DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr9

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_112455.2	Gene:	Tlr9 / 81897	MGIID:	1932389	Length:	1032	Species:	Mus musculus

Alignment Length:	927	Identity:	199/927 - (21%)
Similarity:	336/927 - (36%)	Gaps:	280/927 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KSLMLKYESDDGNSCLLDLI-KDEVI------WWQ-FPNGTLRDSTKKYAHKLYLDLSHGNLKDD 114
            |||.|..|:....|.|..|: ||..:      |:| ..|.::.|.::.:   ||..::|.|...:
Mouse   271 KSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLSVLDLSENF---LYESITHTNAFQN 332

  Fly   115 SDLFREAKLS----RKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAE 175
            ....|:..||    :||:..|..:         |:.|:.|.|::|    |::.|
Mouse   333 LTRLRKLNLSFNYRKKVSFARLHL---------ASSFKNLVSLQE----LNMNG----------- 373

  Fly   176 DFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLK 240
            .|.|.:|:..|.....:|   :|..||         ..:.|.|...:  ||........|:.:..
Mouse   374 IFFRLLNKYTLRWLADLP---KLHTLH---------LQMNFINQAQL--SIFGTFRALRFVDLSD 424

  Fly   241 DRF-------------------------DQHGSSSQSIAWATFPKMPRL----VELDISNCSIEY 276
            :|.                         |.|.:...:.|...|  |.|.    ..:|:|..::..
Mouse   425 NRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNF--MDRCKNFKFTMDLSRNNLVT 487

  Fly   277 VSKEAFRNVSNLRRLFMSDNKI-MTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSL 340
            :..|.|.|:|.|:.|.:|.|.| ..::...|..:..:|.||||......|.::
Mouse   488 IKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWK------------ 540

  Fly   341 IYGLKIQQNVFKYLPELIYLDLSHS------KMTRNSAVAFAHLGDKLKFLSLCYTAI-PMVSST 398
                     .|..||:|..||||::      |...::.....|| ..|:.|||.:..| ..|||.
Mouse   541 ---------SFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHL-SMLQSLSLAHNDIHTRVSSH 595

  Fly   399 IFKNTVLEGLDLSGNP----------YLSYNIIDDAFDGIANTLKYLYFERSNIKDLEWSKSLKN 453
            :..|:| ..||.|||.          ||.:      |.|::..||
Mouse   596 LNSNSV-RFLDFSGNGMGRMWDEGGLYLHF------FQGLSGLLK-------------------- 633

  Fly   454 LQVLGLAGNNINALTPAMFQSL-ESLEILDLSSNHVG--NWYRSAFHNNSALRVLNLRSNTINML 515
               |.|:.||::.|.|....:| :||::|.|..|::.  ||...:|..|  |.||:|..|.:..|
Mouse   634 ---LDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPN--LEVLDLAGNQLKAL 693

  Fly   516 SNEMLKDFERLDYLSLGDNDFICDCHLRAVVE---VAAANNKDADCSYRLLNYSQNAVGEEVISL 577
            :|..|.:...|..|.:..|..:      :||.   ..|...|:.:.|:.:|.
Mouse   694 TNGTLPNGTLLQKLDVSSNSIV------SVVPAFFALAVELKEVNLSHNILK------------- 739

  Fly   578 AESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDL 642
                .:||.        |.                                           |.:
Mouse   740 ----TVDRS--------WF-------------------------------------------GPI 749

  Fly   643 TLKFQLLDYEASQYYCFNNTD--------QLQVDEL----NC----QIRSMSDLAEELHHVTNTV 691
            .:...:||..::..:|.....        |.:|..|    .|    |::..|..|::|....:.|
Mouse   750 VMNLTVLDVRSNPLHCACGAAFVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDEV 814

  Fly   692 IA--VMGSLVGACILGFII----YLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAV 750
            ::  ..|..:.|..:|.::    :|..|.:.|.:....:...|.:.|:.|       :|..|
Mouse   815 LSWDCFGLSLLAVAVGMVVPILHHLCGWDVWYCFHLCLAWLPLLARSRRS-------AQTLP--- 869

  Fly   751 YDIFISYCQNDRT------WVLNELLPNVEETGD---VSICLHERDFQIGVTILDNIISCMDRSY 806
            ||.|:.:   |:.      ||.|||...:||...   :.:||.:||:..|.|:.:|:.:.:..|.
Mouse   870 YDAFVVF---DKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSR 931

