DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-9 and TLR4

DIOPT Version :10

Sequence 1:NP_649214.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:938 Identity:208/938 - (22%)
Similarity:331/938 - (35%) Gaps:326/938 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 LLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSH-------GNLKDDSDLFREAKLSRKVTIW 130
            :|||.:.|:       .|:.|..       |..|||       ||......|...:.||....:.
Human    82 VLDLSRCEI-------QTIEDGA-------YQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLV 132

  Fly   131 RTEVFSAAFNTLTAAPFRTL------YSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLE-A 188
            ..|...|:.........:||      :::.:|.||              .|.|:...|...|: :
Human   133 AVETNLASLENFPIGHLKTLKELNVAHNLIQSFKL--------------PEYFSNLTNLEHLDLS 183

  Fly   189 SNSVPH-HC-ELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIK------------VL 239
            ||.:.. :| :|.:||....|           |.::..|:    |..|||:            .|
Human   184 SNKIQSIYCTDLRVLHQMPLL-----------NLSLDLSL----NPMNFIQPGAFKEIRLHKLTL 233

  Fly   240 KDRFDQHGSSSQSIAWATFPKMPRLVELDISN-CSIEYVSKEAFRNVSNLR----RL-----FMS 294
            ::.||........|......::.|||..:..| .::|...|.|...:.||.    ||     ::.
Human   234 RNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLD 298

  Fly   295 D-----NKIMTISH-----------DTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEM--ALSLI 341
            |     |.:..:|.           ..|.|..|.|:|:|....|      .|.|||::  ...|.
Human   299 DIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKF------GQFPTLKLKSLKRLT 357

  Fly   342 YGLKIQQNVFKY--LPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTV 404
            :......|.|..  ||.|.:||||     ||.          |.|...|       |.:.|..|.
Human   358 FTSNKGGNAFSEVDLPSLEFLDLS-----RNG----------LSFKGCC-------SQSDFGTTS 400

  Fly   405 LEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL-EWS-------------------- 448
            |:.||||.|..::   :...|.|: ..|::|.|:.||:|.: |:|                    
Human   401 LKYLDLSFNGVIT---MSSNFLGL-EQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRV 461

  Fly   449 ------KSLKNLQVLGLAGNNINA-LTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLN 506
                  ..|.:|:||.:|||:... ..|.:|..|.:|..||||...:.....:||::.|:|:|||
Human   462 AFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLN 526

  Fly   507 LRSN---TINMLSNEMLKDFERLDY----------------------LSLGDNDFICDCHLRAVV 546
            :..|   :::....:.|...:.|||                      |:|..|||.|.|.     
Human   527 MSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCE----- 586

  Fly   547 EVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWL--QRSYSNIREFNRA 609
                                                      ...::.|:  ||           
Human   587 ------------------------------------------HQSFLQWIKDQR----------- 598

  Fly   610 NHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQ--LQVDELN- 671
                                                 ||| .|..:..|...:|:  :.|..|| 
Human   599 -------------------------------------QLL-VEVERMECATPSDKQGMPVLSLNI 625

  Fly   672 -CQIRSMSDLAEELHHVTNTVIAV-MGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKE 734
             ||             :..|:|.| :.|::...::..::|      .:|:..:..|..:.....|
Human   626 TCQ-------------MNKTIIGVSVLSVLVVSVVAVLVY------KFYFHLMLLAGCIKYGRGE 671

  Fly   735 SVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNI 798
            :              :||.|:.|...|..||.|||:.|:|| .....:|||.|||..||.|..||
Human   672 N--------------IYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANI 722

  Fly   799 I-SCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRR--KRPKTLQY 860
            | ....:|..:::::|..|:.|.||.||..:||...|..|:..:|.:.|:.:.:.  ::...|..
Human   723 IHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYR 787

  Fly   861 LMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            |:...||::|..:...|.:||:||:::|
Human   788 LLSRNTYLEWEDSVLGRHIFWRRLRKAL 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_649214.1 LRR 198..537 CDD:443914 104/433 (24%)
leucine-rich repeat 264..287 CDD:275380 6/23 (26%)
leucine-rich repeat 288..311 CDD:275380 8/47 (17%)
leucine-rich repeat 312..356 CDD:275380 12/47 (26%)
leucine-rich repeat 357..381 CDD:275380 7/23 (30%)
leucine-rich repeat 382..397 CDD:275380 3/14 (21%)
leucine-rich repeat 405..430 CDD:275380 8/24 (33%)
leucine-rich repeat 432..453 CDD:275380 9/47 (19%)
leucine-rich repeat 454..477 CDD:275380 9/23 (39%)
leucine-rich repeat 478..501 CDD:275380 7/22 (32%)
leucine-rich repeat 502..525 CDD:275380 6/25 (24%)
TIR 751..891 CDD:214587 50/142 (35%)
TLR4NP_612564.1 LRR 1 55..76
leucine-rich repeat 56..79 CDD:275378
LRR_8 57..114 CDD:404697 12/45 (27%)
PPP1R42 76..>190 CDD:455733 28/135 (21%)
LRR 2 79..100 7/31 (23%)
leucine-rich repeat 80..103 CDD:275378 8/34 (24%)
LRR 3 103..124 4/20 (20%)
leucine-rich repeat 104..127 CDD:275378 4/22 (18%)
LRR 4 127..148 2/20 (10%)
leucine-rich repeat 128..176 CDD:275378 9/61 (15%)
leucine-rich repeat 130..151 CDD:275380 2/20 (10%)
LRR 5 151..172 6/34 (18%)
LRR 6 176..199 6/22 (27%)
leucine-rich repeat 177..190 CDD:275378 3/12 (25%)
leucine-rich repeat 195..224 CDD:275380 10/43 (23%)
LRR 7 205..225 6/23 (26%)
LRR 8 227..247 3/19 (16%)
LRR 290..>581 CDD:443914 79/322 (25%)
LRR 9 331..351 9/25 (36%)
LRR 10 352..373 3/20 (15%)
leucine-rich repeat 353..374 CDD:275380 4/20 (20%)
LRR 11 374..394 11/41 (27%)
LRR 12 400..422 8/25 (32%)
leucine-rich repeat 401..423 CDD:275380 8/25 (32%)
LRR 13 423..444 8/20 (40%)
leucine-rich repeat 424..448 CDD:275380 8/23 (35%)
LRR 14 448..456 0/7 (0%)
leucine-rich repeat 449..472 CDD:275380 1/22 (5%)
LRR 15 472..495 8/22 (36%)
leucine-rich repeat 473..497 CDD:275380 9/23 (39%)
LRR 16 497..518 7/20 (35%)
leucine-rich repeat 498..521 CDD:275380 7/22 (32%)
LRR 17 521..542 5/20 (25%)
LRR 18 545..565 3/19 (16%)
leucine-rich repeat 546..570 CDD:275380 3/23 (13%)
LRRCT 579..625 CDD:214507 16/141 (11%)
TIR 674..815 CDD:214587 49/140 (35%)
Blue background indicates that the domain is not in the aligned region.

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