|.|:...|....||..|..:.::.|.:..:..|: ...||::::|:|.:
plant   439 NVFKTLHNLEYIALSNNRISGKFPEWLWSLPRLSSVFITDNLLTGFEGSSEVLVNSSVQILSLDT 503

  Fly   510 NTI--------------NMLSNEMLKDF-------ERLDYLSLGDNDF---ICDCHLRAVVEVAA 550
            |::              :.:.|....|.       ..||.|.|..|:|   |..|....:.....
plant   504 NSLEGALPHLPLSINYFSAIDNRFGGDIPLSICNRSSLDVLDLSYNNFTGPIPPCLSNLLYLKLR 568

  Fly   551 ANNKDA--------DCSYRLLNYSQNAV-GE-----------EVISLAESLIIDRKLWQSRYIPW 595
            .||.:.        |...|.|:...|.: |:           :.:|:..:.|.|...:..:.:|.
plant   569 KNNLEGSIPDKYYEDTPLRSLDVGYNRLTGKLPRSLINCSALQFLSVDHNGIKDTFPFSLKALPK 633

  Fly   596 LQ--------------------RSYSNIREFNRANHIIKLRFSSEDYMVA-KCSAAQPYHLGDLD 639
            ||                    ..:..:|....|.:.:...|.|.|:.|. |.|:    |  .::
plant   634 LQVLLLSSNKFYGPLSPPNEGPLGFPELRILEIAGNKLTGSFLSSDFFVNWKASS----H--TMN 692

  Fly   640 GDLTL-----KFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLV 699
            .||.|     |....:|..:.|    .|..|:...|:.:.|::...:..:....|.:...:...:
plant   693 EDLGLYMVYGKVIFGNYHLTYY----ETIDLRYKGLSMEQRNVLTSSATIDFSGNRLEGEIPESI 753

  Fly   700 GACILGFIIYLK------RWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDI-FISY 757
            |  :|..:|.|.      ..||...:::||....|..:|.:       :|...|:.:..: |::|
plant   754 G--LLKALIALNLSNNAFTGHIPLSFANLKKMESLDLSSNQ-------LSGTIPNGLRTLSFLAY 809

  Fly   758 CQNDRTWVLNELLPNVEETG 777
            .......::.|:....:.||
plant   810 VNVSHNQLIGEIPQGTQITG 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/27 (30%)
		LRR_8	262..322	CDD:290566	16/65 (25%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..311	CDD:275380	8/27 (30%)
		leucine-rich repeat	312..356	CDD:275380	10/48 (21%)
		LRR_8	<344..387	CDD:290566	14/70 (20%)
		leucine-rich repeat	357..381	CDD:275380	8/47 (17%)
		leucine-rich repeat	382..397	CDD:275380	6/16 (38%)
		leucine-rich repeat	405..430	CDD:275380	8/24 (33%)
		LRR_8	431..488	CDD:290566	18/57 (32%)
		leucine-rich repeat	432..453	CDD:275380	7/21 (33%)
		LRR_RI	<449..536	CDD:238064	25/108 (23%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..536	CDD:290566	15/80 (19%)
		leucine-rich repeat	478..501	CDD:275380	4/23 (17%)
		leucine-rich repeat	502..525	CDD:275380	5/43 (12%)
		TIR	751..891	CDD:214587	4/27 (15%)
RLP40	NP_566757.2	LRR_RI	97..>263	CDD:238064	42/200 (21%)
		LRR_8	130..190	CDD:290566	19/98 (19%)
		leucine-rich repeat	131..155	CDD:275380	5/32 (16%)
		leucine-rich repeat	156..179	CDD:275380	8/27 (30%)
		leucine-rich repeat	180..202	CDD:275380	9/47 (19%)
		LRR_8	201..264	CDD:290566	14/77 (18%)
		leucine-rich repeat	203..228	CDD:275380	4/24 (17%)
		leucine-rich repeat	229..253	CDD:275380	5/38 (13%)
		leucine-rich repeat	254..277	CDD:275380	8/26 (31%)
		leucine-rich repeat	278..300	CDD:275380	7/24 (29%)
		leucine-rich repeat	301..324	CDD:275380	3/23 (13%)
		leucine-rich repeat	325..349	CDD:275380	4/23 (17%)
		leucine-rich repeat	350..371	CDD:275380	3/20 (15%)
		LRR_8	422..481	CDD:290566	18/58 (31%)
		leucine-rich repeat	424..446	CDD:275380	7/21 (33%)
		leucine-rich repeat	447..468	CDD:275380	5/20 (25%)
		leucine-rich repeat	471..495	CDD:275380	4/23 (17%)
		leucine-rich repeat	517..540	CDD:275380	2/22 (9%)
		leucine-rich repeat	541..585	CDD:275380	11/43 (26%)
		LRR_8	560..620	CDD:290566	8/59 (14%)
		leucine-rich repeat	563..583	CDD:275380	2/19 (11%)
		leucine-rich repeat	586..609	CDD:275380	4/22 (18%)
		leucine-rich repeat	610..633	CDD:275380	3/22 (14%)
		leucine-rich repeat	634..660	CDD:275380	2/25 (8%)
		leucine-rich repeat	735..758	CDD:275380	3/24 (13%)
		leucine-rich repeat	759..782	CDD:275380	5/22 (23%)
		LRR_8	762..817	CDD:290566	11/61 (18%)
		leucine-rich repeat	783..806	CDD:275380	4/29 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000