DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and TLR1

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_003254.2	Gene:	TLR1 / 7096	HGNCID:	11847	Length:	786	Species:	Homo sapiens

Alignment Length:	945	Identity:	212/945 - (22%)
Similarity:	361/945 - (38%)	Gaps:	270/945 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TEFSI---QDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQF 86
            :||.:   ::|||..|...:           ::|.:.::...|.|:...|.:|.|.|..::....
Human    25 SEFLVDRSKNGLIHVPKDLS-----------QKTTILNISQNYISELWTSDILSLSKLRILIISH 78

  Fly    87 PNGTLRD-STKKYAHKL-YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRT 149
            ......| |..|:..:| ||||||..|         .|:|...|: ..:....:||...|.|...
Human    79 NRIQYLDISVFKFNQELEYLDLSHNKL---------VKISCHPTV-NLKHLDLSFNAFDALPICK 133

  Fly   150 LYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVP-HHCE----LLLLHNT----- 204
            .:.....||.|.|                   :.:.||.|:.:| .|..    ||:|..|
Human   134 EFGNMSQLKFLGL-------------------STTHLEKSSVLPIAHLNISKVLLVLGETYGEKE 179

  Fly   205 -----TDLYDRECYLYFNNNTN----MGQSITTGRN--YTNFIKVLKDRFDQHGSSSQSIAWATF 258
                 .|......::.|..|..    :..|:.|..|  .:|...||:|....:..|    ..|..
Human   180 DPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLS----ILAKL 240

  Fly   259 PKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYY-------VQGVQYLD 316
            ...|:|..|.::|....:   .:|..:..|            :.|.|.:|       :||    .
Human   241 QTNPKLSNLTLNNIETTW---NSFIRILQL------------VWHTTVWYFSISNVKLQG----Q 286

  Fly   317 LSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDK 381
            |.|.:|......|:..::...:|.::|          .|:....::..:...:|..|:    |.:
Human   287 LDFRDFDYSGTSLKALSIHQVVSDVFG----------FPQSYIYEIFSNMNIKNFTVS----GTR 337

  Fly   382 LKFLSLCYTAIP----------MVSSTIFKN----TVLEGLDLSGNPYLSYNIIDDAFDGIANTL 432
            :..: ||.:.|.          :::.|:|:|    |.||.|.|..|.....:.|.:....: .:|
Human   338 MVHM-LCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQM-KSL 400

  Fly   433 KYLYFERSNIK------DLEWSKSLKNLQVLGLAGNNINALTPAMFQSL-ESLEILDLSSNHVGN 490
            :.|...::::.      |..|:|||.:|.:      :.|.||..:|:.| ..:::|||.||.:.:
Human   401 QQLDISQNSVSYDEKKGDCSWTKSLLSLNM------SSNILTDTIFRCLPPRIKVLDLHSNKIKS 459

  Fly   491 WYRS------------AFH---------NNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDN 534
            ..:.            ||:         :.|:|.||.:..|:::..|.:..:..:::..:..|||
Human   460 IPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDN 524

  Fly   535 DFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRS 599
            .|.|.|.|...|:                |..|  |..||:          :.|...|
Human   525 PFQCTCELGEFVK----------------NIDQ--VSSEVL----------EGWPDSY------- 554

  Fly   600 YSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQ 664
                                      ||...:.|.     |.|     |.|:..|
Human   555 --------------------------KCDYPESYR-----GTL-----LKDFHMS---------- 573

  Fly   665 LQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLK-RWHIHYYYSSLKSAALL 728
                ||:|.|..:          ..|::|.| .::...:.....||. .|::.......::....
Human   574 ----ELSCNITLL----------IVTIVATM-LVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRA 623

  Fly   729 SSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVSICLHERDFQIGVT 793
            .:...|.:.:  |:.       :..||||..:|..||.||||||:|:.| :.||||||:|..|.:
Human   624 RNIPLEELQR--NLQ-------FHAFISYSGHDSFWVKNELLPNLEKEG-MQICLHERNFVPGKS 678

  Fly   794 ILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKT- 857
            |::|||:|:::||..:.::|..|:.|.||.:|:|.|.|.:|......|||:.||.||:...|.:
Human   679 IVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSY 743

  Fly   858 --LQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEV 890
              |:.||..:||::||..|..|.|||..|:.::.:
Human   744 HKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINI 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	4/27 (15%)
		LRR_8	262..322	CDD:290566	13/66 (20%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..311	CDD:275380	4/29 (14%)
		leucine-rich repeat	312..356	CDD:275380	6/43 (14%)
		LRR_8	<344..387	CDD:290566	4/42 (10%)
		leucine-rich repeat	357..381	CDD:275380	3/23 (13%)
		leucine-rich repeat	382..397	CDD:275380	3/24 (13%)
		leucine-rich repeat	405..430	CDD:275380	6/24 (25%)
		LRR_8	431..488	CDD:290566	18/63 (29%)
		leucine-rich repeat	432..453	CDD:275380	7/26 (27%)
		LRR_RI	<449..536	CDD:238064	25/108 (23%)
		leucine-rich repeat	454..477	CDD:275380	6/23 (26%)
		LRR_8	477..536	CDD:290566	16/79 (20%)
		leucine-rich repeat	478..501	CDD:275380	7/43 (16%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	61/143 (43%)
TLR1	NP_003254.2	leucine-rich repeat	47..70	CDD:275378	6/22 (27%)
		LRR 1	54..77		6/22 (27%)
		LRR_8	69..124	CDD:316378	15/64 (23%)
		leucine-rich repeat	71..94	CDD:275378	3/22 (14%)
		LRR 2	78..101		7/22 (32%)
		leucine-rich repeat	95..115	CDD:275378	11/29 (38%)
		LRR 3	102..125		6/32 (19%)
		leucine-rich repeat	116..140	CDD:275378	4/23 (17%)
		LRR 4	126..150		6/42 (14%)
		leucine-rich repeat	141..152	CDD:275378	4/29 (14%)
		LRR 5	151..175		8/23 (35%)
		LRR 6	176..199		2/22 (9%)
		LRR 7	200..223		4/22 (18%)
		LRR 8	224..250		7/29 (24%)
		LRR 9	251..278		6/41 (15%)
		LRR 10	279..308		6/32 (19%)
		LRR 11	309..337		6/41 (15%)
		Interaction with bacterial lipopeptide	313..316		1/12 (8%)
		LRR 12	338..361		3/23 (13%)
		PLN00113	<352..>560	CDD:331614	53/275 (19%)
		leucine-rich repeat	352..373	CDD:275380	3/20 (15%)
		LRR 13	362..388		9/25 (36%)
		leucine-rich repeat	374..399	CDD:275380	6/25 (24%)
		LRR 14	389..414		3/25 (12%)
		leucine-rich repeat	400..424	CDD:275380	4/23 (17%)
		LRR 15	415..437		8/27 (30%)
		leucine-rich repeat	425..446	CDD:275380	7/26 (27%)
		LRR 16	438..457		7/18 (39%)
		leucine-rich repeat	447..469	CDD:275380	5/21 (24%)
		LRR 17	458..478		1/19 (5%)
		leucine-rich repeat	470..492	CDD:275380	3/21 (14%)
		LRR 18	479..500		4/20 (20%)
		leucine-rich repeat	494..515	CDD:275380	4/20 (20%)
		LRR 19	501..524		2/22 (9%)
		LRRCT	553..577	CDD:279765	11/80 (14%)
		TIR	636..779	CDD:214587	61/151 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5140
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3640
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm41867
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.030