DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and TLR5

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_003259.2 Gene:TLR5 / 7100 HGNCID:11851 Length:858 Species:Homo sapiens


Alignment Length:889 Identity:189/889 - (21%)
Similarity:324/889 - (36%) Gaps:291/889 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 RECYLYFNNNTNMGQSI-TTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCS 273
            |..:..|.|.|.:.|.: ||.|...:|..:            :::..::||.:.:|..|::.:  
Human    29 RIAFYRFCNLTQVPQVLNTTERLLLSFNYI------------RTVTASSFPFLEQLQLLELGS-- 79

  Fly   274 IEY----VSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTL 334
             :|    :.||||||:.|||.|.:..:||..:..|.|   ||:.:|           ::|:|   
Human    80 -QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAF---QGLFHL-----------FELRL--- 126

  Fly   335 EMALSLIYGLK---IQQNVFKYLPELIYLDLSHS------------KMTRNSAVAFAH------- 377
                 ...||.   ::...|:.|..|..||||.:            |:....::.|:.       
Human   127 -----YFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVC 186

  Fly   378 -------LGDKLKFLSLC----YTAIPM---VSSTIFKNTVLEGLDLSGNPY------------- 415
                   .|..|.|.||.    |:.:.:   .....|:|.|||.||:|||.:             
Human   187 EHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAIS 251

  Fly   416 --------LSYNIIDDAF------DGIANTLKYLYFERSNIKDLEWS------------KSLKNL 454
                    |:::|:...|      |...||...|  .||:::.|:.|            ::||:|
Human   252 KSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGL--ARSSVRHLDLSHGFVFSLNSRVFETLKDL 314

  Fly   455 QVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEM 519
            :||.||.|.||.:....|..|::|::|:||.|.:|..|.|.|:....:..::|:.|.|.::.::.
Human   315 KVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT 379

  Fly   520 LKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNK----------------------DADCSYRL 562
            .|..|:|..|.|.||.......:.::.::..:.||                      :.|..|.|
Human   380 FKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL 444

  Fly   563 LNY----------------------SQNA------VGEEVISLAESLIIDRKLWQSRYIPW---- 595
            |..                      |:|.      :||.::.||         |::. :.|    
Human   445 LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLA---------WETE-LCWDVFE 499

  Fly   596 ----LQRSYSNIREFNRA-----NHIIKLRFSS--EDYMVAKCSAAQPYHLGDLD---------- 639
                ||..|.|....|..     :|:..||..|  .:.:........|.:|..||          
Human   500 GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPN 564

  Fly   640 GDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACIL 704
            .|:.:...:||...:::.|            .|:   :|.....|:| ||..||...:       
Human   565 PDVFVSLSVLDITHNKFIC------------ECE---LSTFINWLNH-TNVTIAGPPA------- 606

  Fly   705 GFIIYLKRWHIHYYYSSLKSAALLSSASKE-------------------------------SVNK 738
                     .|:..|....|...|.|.|.|                               :|.|
Human   607 ---------DIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTK 662

  Fly   739 FTNI-------SQR----------DPSAV-YDIFISYCQNDRTWVLNELLPNVE----ETGDVSI 781
            |...       :||          :|... ||.::.:...|.|||.|.||.:::    :....::
Human   663 FRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNL 727

  Fly   782 CLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFL 846
            |..||||..|...:.||...:..|..::.::|..||...||......||.|........||:|.:
Human   728 CFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVV 792

  Fly   847 EDIPRRK--RPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            ..:.:.:  :.::::..:..:.|::||...:|...|..:|.:.:
Human   793 GSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQI 836

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380
LRR_8 262..322 CDD:290566 20/63 (32%)
leucine-rich repeat 264..287 CDD:275380 9/26 (35%)
leucine-rich repeat 288..311 CDD:275380 7/22 (32%)
leucine-rich repeat 312..356 CDD:275380 7/46 (15%)
LRR_8 <344..387 CDD:290566 13/71 (18%)
leucine-rich repeat 357..381 CDD:275380 8/49 (16%)
leucine-rich repeat 382..397 CDD:275380 5/21 (24%)
leucine-rich repeat 405..430 CDD:275380 11/51 (22%)
LRR_8 431..488 CDD:290566 23/68 (34%)
leucine-rich repeat 432..453 CDD:275380 6/32 (19%)
LRR_RI <449..536 CDD:238064 31/86 (36%)
leucine-rich repeat 454..477 CDD:275380 10/22 (45%)
LRR_8 477..536 CDD:290566 19/58 (33%)
leucine-rich repeat 478..501 CDD:275380 9/22 (41%)
leucine-rich repeat 502..525 CDD:275380 4/22 (18%)
TIR 751..891 CDD:214587 35/144 (24%)
TLR5NP_003259.2 LRR 1. /evidence=ECO:0000269|PubMed:22173220 45..68 5/34 (15%)
leucine-rich repeat 48..83 CDD:275378 8/49 (16%)
LRR 2. /evidence=ECO:0000269|PubMed:22173220 71..93 7/24 (29%)
PLN00113 90..>581 CDD:331614 116/524 (22%)
LRR 3. /evidence=ECO:0000269|PubMed:22173220 95..117 8/24 (33%)
leucine-rich repeat 97..120 CDD:275380 9/25 (36%)
LRR 4. /evidence=ECO:0000269|PubMed:22173220 120..143 6/41 (15%)
leucine-rich repeat 121..146 CDD:275380 7/43 (16%)
LRR 5. /evidence=ECO:0000269|PubMed:22173220 146..166 5/19 (26%)
leucine-rich repeat 147..171 CDD:275380 6/23 (26%)
LRR 6. /evidence=ECO:0000269|PubMed:22173220 171..192 1/20 (5%)
leucine-rich repeat 172..205 CDD:275380 6/32 (19%)
LRR 7. /evidence=ECO:0000269|PubMed:22173220 197..211 5/13 (38%)
LRR 8. /evidence=ECO:0000269|PubMed:22173220 214..229 3/14 (21%)