DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and TLR3

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_003256.1	Gene:	TLR3 / 7098	HGNCID:	11849	Length:	904	Species:	Homo sapiens

Alignment Length:	883	Identity:	208/883 - (23%)
Similarity:	336/883 - (38%)	Gaps:	221/883 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 KYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTL-YSMRESLKLL 160
            |..:.:.|||||..|.       ..||..:|.:...:....:.|.:.|.....| .....|||.|
Human   145 KQKNLITLDLSHNGLS-------STKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKL 202

  Fly   161 SLRGNNFAELIPD-----AEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFN--- 217
            .|..|...|..|.     ...|..|:|..:|..|                 |.::.|....|
Human   203 ELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPS-----------------LTEKLCLELANTSI 250

  Fly   218 NNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAF 282
            .|.::..|..:..:.|.|:               .:.|.      .|..||:|..::..|..::|
Human   251 RNLSLSNSQLSTTSNTTFL---------------GLKWT------NLTMLDLSYNNLNVVGNDSF 294

  Fly   283 RNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDL--SFT------------NFLTYSYQLQLPT 333
            ..:..|...|:..|.|..:...:.:.:..|:||:|  |||            :..::.:...|..
Human   295 AWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEH 359

  Fly   334 LEMALSLIYGLKIQQNVFKYLPELIYLDLSHS-----KMTRNSAVAFAHLGDKLKFLSLCYTAIP 393
            |.|..:.|.|:|  .|:|..|..|.||.||:|     .:|..:.|:.||  ..|..|:|....|.
Human   360 LNMEDNDIPGIK--SNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--SPLHILNLTKNKIS 420

  Fly   394 MVSSTIFK-NTVLEGLDLSGNP-------------------YLSYN----IIDDAFDGIANTLKY 434
            .:.|..|. ...||.|||..|.                   |||||    :..::| .:..:|:.
Human   421 KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSF-ALVPSLQR 484

  Fly   435 LYFERSNIKDLEWSKS----LKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSA 495
            |...|..:|:::.|.|    |:||.:|.|:.|||..:...|.:.||.||||||..|::...::
Human   485 LMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWK-- 547

  Fly   496 FHNN-----------SALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVA 549
             |.|           |.|.:|||.||..:.:..|:.||...|..:.||.|:.       ..:..:
Human   548 -HANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNL-------NTLPAS 604

  Fly   550 AANNKDADCSYRLLNYSQNAV--------GEEVISLAESLIIDRKL-----------WQSRYIPW 595
            ..||:   .|.:.||..:|.:        |....:|.|   :|.:.           |   ::.|
Human   605 VFNNQ---VSLKSLNLQKNLITSVEKKVFGPAFRNLTE---LDMRFNPFDCTCESIAW---FVNW 660

  Fly   596 LQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFN 660
            :..:::||.|.            |..|:   |:....||          .|.:..::.|
Human   661 INETHTNIPEL------------SSHYL---CNTPPHYH----------GFPVRLFDTS------ 694

  Fly   661 NTDQLQVDELNCQIRSMSDLAE-ELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKS 724
                           |..|.|. ||..:.||.|     |:....:..:|:.:.|.|.:|:
Human   695 ---------------SCKDSAPFELFFMINTSI-----LLIFIFIVLLIHFEGWRISFYW----- 734

  Fly   725 AALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVSICLHERDFQ 789
                 :.|...|..|..|.::.....|..:|.:...|:.||........:|...:..||.||||:
Human   735 -----NVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFE 794

  Fly   790 IGVTILDNIISCMDRSYSLMLIISSKFLLSHWC-QFEMYLAQHRIFEVSKEHLILVFLEDIPRRK 853
            .||..|:.|::.:.||..::.:|:...|....| :|:::.|..:..|.:.:.:||||||:||..|
Human   795 AGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYK 859

