DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and TLR2

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001305716.1	Gene:	TLR2 / 7097	HGNCID:	11848	Length:	784	Species:	Homo sapiens

Alignment Length:	966	Identity:	212/966 - (21%)
Similarity:	373/966 - (38%)	Gaps:	263/966 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PKYIWDVIVLVCLFLGNVREAYTEFSI---QDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKY 64
            |..:|.|.||..:...:..|:..:.|:   ::|:......:..|.......:.:..||.:..:.|
Human     2 PHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITY 66

  Fly    65 ESD-DGNSCL----LDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREAKLS 124
            .|: |...|:    |.|..:.:      |....||........:||||:..|.:.|
Human    67 ISNSDLQRCVNLQALVLTSNGI------NTIEEDSFSSLGSLEHLDLSYNYLSNLS--------- 116

  Fly   125 RKVTIWRTEVFSAAFNTLTAAPFRT-----LYSMRESLKLLSLRGN--NFAELIPDAEDFA--RF 180
               :.|...:.|..|..|...|::|     |:|....|::|.: ||  .|.::  ..:|||  .|
Human   117 ---SSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV-GNMDTFTKI--QRKDFAGLTF 175

  Fly   181 VNESRLEASN-------------SVPHHCELLLLH------------------NTTDLYDRECYL 214
            :.|..::||:             :|.|    |:||                  ...:|.|.:...
Human   176 LEELEIDASDLQSYEPKSLKSIQNVSH----LILHMKQHILLLEIFVDVTSSVECLELRDTDLDT 236

  Fly   215 YFNNNTNMGQSITTGRNYT-NFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVS 278
            :..:..:.|::.:..:.:| ..:|:..:...|        ......::..|:||:..:|::..|.
Human   237 FHFSELSTGETNSLIKKFTFRNVKITDESLFQ--------VMKLLNQISGLLELEFDDCTLNGVG 293

  Fly   279 KEAFRNVSNLRRLFMSDNKIMTIS----HDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALS 339
            .  ||...|.|  .:...|:.|::    |...:|:    :.|||....||  .:::..|:|.:..
Human   294 N--FRASDNDR--VIDPGKVETLTIRRLHIPRFYL----FYDLSTLYSLT--ERVKRITVENSKV 348

  Fly   340 LIYGLKIQQNVFKYLPELIYLDLSHSKMT----RNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIF 400
            .:....:.|    :|..|.|||||.:.|.    :|||               |..|.|.:.:.|.
Human   349 FLVPCLLSQ----HLKSLEYLDLSENLMVEEYLKNSA---------------CEDAWPSLQTLIL 394

  Fly   401 KNTVLEGLDLSGNPYL------SYNIIDDAFDGIANT------LKYLYFERSNIKDLEWSKSLKN 453
            :...|..|:.:|...|      :.:|..::|..:..|      :|||....:.|..:..... |.
Human   395 RQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIP-KT 458

  Fly   454 LQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNE 518
            |::|.::.||:|..:    .:|..|:.|.:|.|.:.....::.  ...|.||.:..|.|...|.|
Human   459 LEILDVSNNNLNLFS----LNLPQLKELYISRNKLMTLPDASL--LPMLLVLKISRNAITTFSKE 517

  Fly   519 MLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLII 583
            .|..|..|..|..|.|:|||.|                    ..|:::|     |..:||: ::|
Human   518 QLDSFHTLKTLEAGGNNFICSC--------------------EFLSFTQ-----EQQALAK-VLI 556

  Fly   584 DRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQL 648
            |   |.:.|   |..|.|::    |...:..:|.|     |::|
Human   557 D---WPANY---LCDSPSHV----RGQQVQDVRLS-----VSEC--------------------- 585

  Fly   649 LDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYL--- 710
                                                 |.|..|       .|.|...|::.|
Human   586 -------------------------------------HRTALV-------SGMCCALFLLILLTG 606

