| Sequence 1: | NP_001246846.1 | Gene: | Toll-9 / 40245 | FlyBaseID: | FBgn0036978 | Length: | 900 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_612564.1 | Gene: | TLR4 / 7099 | HGNCID: | 11850 | Length: | 839 | Species: | Homo sapiens |
| Alignment Length: | 938 | Identity: | 208/938 - (22%) |
|---|---|---|---|
| Similarity: | 331/938 - (35%) | Gaps: | 326/938 - (34%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 73 LLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSH-------GNLKDDSDLFREAKLSRKVTIW 130
Fly 131 RTEVFSAAFNTLTAAPFRTL------YSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLE-A 188
Fly 189 SNSVPH-HC-ELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIK------------VL 239
Fly 240 KDRFDQHGSSSQSIAWATFPKMPRLVELDISN-CSIEYVSKEAFRNVSNLR----RL-----FMS 294
Fly 295 D-----NKIMTISH-----------DTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEM--ALSLI 341
Fly 342 YGLKIQQNVFKY--LPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTV 404
Fly 405 LEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL-EWS-------------------- 448
Fly 449 ------KSLKNLQVLGLAGNNINA-LTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLN 506
Fly 507 LRSN---TINMLSNEMLKDFERLDY----------------------LSLGDNDFICDCHLRAVV 546
Fly 547 EVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWL--QRSYSNIREFNRA 609
Fly 610 NHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQ--LQVDELN- 671
Fly 672 -CQIRSMSDLAEELHHVTNTVIAV-MGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKE 734
Fly 735 SVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNI 798
Fly 799 I-SCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRR--KRPKTLQY 860
Fly 861 LMDVKTYIKWPTAKEDRKLFWKRLKRSL 888 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Toll-9 | NP_001246846.1 | leucine-rich repeat | 157..185 | CDD:275380 | 5/27 (19%) |
| LRR_8 | 262..322 | CDD:290566 | 20/85 (24%) | ||
| leucine-rich repeat | 264..287 | CDD:275380 | 6/23 (26%) | ||
| leucine-rich repeat | 288..311 | CDD:275380 | 8/47 (17%) | ||
| leucine-rich repeat | 312..356 | CDD:275380 | 12/47 (26%) | ||
| LRR_8 | <344..387 | CDD:290566 | 13/44 (30%) | ||
| leucine-rich repeat | 357..381 | CDD:275380 | 7/23 (30%) | ||
| leucine-rich repeat | 382..397 | CDD:275380 | 3/14 (21%) | ||
| leucine-rich repeat | 405..430 | CDD:275380 | 8/24 (33%) | ||
| LRR_8 | 431..488 | CDD:290566 | 23/84 (27%) | ||
| leucine-rich repeat | 432..453 | CDD:275380 | 9/47 (19%) | ||
| LRR_RI | <449..536 | CDD:238064 | 30/112 (27%) | ||
| leucine-rich repeat | 454..477 | CDD:275380 | 9/23 (39%) | ||
| LRR_8 | 477..536 | CDD:290566 | 20/83 (24%) | ||
| leucine-rich repeat | 478..501 | CDD:275380 | 7/22 (32%) | ||
| leucine-rich repeat | 502..525 | CDD:275380 | 6/25 (24%) | ||
| TIR | 751..891 | CDD:214587 | 50/142 (35%) | ||
| TLR4 | NP_612564.1 | LRR_RI | 55..>195 | CDD:238064 | 29/140 (21%) |
| LRR 1 | 55..76 | ||||
| leucine-rich repeat | 56..79 | CDD:275378 | |||
| LRR_8 | 57..114 | CDD:290566 | 12/45 (27%) | ||
| LRR 2 | 79..100 | 7/31 (23%) | |||
| leucine-rich repeat | 80..103 | CDD:275378 | 8/34 (24%) | ||
| LRR_8 | 102..187 | CDD:290566 | 20/98 (20%) | ||
| LRR 3 | 103..124 | 4/20 (20%) | |||
| leucine-rich repeat | 104..127 | CDD:275378 | 4/22 (18%) | ||
| LRR 4 | 127..148 | 2/20 (10%) | |||
| leucine-rich repeat | 128..176 | CDD:275378 | 9/61 (15%) | ||
| leucine-rich repeat | 130..151 | CDD:275380 | 2/20 (10%) | ||
| LRR 5 | 151..172 | 6/34 (18%) | |||
| LRR_RI | 152..456 | CDD:238064 | 84/364 (23%) | ||
| LRR 6 | 176..199 | 6/22 (27%) | |||
| leucine-rich repeat | 177..190 | CDD:275378 | 3/12 (25%) | ||
| leucine-rich repeat | 195..224 | CDD:275380 | 10/43 (23%) | ||
| LRR 7 | 205..225 | 6/23 (26%) | |||
| LRR 8 | 227..247 | 3/19 (16%) | |||
| LRR 9 | 331..351 | 9/25 (36%) | |||
| LRR 10 | 352..373 | 3/20 (15%) | |||
| leucine-rich repeat | 353..374 | CDD:275380 | 4/20 (20%) | ||
| LRR_RI | <372..581 | CDD:238064 | 61/234 (26%) | ||
| LRR 11 | 374..394 | 11/41 (27%) | |||
| LRR_8 | 399..458 | CDD:290566 | 17/62 (27%) | ||
| LRR 12 | 400..422 | 8/25 (32%) | |||
| leucine-rich repeat | 401..423 | CDD:275380 | 8/25 (32%) | ||
| LRR 13 | 423..444 | 8/20 (40%) | |||
| leucine-rich repeat | 424..448 | CDD:275380 | 8/23 (35%) | ||
| LRR_8 | 447..508 | CDD:290566 | 15/60 (25%) | ||
| LRR 14 | 448..456 | 0/7 (0%) | |||
| leucine-rich repeat | 449..472 | CDD:275380 | 1/22 (5%) | ||
| LRR 15 | 472..495 | 8/22 (36%) | |||
| leucine-rich repeat | 473..497 | CDD:275380 | 9/23 (39%) | ||
| LRR 16 | 497..518 | 7/20 (35%) | |||
| leucine-rich repeat | 498..521 | CDD:275380 | 7/22 (32%) | ||
| LRR_8 | 520..581 | CDD:290566 | 13/60 (22%) | ||
| LRR 17 | 521..542 | 5/20 (25%) | |||
| LRR 18 | 545..565 | 3/19 (16%) | |||
| leucine-rich repeat | 546..570 | CDD:275380 | 3/23 (13%) | ||
| LRRCT | 579..625 | CDD:214507 | 16/141 (11%) | ||
| TIR | 674..815 | CDD:214587 | 49/140 (35%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D147327at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR24365 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 3.020 | |||||