  Fly   854 RPKTL---QYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            ....|   :.:......:.||..||....|..:|:.:|
Human   860 LNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVAL 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	10/32 (31%)
		LRR_8	262..322	CDD:290566	17/73 (23%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	4/22 (18%)
		leucine-rich repeat	312..356	CDD:275380	16/57 (28%)
		LRR_8	<344..387	CDD:290566	16/47 (34%)
		leucine-rich repeat	357..381	CDD:275380	10/28 (36%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	12/47 (26%)
		LRR_8	431..488	CDD:290566	24/60 (40%)
		leucine-rich repeat	432..453	CDD:275380	7/24 (29%)
		LRR_RI	<449..536	CDD:238064	35/101 (35%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	23/69 (33%)
		leucine-rich repeat	478..501	CDD:275380	9/33 (27%)
		leucine-rich repeat	502..525	CDD:275380	9/22 (41%)
		TIR	751..891	CDD:214587	41/142 (29%)
TLR3	NP_003256.1	LRRNT	28..50	CDD:396168
		leucine-rich repeat	33..52	CDD:275380
		LRR 1	52..73
		leucine-rich repeat	53..76	CDD:275380
		PLN00113	72..>542	CDD:215061	112/446 (25%)
		LRR 2	76..97
		leucine-rich repeat	77..100	CDD:275380
		LRR 3	100..121
		leucine-rich repeat	101..124	CDD:275380
		LRR 4	124..145		208/883 (24%)
		leucine-rich repeat	125..148	CDD:275380	1/2 (50%)
		LRR 5	148..168		8/26 (31%)
		leucine-rich repeat	149..198	CDD:275380	12/55 (22%)
		LRR 6	172..193		3/20 (15%)
		LRR 7	198..219		8/20 (40%)
		leucine-rich repeat	199..249	CDD:275380	15/66 (23%)
		LRR 8	222..244		7/38 (18%)
		LRR 9	249..270		4/35 (11%)
		leucine-rich repeat	250..275	CDD:275380	5/45 (11%)
		LRR 10	275..296		6/20 (30%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR 11	299..320		4/20 (20%)
		leucine-rich repeat	300..321	CDD:275380	4/20 (20%)
		LRR 12	323..344		7/20 (35%)
		LRR 13	356..377		8/22 (36%)
		leucine-rich repeat	357..380	CDD:275380	9/24 (38%)
		LRR 14	380..400		7/19 (37%)
		leucine-rich repeat	381..406	CDD:275380	8/24 (33%)
		LRR 15	408..429		6/20 (30%)
		leucine-rich repeat	409..432	CDD:275380	6/22 (27%)
		LRR 16	432..454		6/21 (29%)
		leucine-rich repeat	433..457	CDD:275380	6/23 (26%)
		leucine-rich repeat	458..481	CDD:275380	6/23 (26%)
		LRR 17	465..486		4/21 (19%)
		leucine-rich repeat	482..507	CDD:275380	7/24 (29%)
		LRR 18	507..528		8/20 (40%)
		leucine-rich repeat	508..531	CDD:275380	8/22 (36%)
		LRR 19	531..552		9/23 (39%)
		leucine-rich repeat	532..563	CDD:275380	9/33 (27%)
		LRR_8	562..622	CDD:404697	20/69 (29%)
		LRR 20	563..584		7/20 (35%)
		leucine-rich repeat	564..585	CDD:275380	8/20 (40%)
		LRR 21	587..608		4/27 (15%)
		leucine-rich repeat	588..611	CDD:275380	6/32 (19%)
		LRR 22	611..632		4/20 (20%)
		leucine-rich repeat	612..630	CDD:275380	3/17 (18%)
		leucine-rich repeat	637..659	CDD:275380	4/27 (15%)
		LRRCT	645..697	CDD:214507	13/100 (13%)
		Tlr3_TMD	698..730	CDD:407816	10/36 (28%)
		TIR	755..900	CDD:214587	41/143 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920