  Fly   711 ---KRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPN 772
               .|:|..:|...:  .|.|.:..|.......||       .||.|:||.:.|..||.|.::..
Human   607 VLCHRFHGLWYMKMM--WAWLQAKRKPRKAPSRNI-------CYDAFVSYSERDAYWVENLMVQE 662

  Fly   773 VEE-TGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEV 836
            :|. .....:|||:|||..|..|:||||..:::|:..:.::|..|:.|.||::|:..:..|:|:.
Human   663 LENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDE 727

  Fly   837 SKEHLILVFLEDIPRRKRPK---TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
            :.:..||:.||.|.::..|:   .|:.:|:.|||::||..:..|:.||..|:.:::
Human   728 NNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIK 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	10/31 (32%)
		LRR_8	262..322	CDD:290566	16/63 (25%)
		leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..311	CDD:275380	5/26 (19%)
		leucine-rich repeat	312..356	CDD:275380	9/43 (21%)
		LRR_8	<344..387	CDD:290566	12/46 (26%)
		leucine-rich repeat	357..381	CDD:275380	10/27 (37%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	6/30 (20%)
		LRR_8	431..488	CDD:290566	16/62 (26%)
		leucine-rich repeat	432..453	CDD:275380	4/20 (20%)
		LRR_RI	<449..536	CDD:238064	24/86 (28%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	17/58 (29%)
		leucine-rich repeat	478..501	CDD:275380	4/22 (18%)
		leucine-rich repeat	502..525	CDD:275380	9/22 (41%)
		TIR	751..891	CDD:214587	48/143 (34%)
TLR2	NP_001305716.1	PLN00113	<40..>206	CDD:331614	41/190 (22%)
		leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		LRR 1	54..77		6/22 (27%)
		LRR_8	77..135	CDD:316378	15/75 (20%)
		leucine-rich repeat	78..101	CDD:275380	5/28 (18%)
		LRR 2	78..101		5/28 (18%)
		leucine-rich repeat	102..125	CDD:275380	7/34 (21%)
		LRR 3	102..125		7/34 (21%)
		leucine-rich repeat	126..150	CDD:275380	6/23 (26%)
		LRR 4	126..150		6/23 (26%)
		leucine-rich repeat	151..175	CDD:275380	8/26 (31%)
		LRR 5	151..175		8/26 (31%)
		LRR 6	176..199		3/22 (14%)
		leucine-rich repeat	176..196	CDD:275380	3/19 (16%)
		LRR 7	200..223		5/26 (19%)
		LRR 8	224..250		3/25 (12%)
		LRR 9	251..278		3/34 (9%)
		LRR 10	279..308		9/32 (28%)
		LRR 11	309..337		8/33 (24%)
		NEL	<324..>558	CDD:330839	69/294 (23%)
		LRR 12	338..361		4/26 (15%)
		leucine-rich repeat	362..388	CDD:275380	12/40 (30%)
		LRR 13	362..388		12/40 (30%)
		leucine-rich repeat	389..414	CDD:275380	5/24 (21%)
		LRR 14	389..414		5/24 (21%)
		leucine-rich repeat	415..437	CDD:275380	3/21 (14%)
		LRR 15	415..437		3/21 (14%)
		leucine-rich repeat	438..478	CDD:275380	11/44 (25%)
		LRR 16	438..457		4/19 (21%)
		LRR 17	458..478		6/23 (26%)
		leucine-rich repeat	479..500	CDD:275380	4/22 (18%)
		LRR 18	479..500		4/22 (18%)
		leucine-rich repeat	501..524	CDD:275380	9/22 (41%)
		LRR 19	501..524		9/22 (41%)
		LRRCT	533..586	CDD:214507	22/151 (15%)
		TIR	640..784	CDD:214587	48/144 (33%)
		ATG16L1-binding motif	761..778		6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5140
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3640
Isobase	1	0.950	-	0	Normalized mean entropy	S6596
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm41867
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.980