  Fly   807 SLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTLQYLMDVKTYIKWP 871
            ..:.:::....:|...:....|||.|:.|..|:.::||.|.....|.|...|:..:..::.:.||
Mouse   932 KTLFVLAHTDRVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWP 996

  Fly   872 TAKEDRKLFWKRLKRSL 888
            .....:..||.:|..:|
Mouse   997 QQPNGQGGFWAQLSTAL 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	5/27 (19%)
		LRR_8	262..322	CDD:290566	18/64 (28%)
		leucine-rich repeat	264..287	CDD:275380	5/26 (19%)
		leucine-rich repeat	288..311	CDD:275380	6/23 (26%)
		leucine-rich repeat	312..356	CDD:275380	8/43 (19%)
		LRR_8	<344..387	CDD:290566	13/48 (27%)
		leucine-rich repeat	357..381	CDD:275380	8/29 (28%)
		leucine-rich repeat	382..397	CDD:275380	6/15 (40%)
		leucine-rich repeat	405..430	CDD:275380	9/34 (26%)
		LRR_8	431..488	CDD:290566	14/57 (25%)
		leucine-rich repeat	432..453	CDD:275380	2/20 (10%)
		LRR_RI	<449..536	CDD:238064	27/89 (30%)
		leucine-rich repeat	454..477	CDD:275380	7/23 (30%)
		LRR_8	477..536	CDD:290566	20/60 (33%)
		leucine-rich repeat	478..501	CDD:275380	8/24 (33%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		TIR	751..891	CDD:214587	38/147 (26%)
Tlr9	NP_112455.2	leucine-rich repeat	43..64	CDD:275380
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	47..51
		LRR 1	62..85
		LRR_8	63..135	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	72..77
		LRR 2	87..110
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	95..109
		LRR 3	122..147
		leucine-rich repeat	125..168	CDD:275380
		LRR_8	143..211	CDD:290566
		LRR 4	150..166
		LRR 5	167..190
		leucine-rich repeat	169..200	CDD:275380
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	179..181
		LRR_RI	<194..373	CDD:238064	30/117 (26%)
		LRR 6	198..221
		LRR_8	199..254	CDD:290566
		leucine-rich repeat	201..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		LRR 7	223..242
		LRR 8	243..268
		leucine-rich repeat	246..285	CDD:275380	5/13 (38%)
		LRR 9	283..306		6/22 (27%)
		LRR_8	284..344	CDD:290566	16/62 (26%)
		leucine-rich repeat	286..309	CDD:275380	6/22 (27%)
		LRR 10	308..332		6/26 (23%)
		leucine-rich repeat	310..335	CDD:275380	5/27 (19%)
		LRR 11	333..356		6/22 (27%)
		leucine-rich repeat	336..365	CDD:275380	9/37 (24%)
		LRR 12	363..386		9/37 (24%)
		LRR 13	390..413		8/36 (22%)
		leucine-rich repeat	393..411	CDD:275380	6/28 (21%)
		LRR 14	415..440		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..462		2/31 (6%)
		LRR 15	471..495		4/23 (17%)
		leucine-rich repeat	477..498	CDD:275380	5/20 (25%)
		LRR_RI	<490..>641	CDD:238064	51/202 (25%)
		LRR_8	497..556	CDD:290566	21/79 (27%)
		LRR 16	497..520		7/22 (32%)
		leucine-rich repeat	499..523	CDD:275380	6/23 (26%)
		LRR 17	521..544		7/43 (16%)
		leucine-rich repeat	524..547	CDD:275380	8/43 (19%)
		LRR 18	546..573		7/26 (27%)
		leucine-rich repeat	548..577	CDD:275380	8/29 (28%)
		LRR 19	575..599		9/24 (38%)
		leucine-rich repeat	578..600	CDD:275380	8/21 (38%)
		leucine-rich repeat	601..630	CDD:275380	10/35 (29%)
		LRR 20	601..623		7/22 (32%)
		LRR_8	<623..690	CDD:290566	25/97 (26%)
		LRR 21	628..651		8/45 (18%)
		leucine-rich repeat	631..679	CDD:275380	17/70 (24%)
		LRR 22	653..676		7/22 (32%)
		LRR 23	677..700		9/24 (38%)
		leucine-rich repeat	680..703	CDD:275380	8/22 (36%)
		LRR 24	702..724		5/27 (19%)
		leucine-rich repeat	704..752	CDD:275380	13/121 (11%)
		LRR 25	725..748		7/90 (8%)
		LRR 26	750..773		3/22 (14%)
		leucine-rich repeat	753..774	CDD:275380	3/20 (15%)
		TIR_2	870..>974	CDD:304906	29/106 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920